Diabetes Mellitus, Type 2 study with SNP Genotypes (Array) data on dbGaP (2,004 participants)

phs000140 — A Whole Genome Association Search for Type 2 Diabetes Genes in African    Americans

<p>Over 2.8 million African Americans have type 2 diabetes mellitus (T2DM).  This represents approximately 13% of the African American   population and a significant proportion of the 21 million Americans living with diabetes. On average, an African American individual   is twice as likely to have T2DM as a European American peer. Our research group has been actively involved in the study of African   American diabetes genetics for over 15 years. We hypothesize that genes contributing to the development of T2DM in African Americans   exist and can be located using modern molecular genetic methods. With the exception of TCF7L2(Transcription factor 7-like 2) evidence   to date suggests variants that contribute T2DM risk in European-derived populations are not significant contributors to African   American T2DM risk. We have performed a SNP-based Whole Genome Association (WGA) analysis on the Affymetrix 6.0 in a   case control population of over 1000 African American T2DM cases and over 1000 non-diabetic controls. The DNAs have been   collected from participants using uniform criteria from North Carolina and neighboring states. Genotype data will   be subjected to extensive genetic analysis with the goal of defining a priority list of SNPs for genotyping in independent   populations for confirmation and further detailed analysis.</p>