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Genome-Wide Association Study of Parkinson Disease

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Demographics (8)

Disease Events (68)

  • Action_or_Postural_Tremor_of_Left_Hand - Participant's score determined by examiner for action tremor in left hand while participant is in "on" or "off" state. (phv00076056.v1.p1)
  • Action_or_Postural_Tremor_of_Right_Hand - Participant's score determined by examiner for action tremor in right hand while participant is in "on" or "off" state. (phv00076055.v1.p1)
  • AFFECTION_STATUS - Affection Status (phv00076090.v1.p1)
  • Anorexia_Nausea_Vomiting - Participant's response to examiner's question of whether or not the participant had anorexia, nausea, or vomiting in the past week. (phv00076083.v1.p1)
  • Arising_from_Chair - Participant's score determined by examiner for attempting to rise from straight-back wood or metal chair with arms folded across chest while participant is in "on" or "off" state. (phv00076070.v1.p1)
  • Body_Bradykinesia_and_Hypokinesia - Participant's score determined by examiner for combining slowness, hesitancy, decreased arm swing, small amplitude, and poverty of movement in general while participant is in "on" or "off" state. (phv00076074.v1.p1)
  • Clinical_Fluctuations_Duration - Participant's response to examiner's question of what portion of the waking day participant is "off" on average in the past week. (phv00076082.v1.p1)
  • Clinical_Fluctuations_Predictable - Participant's response to examiner's question, "Are any "off" periods predictable as to timing after a dose of medication?", in the past week. (phv00076079.v1.p1)
  • Clinical_Fluctuations_Sudden - Participant's response to examiner's question, "Do any of the "off" periods come on suddenly?", in the past week. (phv00076081.v1.p1)
  • Clinical_Fluctuations_Unpredictable - Participant's response to examiner's question, "Are any "off" periods unpredictable as to timing after a dose of medication?", in the past week. (phv00076080.v1.p1)
  • Cutting_Food_and_Handling_Utensils - Participant's response to interview, indicating level of food cutting and utensil handling function during the past week. (phv00076038.v1.p1)
  • Dressing - Participant's response to interview, indicating level of dressing function during the past week. (phv00076039.v1.p1)
  • Dx_by_UKBB_criteria - Was subject diagnosed as having PD according to modified UK-Brain Bank criteria? (Modified only not to exclude based on positive family history.) (phv00076417.v1.p1)
  • Dyskinesia_Disability - Participant's response to examiner's question, "How disabling are the dyskinesias?", in the past week. (phv00076076.v1.p1)
  • Dyskinesia_Duration - Participant's response to examiner's question: "What proportion of the waking day are dyskinesias present?", in the past week. (phv00076075.v1.p1)
  • Dyskinesia_Pain - Participant's response to question, "How painful are the dyskinesias?", in the past week. (phv00076077.v1.p1)
  • Facial_Expression - Participant's score determined by examiner for facial expression while participant is in "on" or "off" state. (phv00076049.v1.p1)
  • Falling_Unrelated_to_Freezing - Participant's response to interview, indicating frequency of falling (not related to freezing) during the past week. (phv00076042.v1.p1)
  • family_history - Family history of PD. (phv00076000.v1.p1)
  • Finger_Taps_Left_Hand - Participant's score as determined by examiner for tapping of left thumb with index finger in rapid succession with widest amplitude possible while participant is in "on" or "off" state. (phv00076063.v1.p1)
  • Finger_Taps_Right_Hand - Participant's score determined by examiner for tapping of right thumb with index finger in rapid succession with widest amplitude possible while participant is in "on" or "off" state. (phv00076062.v1.p1)
  • Freezing_when_Walking - Participant's response to interview, indicating frequency of freezing during the past week. (phv00076043.v1.p1)
  • Gait - Participant's score determined by examiner for gait while participant is in "on" or "off" state. (phv00076072.v1.p1)
  • Hand_Movements_Left_Hand - Participant's score determined by examiner for opening and closing left hand in rapid succession with widest amplitude possible while participant is in "on" or "off" state. (phv00076065.v1.p1)
  • Hand_Movements_Right_Hand - Participant's score determined by examiner for opening and closing right hand in rapid succession with widest amplitude possible while participant is in "on" or "off" state. (phv00076064.v1.p1)
  • Handwriting - Participant's response to interview, indicating level of handwriting function during the past week. (phv00076037.v1.p1)
  • Hygiene - Participant's response to interview, indicating level of hygienic function during the past week. (phv00076040.v1.p1)
  • Left_Leg_Agility - Participant's score determined by examiner for tapping left heel on ground in rapid succession by lifting entire leg while participant is in "on" or "off" state. (phv00076069.v1.p1)
  • Motivation_Initiative - Participant's response to interview, indicating level of motivation/initiative during the past week. (phv00076033.v1.p1)
  • Postural_Stability - Participant's score determined by examiner for response to sudden posterior displacement produced by pull on shoulders when participant is erect, with eyes open and feet slightly apart (subject is prepared) while participant is in "on" or "off" state. (phv00076073.v1.p1)
  • Posture - Participant's score determined by examiner for posture while participant is in "on" or "off" state. (phv00076071.v1.p1)
  • Presence_of_early_morning_dystonia - Participant's response to the examiner's question about the presence or absence of early morning dystonia in the past week. (phv00076078.v1.p1)
  • Rapid_Alternating_Movements_of_Left_Hand - Participant's score determined by examiner for left hand pronation-supination movements, largest amplitude possible, both hands simultaneously while participant is in "on" or "off" state. (phv00076067.v1.p1)
  • Rapid_Alternating_Movements_of_Right_Hand - Participant's score determined by examiner for right hand pronation-supination movements, vertically or horizontally, with as large an amplitude as possible, both hands moving simultaneously while participant is in "on" or "off" state. (phv00076066.v1.p1)
  • Right_Leg_Agility - Participant's score determined by examiner for tapping right heel on ground in rapid succession by lifting entire leg while participant is in "on" or "off" state. (phv00076068.v1.p1)
  • Rigidity_LLE - Participant's score determined by examiner for rigidity in passive movement of lower left extremity with participant relaxed in sitting position while participant is in "on" or "off" state. (phv00076061.v1.p1)
  • Rigidity_LUE - Participant's score determined by examiner for rigidity in passive movement of upper left extremity with participant relaxed in sitting position while participant is in "on" or "off" state. (phv00076059.v1.p1)
  • Rigidity_Neck - Participant's score determined by examiner for rigidity in passive movement of neck with participant relaxed in sitting position while participant is in "on" or "off" state. (phv00076057.v1.p1)
  • Rigidity_RLE - Participant's score determined by examiner for rigidity in passive movement of lower right extremity with participant relaxed in sitting position while participant is in "on" or "off" state. (phv00076060.v1.p1)
  • Rigidity_RUE - Participant's score determined by examiner for rigidity in passive movement of upper right extremity with participant relaxed in sitting position while participant is in "on" or "off" state. (phv00076058.v1.p1)
  • Salivation - Participant's response to interview, indicating level of salivation during the past week. (phv00076035.v1.p1)
  • Sensory_Complaints_Related_to_Parkinsonism - Participant's response to interview, indicating sensory symptoms due to PD during the past week. (phv00076046.v1.p1)
  • Speech - Participant's response to interview, indicating level of speech function during the past week. (phv00076034.v1.p1)
  • Speech_Observed - Participant's score determined by examiner for speech ability while participant is in "on" or "off" state. (phv00076048.v1.p1)
  • Swallowing - Participant's response to interview, indicating level of swallowing function during the past week. (phv00076036.v1.p1)
  • Symptomatic_Orthostasis - Participant's response to examiner's question of whether or not the participant had symptomatic orthostasis in the past week. (phv00076085.v1.p1)
  • Tremor - Participant's response to interview, indicating presence of tremors during the past week. (phv00076045.v1.p1)
  • Tremor_at_Rest_Face_Lips_Chin - Participant's score determined by examiner for resting tremor in face, lips, and chin while participant is in "on" or "off" state. (phv00076050.v1.p1)
  • Tremor_at_Rest_Left_Foot - Participant's score determined by examiner for resting tremor in left foot while participant is in "on" or "off" state. (phv00076054.v1.p1)
  • Tremor_at_Rest_Left_Hand - Participant's score determined by examiner for resting tremor in left hand while participant is in "on" or "off" state. (phv00076052.v1.p1)
  • Tremor_at_Rest_Right_Foot - Participant's score determined by examiner for resting tremor in right foot while participant is in "on" or "off" state. (phv00076053.v1.p1)
  • Tremor_at_Rest_Right_Hand - Participant's score determined by examiner for resting tremor in right hand while participant is in "on" or "off" state. (phv00076051.v1.p1)
  • Turning_in_Bed_and_Adjusting_Bedclothes - Participant's response to interview, indicating level of ability to turn in bed during the past week. (phv00076041.v1.p1)
  • UKBB_Bradykinesia - Bradykinesia (slowness of initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions) (phv00076419.v1.p1)
  • UKBB_Clinical_course_of_10_years_or_more - Clinical course of 10 years or more (phv00076430.v1.p1)
  • UKBB_Excellent_response_(70_100%)_to_levodopa_or_dopamine_agonist - Excellent response (70-100%) to levodopa or dopamine agonist (phv00076427.v1.p1)
  • UKBB_Exclusion_Criteria - Subject has any of the following exclusion criteria for Parkinson's disease: history of repeated strokes with stepwise progression of parkinsonian features; history of repeated head injury; history of definite encephalitis; oculogyric crises; neuroleptic treatment at onset of symptoms; sustained remission; strictly unilateral features after 3 years; Supranuclear gaze palsy; cerebellar signs; early severe autonomic involvement; Early severe dementia with disturbances of memory, language, and praxis; babinski sign; Presence of cerebral tumor or communication hydrocephalus on CT scan; negative response to large doses of levodopa (if malabsorption excluded); MPTP exposure (phv00076423.v1.p1)
  • UKBB_individual_criteria - Subjects with individual UK Brain Bank criteria (phv00076418.v1.p1)
  • UKBB_Levodopa_response_for_5_years_or_more - Levodopa or dopamine agonist response for 5 years or more (phv00076429.v1.p1)
  • UKBB_Persistent_asymetry_affecting_side_of_onset_most - Persistent asymmetry affecting side of onset most (phv00076426.v1.p1)
  • UKBB_Postural_Instability - Postural instability not caused by primary visual, vestibular, cerebellar, or proprioceptive dysfunction (phv00076422.v1.p1)
  • UKBB_Progressive_disorder - Progressive disorder (phv00076425.v1.p1)
  • UKBB_Resting_Tremor - 4-6 Hz rest tremor (phv00076421.v1.p1)
  • UKBB_Rigidity - Muscular rigidity (phv00076420.v1.p1)
  • UKBB_Severe_levodopa_induced_chorea - Severe levodopa-induced chorea (phv00076428.v1.p1)
  • UKBB_Unilateral_Onset - Unilateral onset (phv00076424.v1.p1)
  • UPDRS - Participants with a Unified Parkinson's Disease Rating Scale score. (phv00076028.v1.p1)
  • Walking - Participant's response to interview, indicating walking ability during the past week. (phv00076044.v1.p1)

Geography (1)

Medications (4)

  • NSAIDs_OTC_ever_never - Did participant ever consume over the counter (non-aspirin) non-steroidal anti-inflammatory drugs? (phv00076015.v1.p1)
  • NSAIDs_OTC_load - Lifetime over the counter (non-aspirin) non-steroidal anti-inflammatory drug consumption. (phv00076016.v1.p1)
  • NSAIDs_Rx_ever_never - Did participant ever consume prescription (non-aspirin) non-steroidal anti-inflammatory drugs? (phv00076017.v1.p1)
  • NSAIDs_Rx_load - Lifetime prescription (non-aspirin) non-steroidal anti-inflammatory drug consumption. (phv00076018.v1.p1)

Mental Health (6)

  • Depression - Participant's response to interview, indicating level of depression during the past week. (phv00076032.v1.p1)
  • Intellectual_Impairment - Participant's response to interview, indicating level of intellectual impairment during the past week. (phv00076030.v1.p1)
  • MMSE - Participants with a Mini Mental State Exam score. (phv00076024.v1.p1)
  • MMSE_in-person - Mini Mental State Exam score administered in-person. (phv00076026.v1.p1)
  • MMSE_telephone - Mini Mental State Exam score administered by telephone. (phv00076027.v1.p1)
  • Thought_Disorder - Participant's response to interview, indicating level of thought disorders during the past week. (phv00076031.v1.p1)

Race and Ethnicity (1)

Sleep (1)

  • Sleep_Disturbances - Participant's response to examiner's question of whether or not the participant had sleep disturbances in the past week. (phv00076084.v1.p1)

Substance Use (3)

Other (32)