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National Cancer Institute Cancer Genome Characterization Initiative (CGCI)

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Frequent mutation of histone modifying genes in non-Hodgkin lymphoma

Ryan D. Morin, María Méndez-Lago, A. Mungall, et al. (2011). Nature. Cited 1,619 times. https://doi.org/10.1038/nature10351

Somatic mutation of EZH2 (Y641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal Center Origin

Ryan D. Morin, N. Johnson, T. Severson, et al. (2010). Nature genetics. Cited 921 times. https://doi.org/10.1038/ng.518

The Genetic Landscape of the Childhood Cancer Medulloblastoma

D. W. Parsons, M. Li, Xiaosong Zhang, et al. (2011). Science. Cited 730 times. https://doi.org/10.1126/science.1198056

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Damian Boon Siew Yap, Justin Chu, T. Berg, et al. (2011). Blood. Cited 613 times. https://doi.org/10.1182/blood-2010-11-321208