Carcinoma, Ductal, Breast study with SNP Genotypes (Array), mRNA Expression (Array) + 2 more data on dbGaP (108 participants)

phs000369 — Sequence Analysis of Mutations and Translocations Across Breast Cancer    Subtypes

<p>This study combined whole exome (103 samples) and whole genome (22 samples) sequencing over a total of 108 breast tumors and     matched normal DNA to identify novel mutations and translocations.  Samples were subjected to paired-end Illumina sequencing     with goal of 30x coverage of tumor/normal for whole genomes and 100x tumor/normal coverage for whole exomes.  From these     sequences, we used various computational techniques to identify somatic point mutations, insertion/deletions and structural     rearrangements in these tumors.  From these data, we identified new insights into the rates of background mutations in these     cancers, novel recurrent mutated genes, and multiple gene rearrangements.  One of these rearrangements appears to be a     recurrent event in breast cancer.</p>