Leukemia, Lymphocytic, Chronic, B-Cell study with Bisulfite-Seq, RNA-Seq + 2 more data on dbGaP (35 participants)

phs001431 — Whole Exome and Whole Genome Profiling as well Genome-Wide Methylation    Profiling from Early to Advanced Chronic Lymphocytic leukemia (CLL),    Genome-Wide Methylation Profiling in Monoclonal B Cell Lymphocytosis    (MBL)

<p>Serial whole exome sequencing of samples collected from 21 patients at multiple time points during progression from early to late chronic lymphocytic leukemia (CLL) and one matching non-tumor tissue sample from each patient. Additional whole genome sequencing of samples from 3 selected patients.</p> <p>Genome-wide B cell methylation compared between 5 healthy donors from the same age group as patients, 20 patients with monoclonal B cell lymphocytosis and in serial CLL samples with matching whole exome sequencing. Moreover, genome-wide single-cell RRBS-profiling of B cells from one healthy donor and from one patient with CLL was performed using a protocol newly developed by the A. Meissner group.</p>

Whole Exome and Whole Genome Profiling as well Genome-Wide Methylation    Profiling from Early to Advanced Chronic Lymphocytic leukemia (CLL),    Genome-Wide Methylation Profiling in Monoclonal B Cell Lymphocytosis    (MBL)