Adenocarcinoma Of Esophagus study with SNP Genotypes (Array) data on dbGaP (28 participants)

phs001454 — Genomic Regions Associated with Susceptibility to Barrett's Esophagus and    Esophageal Adenocarcinoma in African Americans: The Cross BETRNet    Admixture Study

<p>Differences in rates of diseases between different populations with similar environments are presumed to be secondary to variability in population frequencies of disease causing alleles. Recently admixed populations such as African Americans (AAs) provide a natural opportunity to identify disease-causing variants by examining the ancestry of long chromosomal haplotypes. Admixture mapping approach can be successful in locating genes for diseases such as EAC whose rates varies markedly between the ancestral populations. This is a case only study with 54 African American cases and also on a subset of 28 cases with high genotyping quality. We seek to identify chromosome regions that have excess European ancestry and contrasting it to excess African ancestry. </p>

Genomic Regions Associated with Susceptibility to Barrett's Esophagus and    Esophageal Adenocarcinoma in African Americans: The Cross BETRNet    Admixture Study