Pediatric Obesity study with Methylation (CpG), SNP/CNV (Array) data on dbGaP (505 participants)

phs001498 — INSIGHT (Intervention Nurses Start Infants Growing on Healthy    Trajectories) Cohort

This is a study of the biological risk factors for children enrolled in <a href="https://hhd.psu.edu/nutrition/insight-study">the INSIGHT (Intervention Nurses Start Infants Growing on Healthy Trajectories) study</a>. INSIGHT is a randomized, controlled trial testing a responsive parenting intervention designed for the primary prevention of childhood obesity against a safety control. These first-born children were deeply studied in this time period with data collected on a wide variety of variables including mode of delivery, gender, weight and height (collected at 7 time points), medication usage, diet information, and maternal health information (gestational weight gain, gestational diabetes, smoking during pregnancy). This study includes a survey of the oral and gut microbiota from 226 mother-child dyads. It was designed to investigate the relationship between a cross-sectional view of the child's microbiome (at two years of age) and the patterns of growth between birth and 2 years. Microbiome samples from children (buccal swab and stool sample) and their mothers (buccal swab) are collected at the children's 2-year clinical research visit. Stool metabolites have also been assayed for a subset of the 226 children using 1H-NMR. Additionally, we genotyped the same individuals for SNPs across the genome. For a subset of 48 individuals we have added second-born siblings. For these additional 48 children, we characterized the methylation pattern across the genome using cord blood and placenta samples.