Genomic Diagnosis and Individualized Therapy of Monogenic Diabetes

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Anthropometry (6)

obese_at_dx - Were you obese when you were diagnosed with diabetes? (version 2) OR Was your BMI higher than 30 when you were diagnosed with diabetes? (version 3) OR Were you extremely overweight when you were diagnosed with diabetes? (version 4-6) (phv00400519.v1.p1)
PHHQ40 - Current Height (phv00400579.v1.p1)
PHHQ41 - Current Weight (phv00400580.v1.p1)
PHHQ42 - Height at time of diagnosis (phv00400581.v1.p1)
PHHQ43 - Weight at time of diagnosis (phv00400583.v1.p1)
PHHQ9 - Obesity (phv00400544.v1.p1)

Biomarkers (2)

PHHQ4 - High cholesterol or lipids (phv00400539.v1.p1)
PHHQ62 - What is your most recent Hemoglobin A1c? (phv00400628.v1.p1)

Demographics (4)

age - Age - study site 1 (phv00400504.v1.p1)
age_diagnosed - How old were you when you were diagnosed with diabetes? (phv00400517.v1.p1)
age_nodob - Age - study site 2 - 4 (phv00400505.v1.p1)
gender - Gender (phv00400506.v1.p1)

Disease Events (36)

other_diagnosis - Age of other non-diabetic blood sugar disorder diagnosis. (phv00400518.v1.p1)
parent_child_sp___1 - Parent with Type 1 Diabetes (phv00400525.v1.p1)
parent_child_sp___2 - Child with Type 1 Diabetes (phv00400526.v1.p1)
parent_child_type1 - Do you have a parent or a child with Type 1 Diabetes? (versions 4 - 6) (phv00400524.v1.p1)
parent_type1 - Do you have a parent with type 1 diabetes? (version 2 and 3) (phv00400523.v1.p1)
PHHQ1 - Stroke (phv00400536.v1.p1)
PHHQ10 - Pancreatitis or pancreas surgery (phv00400545.v1.p1)
PHHQ11 - Liver disease (cirrhosis, hepatitis, fatty liver, abnormal liver tests) (phv00400546.v1.p1)
PHHQ12 - Kidney disease (phv00400547.v1.p1)
PHHQ13 - Kidney failure or transplant (phv00400548.v1.p1)
PHHQ17 - Thyroid problems (phv00400551.v1.p1)
PHHQ18 - Anemia or bleeding disorder (phv00400552.v1.p1)
PHHQ2 - High blood pressure (phv00400537.v1.p1)
PHHQ22 - Circulation problems (major leg cramps, leg sores, amputation) (phv00400556.v1.p1)
PHHQ24 - Cancer or tumors (phv00400558.v1.p1)
PHHQ25 - Genetic disorder (phv00400559.v1.p1)
PHHQ3 - Heart disease (angina, bypass, heart attack, angioplasty) (phv00400538.v1.p1)
PHHQ30 - Polycystic ovary syndrome (PCOS), ovarian cysts or other ovarian disorder (phv00400563.v1.p1)
PHHQ32 - Cystic Fibrosis (phv00400565.v1.p1)
PHHQ33 - Hearing loss (phv00400566.v1.p1)
PHHQ34 - Vision loss (phv00400567.v1.p1)
PHHQ35 - Intellectual disability, learning problem, special education classes (phv00400568.v1.p1)
PHHQ38A - Type 1 diabetes (phv00400569.v1.p1)
PHHQ38B - Type 2 diabetes (phv00400570.v1.p1)
PHHQ38C - Gestational diabetes (phv00400571.v1.p1)
PHHQ5 - Epilepsy or seizures (phv00400540.v1.p1)
PHHQ6 - Asthma or lung disease (phv00400541.v1.p1)
PHHQ7 - Gallstones or gallbladder disease (phv00400542.v1.p1)
PHHQ8 - Stomach ulcers or colitis, inflammatory bowel disease (phv00400543.v1.p1)
type_diagnosis___1 - Have you been diagnosed with the following? (check all that apply) - Type 1 Diabetes (phv00400509.v1.p1)
type_diagnosis___2 - Have you been diagnosed with the following? (check all that apply) - Type 2 Diabetes (phv00400510.v1.p1)
type_diagnosis___3 - Have you been diagnosed with the following? (check all that apply) - Gestational Diabetes (phv00400511.v1.p1)
type_diagnosis___4 - Have you been diagnosed with the following? (check all that apply) - Pre-diabetes or high blood sugar (phv00400512.v1.p1)
type_diagnosis___5 - Have you been diagnosed with the following? (check all that apply) - Other (phv00400513.v1.p1)
type1_diabetes - Do you have type 1 diabetes? (phv00400522.v1.p1)
type2_diabetes - Do you have 2 or more people related to you by blood with diabetes? (phv00400527.v1.p1)

General Health (4)

PHHQ15 - Joint or muscular problems (phv00400549.v1.p1)
PHHQ16 - Osteoporosis (phv00400550.v1.p1)
PHHQ27 - Surgery in childhood (specify) (phv00400560.v1.p1)
PHHQ28 - SURGERY IN ADULTHOOD (phv00400561.v1.p1)

Geography (1)

study_site - Study Site (phv00400501.v1.p1)

Medications (33)

PHHQ45A - Insulin (phv00400593.v1.p1)
PHHQ45B - Insulin-did you take this in the first 6 months after you were diagnosed (phv00400594.v1.p1)
PHHQ45C - Insulin-do you currently take this (phv00400595.v1.p1)
PHHQ46A - Glipizide (Glucotrol, Glucotrol XL), glyburide (Micronase, Glynase, Diabeta), (phv00400596.v1.p1)
PHHQ46B - Glipizide-did you take this in the first 6 months after you were diagnosed (phv00400597.v1.p1)
PHHQ46C - Glipizide-do you currently take this (phv00400598.v1.p1)
PHHQ47A - Metformin (Glucophage) (phv00400599.v1.p1)
PHHQ47B - Metformin-did you take this in the first 6 months after you were diagnosed (phv00400600.v1.p1)
PHHQ47C - Metformin (Glucophage)-do you currently take this (phv00400601.v1.p1)
PHHQ48A - Repaglinide (Prandin), nateglinide (Starlix) (phv00400602.v1.p1)
PHHQ48B - Repaglinide-did you take this in the first 6 months after you were diagnosed (phv00400603.v1.p1)
PHHQ48C - Repaglinide (Prandin), pioglitazone (Actos)-do you currently take this (phv00400604.v1.p1)
PHHQ49A - Rosiglitazone (Avandia), pioglitazone (Actos) (phv00400605.v1.p1)
PHHQ49B - Rosiglitazone-did you take this in the first 6 months after you were diagnosed (phv00400606.v1.p1)
PHHQ49C - Rosiglitazone (Avandia), pioglitazone (Actos)-do you currently take this (phv00400607.v1.p1)
PHHQ50A - Sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (phv00400608.v1.p1)
PHHQ50B - Sitagliptin -did you take this in the first 6 months after you were diagnosed (phv00400609.v1.p1)
PHHQ50C - Sitagliptin-do you currently take this (phv00400610.v1.p1)
PHHQ51A - Canagliflozin (Invokana), dapagliflozin (Farxiga) (phv00400611.v1.p1)
PHHQ51B - Canagliflozin-did you take this in the first 6 months after you were diagnosed (phv00400612.v1.p1)
PHHQ51C - Canagliflozin (Invokana), dapagliflozin (Farxiga)-do you currently take this (phv00400613.v1.p1)
PHHQ52A - Exenatide (Byetta, Bydureon), liraglutide (Victoza) (phv00400614.v1.p1)
PHHQ52B - Exenatide-did you take this in the first 6 months after you were diagnosed (phv00400615.v1.p1)
PHHQ52C - Exenatide (Byetta, Bydureon), liraglutide (Victoza)-do you currently take this (phv00400616.v1.p1)
PHHQ53A - Pramlintide (Symlin) (phv00400617.v1.p1)
PHHQ53B - Pramlintide-did you take this in the first 6 months after you were diagnosed (phv00400618.v1.p1)
PHHQ53C - Pramlintide (Symlin)-do you currently take this (phv00400619.v1.p1)
PHHQ54A - Acarbose (Precose), meglitol (Glyset) (phv00400620.v1.p1)
PHHQ54B - Acarbose-did you take this in the first 6 months after you were diagnosed (phv00400621.v1.p1)
PHHQ54C - Acarbose (Precose), meglitol (Glyset)-do you currently take this (phv00400622.v1.p1)
PHHQ55A - Colesevelam (Welchol) (phv00400623.v1.p1)
PHHQ55B - Colesevelam-did you take this in the first 6 months after you were diagnosed (phv00400624.v1.p1)
PHHQ55C - Colesevelam (Welchol)-do you currently take this (phv00400625.v1.p1)

Race and Ethnicity (2)

ethnicity - Ethnicity (phv00400507.v1.p1)
race - Race (phv00400508.v1.p1)

Other (52)

ANALYTE_TYPE - Analyte Type (phv00400632.v1.p1)
before_1_combined - Were you diagnosed with diabetes(versions 2-5)/diabetes or high blood sugar(version 6) before 1 year of age? (phv00400515.v1.p1)
before_30_combined - Were you diagnosed with diabetes (versions 2-5)/diabetes or high blood sugar(version 6) before 30 year of age? (phv00400516.v1.p1)
BODY_SITE - Body site where sample was collected (phv00400631.v1.p1)
child_problems_sp - Specify childhood problems (phv00400521.v1.p1)
childhood_problems - As a child, did/do you have hearing or vision problems, an intellectual disability, birth defect(s), or kidney disease? (phv00400520.v1.p1)
CONSENT - Consent group as determined by DAC (phv00400497.v1.p1)
cpeptide - C-Peptide (phv00400530.v1.p1)
cpeptide_units - C-Peptide Units (phv00400531.v1.p1)
gad65 - GAD 65 autoantibody (U/mL) (phv00400529.v1.p1)
glucose - Glucose (mg/dl) on day of C-peptide measurement (phv00400532.v1.p1)
group - What is the participant's group assignment? (phv00400534.v1.p1)
group_assignment - What type of variant does the proband have? (phv00400535.v1.p1)
HISTOLOGICAL_TYPE - Cell or tissue type or subtype of sample (phv00400634.v1.p1)
ia2 - IA2 antibodies (U/ml) (phv00400528.v1.p1)
IS_TUMOR - Tumor status (phv00400633.v1.p1)
mody_panel - Is monogenic diabetes panel indicated? (phv00400533.v1.p1)
participant_source - Participant Source (phv00400502.v1.p1)
PHHQ19 - Skin problems (eczema, hyperpigmentation) (phv00400553.v1.p1)
PHHQ20 - Diabetic ketoacidosis (phv00400554.v1.p1)
PHHQ21 - Diabetes related eye problems (retinopathy) (phv00400555.v1.p1)
PHHQ23 - Diabetes related neuropathy (tingling, numbness, or burning in hands/feet) (phv00400557.v1.p1)
PHHQ29 - Birth defects (phv00400562.v1.p1)
PHHQ31 - Hypogonadism; delayed or absent puberty; precocious puberty (phv00400564.v1.p1)
PHHQ38C1 - High Blood Sugar without diabetes diagnosis (phv00400572.v1.p1)
PHHQ38D - OTHER TYPE OF DIABETES (phv00400574.v1.p1)
PHHQ38DS - OTHER TYPE OF DIABETES (SPECIFY) (phv00400573.v1.p1)
PHHQ38E - OTHER TYPE OF DIABETES (phv00400576.v1.p1)
PHHQ38ES - OTHER TYPE OF DIABETES (SPECIFY) (phv00400575.v1.p1)
PHHQ39 - Have you ever been told or suspected that you might have a "special" type (phv00400577.v1.p1)
PHHQ39SP - HAVE YOU EVER BEEN TOLD OR SUSPECTED THAT YOU MIGHT HAVE SPECIAL TYPE OF DIABETES, SPECIFY (phv00400578.v1.p1)
PHHQ42U - Height at diagnosis-unknown (phv00400582.v1.p1)
PHHQ43U - Weight at diagnosis-unknown (phv00400584.v1.p1)
PHHQ44A - Diabetic Ketoacidosis/hospitalization to ICU for diabetes (phv00400585.v1.p1)
PHHQ44B - Routine physician visit/blood work (phv00400586.v1.p1)
PHHQ44C - Testing during pregnancy (phv00400587.v1.p1)
PHHQ44D - Symptoms (excessive thirst or urination) (phv00400588.v1.p1)
PHHQ44E - Testing because of risk factors (e.g., obesity, triglycerides) (phv00400589.v1.p1)
PHHQ44F - Diagnosis in a family member (phv00400590.v1.p1)
PHHQ44G - Other (specify) (phv00400591.v1.p1)
PHHQ44SP - WHAT WERE THE FACTORS LEADING TO YOUR DIABETES DIAGNOSIS, OTHER (phv00400592.v1.p1)
PHHQ59 - What is the highest grade or level of school you completed (phv00400626.v1.p1)
PHHQ60 - Marital Status (phv00400627.v1.p1)
PHHQ62A - What is your most recent Hemoglobin A1c? - unknown (phv00400629.v1.p1)
SAMPLE_ID - De-identified Sample ID (phv00400630.v1.p1)
SAMPLE_ID - Sample ID (phv00400499.v1.p1)
SEQUENCING_CENTER - Name of the center which conducted sequencing (phv00400635.v1.p1)
SUBJECT_ID - De-identified Subject ID (phv00400500.v1.p1)
SUBJECT_ID - Subject ID (phv00400496.v1.p1)
SUBJECT_ID - Subject ID (phv00400498.v1.p1)
type_oth_sp - Please specify other diagnosis (phv00400514.v1.p1)
version - Intake Questionnaire Version (phv00400503.v1.p1)