Wilms Tumor study with Methylation (CpG), RNA Seq (NGS) + 1 more data on dbGaP (14 participants)

phs002769 — Multi-Omic Investigation of Beckwith-Wiedemann Syndrome Wilms Tumor

<p>Wilms’ Tumor (WT), also known as nephroblastoma, is one of the most common malignant kidney tumors diagnosed in children. One of the most common WT predisposition syndromes is Beckwith-Wiedemann Syndrome (BWS, OMIM: <a href="https://www.omim.org/entry/130650?search=130650&#x26;highlight=130650">130650</a>), which affects approximately 1/10,000 live births. In this study, we perform Whole Exome Sequencing (WES), DNA methylation array, and messenger RNA-Sequencing (mRNA-Seq), to examine the genomic, methylomic, and transcriptomic signature of BWS WT. We analyzed six tumor-normal paired samples, three BWS tumor only samples, and four non-BWS control samples to identify BWS WT drivers. </p>