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Pharmacogenomics of Mercaptopurine Intolerance in Children with Acute Lymphoblastic Leukemia (AALL03N1)

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Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

Jun J. Yang, W. Landier, Wenjian Yang, et al. (2015). Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Cited 393 times. https://doi.org/10.1200/JCO.2014.59.4671

Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study.

S. Bhatia, S. Bhatia, W. Landier, et al. (2015). JAMA oncology. Cited 133 times. https://doi.org/10.1001/jamaoncol.2015.0245

Effects of NT5C2 germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemia

Chuang Jiang, Wenjian Yang, Takaya Moriyama, et al. (2020). bioRxiv. Cited 9 times. https://doi.org/10.1002/cpt.2095