Ovarian Neoplasms study with RNA-Seq, WXS data on dbGaP (657 participants)

phs003632 — Whole Exome Sequencing and RNA Sequencing of High Grade Serous Ovarian    Cancer in Black and White Patients

<p>In this study, we generated new RNA and whole exome sequencing data from high-grade serous ovarian cancer tumor samples of self-identified Black and White individuals. Our RNA-Seq analysis revealed that, while the prevalence of subtypes varied across racial groups, the cluster-specific gene expression patterns were consistent. Despite these differences in subtype prevalence, the subtype-specific survival rates were similar across racial groups. Additionally, we used the WES-Seq data to characterize mutational signatures and their underlying causes in Black high-grade serous ovarian cancer (HGSC) cases, and compared the prevalence and distribution of these signatures with those in White TCGA cases.</p>