Arsenic study with Methylation (CpG), SNP/CNV (Array) data on dbGaP (3,526 participants)

phs003839 — Health Effects of Arsenic Longitudinal Study

<p>The Health Effects of Arsenic Longitudinal Study (HEALS), a multidisciplinary and large prospective cohort study in Araihazar, Bangladesh, was established to evaluate the effects of full-dose range arsenic (As) exposure on various health outcomes. We applied array-based genotyping technologies to baseline DNA samples from a subset of the HEALS study and linked those genotypes to data on arsenic species measured in urine. We used these data to identify regions influencing arsenic metabolism (<a href="https://www.ncbi.nlm.nih.gov/gene/57412">AS3MT </a>and <a href="https://www.ncbi.nlm.nih.gov/gene/10841">FTCD</a>). We also applied array-based DNA methylation technologies to baseline DNA samples from a subset of individuals from HEALS. These data were linked to data on arsenic concentration (in both urine and drinking water) to identify regions of the genome where DNA methylation is impacted by arsenic exposure. </p>