The goal of this collaborative study is to combine the resources and expertise of three groups with long-standing studies of psoriasis genetics in order to identify new genetic susceptibility factors for psoriasis, a common inflammatory skin disease that affects over 4 million Americans. Consent groups and participant set <ul> <li>General research use (GRU): 1677 (950 cases, 692 controls, 35 others)</li> <li>Autoimmune disease (AD): 1198 (449 cases, 734 controls, 15 others)</li> </ul>

Collaborative Association Study of Psoriasis

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.

A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis