T1DGC: Genome-Wide Association Study in Type 1 Diabetes, 2008

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

H. Ueda, J. Howson, L. Esposito, et al.. (2003). Nature. Cited 2,309 times. https://doi.org/10.1038/nature01621

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

J. Todd, N. Walker, J. Cooper, et al.. (2007). Nature Genetics. Cited 1,532 times. https://doi.org/10.1038/ng2068

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

S. Nejentsev, N. Walker, D. Riches, et al.. (2009). Science. Cited 1,023 times. https://doi.org/10.1126/science.1167728

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

D. Smyth, V. Plagnol, N. Walker, et al.. (2008). The New England journal of medicine. Cited 697 times. https://doi.org/10.1056/NEJMoa0807917

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

D. Smyth, J. Cooper, Rebecca Bailey, et al.. (2006). Nature Genetics. Cited 680 times. https://doi.org/10.1038/ng1800

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

S. Nejentsev, J. Howson, N. Walker, et al.. (2007). Nature. Cited 579 times. https://doi.org/10.1038/nature06406

Population structure, differential bias and genomic control in a large-scale, case-control association study

D. Clayton, N. Walker, D. Smyth, et al.. (2005). Nature Genetics. Cited 568 times. https://doi.org/10.1038/ng1653

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.

D. Smyth, J. Cooper, J. Collins, et al.. (2004). Diabetes. Cited 542 times. https://doi.org/10.2337/DIABETES.53.11.3020

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

J. Cooper, D. Smyth, A. Smiles, et al.. (2008). Nature Genetics. Cited 530 times. https://doi.org/10.1038/ng.249

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

C. Lowe, J. Cooper, T. Brusko, et al.. (2007). Nature Genetics. Cited 456 times. https://doi.org/10.1038/ng2102

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.

A. Vella, J. Cooper, C. Lowe, et al.. (2005). American journal of human genetics. Cited 366 times. https://doi.org/10.1086/429843

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

Erik Fung, D. Smyth, J. Howson, et al.. (2009). Genes and Immunity. Cited 274 times. https://doi.org/10.1038/gene.2008.99

CD226 Gly307Ser association with multiple autoimmune diseases

J. Hafler, L. Maier, J. D. Cooper, et al.. (2009). Genes and Immunity. Cited 244 times. https://doi.org/10.1038/gene.2008.82

Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes

Rebecca Bailey, J. Cooper, L. Zeitels, et al.. (2007). Diabetes. Cited 202 times. https://doi.org/10.2337/db07-0652

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

P. Concannon, Suna Onengut-Gumuscu, J. Todd, et al.. (2008). Diabetes. Cited 124 times. https://doi.org/10.2337/db08-0753

Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13

V. Plagnol, D. Smyth, J. Todd, et al.. (2008). Biostatistics (Oxford, England). Cited 111 times. https://doi.org/10.1093/biostatistics/kxn039

Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.

S. Nejentsev, J. Cooper, L. Godfrey, et al.. (2004). Diabetes. Cited 94 times. https://doi.org/10.2337/DIABETES.53.10.2709

PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes

D. Smyth, J. Cooper, J. Howson, et al.. (2008). Diabetes. Cited 88 times. https://doi.org/10.2337/db07-1131

Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.

L. Maier, J. Howson, N. Walker, et al.. (2006). The Journal of allergy and clinical immunology. Cited 84 times. https://doi.org/10.1016/J.JACI.2005.12.1354

Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects

Sarah F. Field, J. Howson, D. Smyth, et al.. (2006). Diabetologia. Cited 73 times. https://doi.org/10.1007/s00125-006-0506-y

A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene

J. Howson, D. Dunger, S. Nutland, et al.. (2007). Diabetologia. Cited 72 times. https://doi.org/10.1007/s00125-007-0603-6

Contrasting genetic association of IL2RA with SLE and ANCA – associated vasculitis

E. J. Carr, M. Clatworthy, C. Lowe, et al.. (2009). BMC Medical Genetics. Cited 70 times. https://doi.org/10.1186/1471-2350-10-22

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

D. Smyth, Joanna M M Howson, F. Payne, et al.. (2006). BMC Medical Genetics. Cited 62 times. https://doi.org/10.1186/1471-2350-7-20

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

D. Smyth, J. Howson, C. Lowe, et al.. (2005). Nature Genetics. Cited 57 times. https://doi.org/10.1038/ng0205-110

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

J. Cooper, D. Smyth, Rebecca Bailey, et al.. (2007). BMC Medical Genetics. Cited 53 times. https://doi.org/10.1186/1471-2350-8-71

Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls

Sarah F. Field, J. Howson, N. Walker, et al.. (2007). Diabetologia. Cited 51 times. https://doi.org/10.1007/s00125-007-0767-0

No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

L. Maier, Juliet M Chapman, J. Howson, et al.. (2005). American journal of human genetics. Cited 50 times. https://doi.org/10.1086/428387

Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.

Jeffrey S. Szeszko, J. Howson, J. Cooper, et al.. (2006). Diabetes. Cited 41 times. https://doi.org/10.2337/DIABETES.55.02.06.DB05-0826

No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility

Rebecca Pask, J. Cooper, N. Walker, et al.. (2006). Diabetes/Metabolism Research and Reviews. Cited 37 times. https://doi.org/10.1002/dmrr.628

Sequencing-Based Genotyping and Association Analysis of the MICA and MICB Genes in Type 1 Diabetes

Sarah F. Field, S. Nejentsev, N. Walker, et al.. (2008). Diabetes. Cited 37 times. https://doi.org/10.2337/db07-1402

No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases

D. Smyth, J. Cooper, C. Lowe, et al.. (2006). Diabetes. Cited 16 times. https://doi.org/10.2337/db05-1452

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes

F. Payne, J. Cooper, N. Walker, et al.. (2007). Journal of Leukocyte Biology. Cited 15 times. https://doi.org/10.1189/jlb.0906577

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes

H. Taniguchi, C. Lowe, J. Cooper, et al.. (2006). BMC Genetics. Cited 14 times. https://doi.org/10.1186/1471-2156-7-22

Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900–905

Lisa M. Maier, Jonathan D. Cooper, N. Walker, et al.. (2005). Diabetologia. Cited 10 times. https://doi.org/10.1007/s00125-005-1906-0

Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11

S. Nejentsev, L. Smink, D. Smyth, et al.. (2007). BMC Genetics. Cited 10 times. https://doi.org/10.1186/1471-2156-8-24

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Lisa M. Maier, D. Smyth, Adrian Vella, et al.. (2005). BMC Genetics. Cited 4 times. https://doi.org/10.1186/1471-2156-6-9