Genetic Studies in the Hutterites

Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.

C. Ober, Z. Tan, Ying Sun, et al.. (2008). The New England journal of medicine. Cited 499 times. https://doi.org/10.1056/NEJMoa0708801

The sex-specific genetic architecture of quantitative traits in humans

L. Weiss, Lin Pan, M. Abney, et al.. (2006). Nature Genetics. Cited 438 times. https://doi.org/10.1038/ng1726

A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.

C. Ober, A. Tsalenko, R. Parry, et al.. (2000). American journal of human genetics. Cited 373 times. https://doi.org/10.1016/S0002-9297(07)62946-2

Taxonomic Classification of Bacterial 16S rRNA Genes Using Short Sequencing Reads: Evaluation of Effective Study Designs

Orna Mizrahi-Man, Emily R. Davenport, Y. Gilad. (2013). PLoS ONE. Cited 308 times. https://doi.org/10.1371/journal.pone.0053608

Seasonal Variation in Human Gut Microbiome Composition

Emily R. Davenport, Orna Mizrahi-Man, K. Michelini, et al.. (2014). PLoS ONE. Cited 286 times. https://doi.org/10.1371/journal.pone.0090731

Genome-Wide Association Studies of the Human Gut Microbiota

Emily R. Davenport, D. Cusanovich, K. Michelini, et al.. (2015). PLoS ONE. Cited 229 times. https://doi.org/10.1371/journal.pone.0140301

The genetic dissection of complex traits in a founder population.

C. Ober, M. Abney, M. McPeek. (2001). American journal of human genetics. Cited 204 times. https://doi.org/10.1086/324025

Estimation of variance components of quantitative traits in inbred populations.

M. Abney, M. McPeek, Carole Ober. (2000). American journal of human genetics. Cited 152 times. https://doi.org/10.1086/302759

Genome-wide association study identifies candidate genes for male fertility traits in humans.

Gülüm Kosova, Nicole M. Scott, C. Niederberger, et al.. (2012). American journal of human genetics. Cited 137 times. https://doi.org/10.1016/j.ajhg.2012.04.016

Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.

M. Abney, C. Ober, M. McPeek. (2002). American journal of human genetics. Cited 117 times. https://doi.org/10.1086/339705

Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13.

Minal Çalışkan, Jessica X. Chong, Lawrence H. Uricchio, et al.. (2011). Human molecular genetics. Cited 114 times. https://doi.org/10.1093/hmg/ddq569

Heritability of reproductive fitness traits in a human population

Gülüm Kosova, M. Abney, C. Ober. (2010). Proceedings of the National Academy of Sciences. Cited 95 times. https://doi.org/10.1073/pnas.0906196106

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

David A. Knowles, Courtney K Burrows, J. Blischak, et al.. (2017). eLife. Cited 93 times. https://doi.org/10.7554/eLife.33480

A comparison of humans and baboons suggests germline mutation rates do not track cell divisions

Felix L. Wu, Alva I. Strand, C. Ober, et al.. (2019). PLoS Biology. Cited 81 times. https://doi.org/10.1371/journal.pbio.3000838

Host genetic variation in mucosal immunity pathways influences the upper airway microbiome

C. Igartua, Emily R. Davenport, Y. Gilad, et al.. (2016). Microbiome. Cited 76 times. https://doi.org/10.1186/s40168-016-0227-5

A population-based study of autosomal-recessive disease-causing mutations in a founder population.

Jessica X. Chong, Rebecca Ouwenga, Rebecca L. Anderson, et al.. (2012). American journal of human genetics. Cited 61 times. https://doi.org/10.1016/j.ajhg.2012.08.007

The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes

D. Cusanovich, C. Billstrand, Xiang Zhou, et al.. (2012). Human Molecular Genetics. Cited 60 times. https://doi.org/10.1093/hmg/dds021

Heritability estimation of sex‐specific effects on human quantitative traits

Lin Pan, C. Ober, M. Abney. (2007). Genetic Epidemiology. Cited 53 times. https://doi.org/10.1002/GEPI.20214

Whole-Genome Sequencing of Individuals from a Founder Population Identifies Candidate Genes for Asthma

Catarina D. Campbell, Kiana Mohajeri, Maika Malig, et al.. (2014). PLoS ONE. Cited 41 times. https://doi.org/10.1371/journal.pone.0104396

Genome‐wide association and multi‐omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women

Jaeyoon Chung, Anjali Das, Xinyu Sun, et al.. (2022). Alzheimer's & Dementia. Cited 40 times. https://doi.org/10.1002/alz.12719

Are common disease susceptibility alleles the same in outbred and founder populations?

Dina L. Newman, S. Hoffjan, C. Bourgain, et al.. (2004). European Journal of Human Genetics. Cited 36 times. https://doi.org/10.1038/sj.ejhg.5201191

PRIMAL: Fast and Accurate Pedigree-based Imputation from Sequence Data in a Founder Population

Oren E. Livne, Lide Han, G. Alkorta-Aranburu, et al.. (2015). PLoS Computational Biology. Cited 32 times. https://doi.org/10.1371/journal.pcbi.1004139

The CFTR Met 470 Allele Is Associated with Lower Birth Rates in Fertile Men from a Population Isolate

Gülüm Kosova, Joseph K. Pickrell, Joanna L. Kelley, et al.. (2010). PLoS Genetics. Cited 25 times. https://doi.org/10.1371/journal.pgen.1000974

Accurate Imputation of Rare and Common Variants in a Founder Population From a Small Number of Sequenced Individuals

Lawrence H. Uricchio, Jessica X. Chong, Kevin D. Ross, et al.. (2012). Genetic Epidemiology. Cited 20 times. https://doi.org/10.1002/gepi.21623

Rare non-coding variants are associated with plasma lipid traits in a founder population

C. Igartua, S. Mozaffari, Dan L. Nicolae, et al.. (2017). Scientific Reports. Cited 19 times. https://doi.org/10.1038/s41598-017-16550-8

Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree

S. Mozaffari, J. DeCara, Sanjiv J. Shah, et al.. (2019). Communications Biology. Cited 19 times. https://doi.org/10.1038/s42003-018-0267-4

Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma

E. Thompson, Quynh Dang, B. Mitchell-Handley, et al.. (2020). Genome Medicine. Cited 19 times. https://doi.org/10.1186/s13073-020-00759-w

Integrated analyses of gene expression and genetic association studies in a founder population

D. Cusanovich, Minal Çalışkan, C. Billstrand, et al.. (2016). Human Molecular Genetics. Cited 16 times. https://doi.org/10.1093/hmg/ddw061

Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans

E. Thompson, Ying Sun, Dan L. Nicolae, et al.. (2010). Genetic Epidemiology. Cited 14 times. https://doi.org/10.1002/gepi.20442

Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies

Michelle M. Stein, C. Hrusch, A. Sperling, et al.. (2018). Genes & Immunity. Cited 12 times. https://doi.org/10.1038/s41435-018-0038-8

Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region

Selene M. Clay, Nathan Schoettler, A. Goldstein, et al.. (2022). Genome Medicine. Cited 12 times. https://doi.org/10.1186/s13073-022-01058-2

Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions

S. Mozaffari, Michelle M. Stein, K. Magnaye, et al.. (2018). PLoS ONE. Cited 7 times. https://doi.org/10.1371/journal.pone.0203906