NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)

Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems.

S. Redline, P. Tishler, M. Schluchter, et al.. (1999). American journal of respiratory and critical care medicine. Cited 1,215 times. https://doi.org/10.1164/AJRCCM.159.5.9809079

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

D. Swerdlow, M. Holmes, Karoline B. Kuchenbaecker, et al.. (2012). Lancet (London, England). Cited 993 times. https://doi.org/10.1016/S0140-6736(12)60110-X

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

D. Swerdlow, D. Preiss, Karoline B. Kuchenbaecker, et al.. (2015). Lancet. Cited 650 times. https://doi.org/10.1016/S0140-6736(14)61183-1

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Michael V. Holmes, C. Dale, L. Zuccolo, et al.. (2014). The BMJ. Cited 632 times. https://doi.org/10.1136/bmj.g4164

Racial differences in sleep-disordered breathing in African-Americans and Caucasians.

S. Redline, P. Tishler, M. Hans, et al.. (1997). American journal of respiratory and critical care medicine. Cited 613 times. https://doi.org/10.1164/AJRCCM.155.1.9001310

Sleep duration and biomarkers of inflammation.

Sanjay R. Patel, X. Zhu, A. Storfer‐Isser, et al.. (2009). Sleep. Cited 572 times. https://doi.org/10.1093/SLEEP/32.2.200

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Z. Dastani, M. Hivert, N. Timpson, et al.. (2012). PLoS Genetics. Cited 518 times. https://doi.org/10.1371/journal.pgen.1002607

Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing.

P. Tishler, E. Larkin, M. Schluchter, et al.. (2003). JAMA. Cited 517 times. https://doi.org/10.1001/JAMA.289.17.2230

Gender differences in sleep disordered breathing in a community-based sample.

S. Redline, K. Kump, P. Tishler, et al.. (1994). American journal of respiratory and critical care medicine. Cited 506 times. https://doi.org/10.1164/AJRCCM.149.3.8118642

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

B. Keating, Sam Tischfield, S. Murray, et al.. (2008). PLoS ONE. Cited 431 times. https://doi.org/10.1371/journal.pone.0003583

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension.

Xiaofeng Zhu, Tao Feng, Tao Feng, et al.. (2015). American journal of human genetics. Cited 367 times. https://doi.org/10.1016/j.ajhg.2014.11.011

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

G. Lettre, Cameron D. Palmer, Taylor R. Young, et al.. (2011). PLoS Genetics. Cited 335 times. https://doi.org/10.1371/journal.pgen.1001300

The landscape of recombination in African Americans

A. Hinch, Arti Tandon, N. Patterson, et al.. (2011). Nature. Cited 334 times. https://doi.org/10.1038/nature10336

The familial aggregation of obstructive sleep apnea.

S. Redline, P. Tishler, T. Tosteson, et al.. (1995). American journal of respiratory and critical care medicine. Cited 289 times. https://doi.org/10.1164/ajrccm.151.3.7881656

A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry

K. Monda, K. Monda, Gary K. Chen, et al.. (2013). Nature genetics. Cited 255 times. https://doi.org/10.1038/ng.2608

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

F. Asselbergs, Yiran Guo, Erik P A van Iperen, et al.. (2012). American journal of human genetics. Cited 248 times. https://doi.org/10.1016/j.ajhg.2012.08.032

A whole-genome scan for obstructive sleep apnea and obesity.

L. Palmer, Sarah G Buxbaum, E. Larkin, et al.. (2003). American journal of human genetics. Cited 225 times. https://doi.org/10.1086/346064

The relationship between craniofacial morphology and obstructive sleep apnea in whites and in African-Americans.

B. Çakirer, M. Hans, G. Graham, et al.. (2001). American journal of respiratory and critical care medicine. Cited 217 times. https://doi.org/10.1164/AJRCCM.163.4.2005136

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

E. Fox, J. H. Young, Yali Li, et al.. (2011). Human Molecular Genetics. Cited 189 times. https://doi.org/10.1093/hmg/ddr092

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

N. Franceschini, Ervin F. Fox, Zhaogong Zhang, et al.. (2013). American journal of human genetics. Cited 189 times. https://doi.org/10.1016/j.ajhg.2013.07.010

Whole genome scan for obstructive sleep apnea and obesity in African-American families.

L. Palmer, Sarah G Buxbaum, E. Larkin, et al.. (2004). American journal of respiratory and critical care medicine. Cited 165 times. https://doi.org/10.1164/RCCM.200304-493OC

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

V. Tragante, M. Barnes, S. Ganesh, et al.. (2014). American journal of human genetics. Cited 156 times. https://doi.org/10.1016/j.ajhg.2013.12.016

Candidate Gene Association Resource (CARe): Design, Methods, and Proof of Concept

K. Musunuru, G. Lettre, Taylor R. Young, et al.. (2010). Circulation: Cardiovascular Genetics. Cited 149 times. https://doi.org/10.1161/CIRCGENETICS.109.882696

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

S. Ganesh, V. Tragante, Wei Guo, et al.. (2013). Human molecular genetics. Cited 145 times. https://doi.org/10.1093/hmg/dds555

Genome-wide association analysis identifies six new loci associated with forced vital capacity

D. Loth, M. Artigas, S. Gharib, et al.. (2014). Nature Genetics. Cited 143 times. https://doi.org/10.1038/ng.3011

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

M. Lanktree, Yiran Guo, Muhammed Murtaza, et al.. (2011). American journal of human genetics. Cited 142 times. https://doi.org/10.1016/j.ajhg.2010.11.007

Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis

Sarah G Buxbaum, R. Elston, P. Tishler, et al.. (2002). Genetic Epidemiology. Cited 141 times. https://doi.org/10.1002/gepi.0170

Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

M. Sabater-Lleal, Jie Huang, D. Chasman, et al.. (2013). Circulation. Cited 141 times. https://doi.org/10.1161/CIRCULATIONAHA.113.002251

A candidate gene study of obstructive sleep apnea in European Americans and African Americans.

E. Larkin, Sanjay R. Patel, Robert J. Goodloe, et al.. (2010). American journal of respiratory and critical care medicine. Cited 121 times. https://doi.org/10.1164/rccm.201002-0192OC

Differences in polysomnography predictors for hypertension and impaired glucose tolerance.

Francisco Lopez-Jimenez, Viread K. Somers, Loreto Sulit, et al.. (2006). Sleep. Cited 120 times. https://doi.org/10.1093/SLEEP/29.6.777

Novel Loci Associated with Usual Sleep Duration: The CHARGE Consortium Genome-Wide Association Study

D. Gottlieb, K. Hek, Ting-hsu Chen, et al.. (2014). Molecular psychiatry. Cited 117 times. https://doi.org/10.1038/mp.2014.133

Predictors of longitudinal change in sleep-disordered breathing in a nonclinic population.

S. Redline, M. Schluchter, E. Larkin, et al.. (2003). Sleep. Cited 115 times. https://doi.org/10.1093/SLEEP/26.6.703

Genome-wide meta-analyses of smoking behaviors in African Americans

S. David, S. David, S. David, et al.. (2012). Translational Psychiatry. Cited 103 times. https://doi.org/10.1038/tp.2012.41

Soluble interleukin 6 receptor: A novel marker of moderate to severe sleep-related breathing disorder.

R. Mehra, A. Storfer‐Isser, H. Kirchner, et al.. (2006). Archives of internal medicine. Cited 98 times. https://doi.org/10.1001/ARCHINTE.166.16.1725

Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

A. N’Diaye, Gary K. Chen, Cameron D. Palmer, et al.. (2011). PLoS Genetics. Cited 98 times. https://doi.org/10.1371/journal.pgen.1002298

Obstructive sleep apnea is associated with increased urinary albumin excretion.

Michael D. Faulx, A. Storfer‐Isser, H. Kirchner, et al.. (2007). Sleep. Cited 96 times. https://doi.org/10.1093/SLEEP/30.7.923

Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

Yiran Guo, M. Lanktree, K. Taylor, et al.. (2013). Human molecular genetics. Cited 92 times. https://doi.org/10.1093/hmg/dds396

Ventilatory-control abnormalities in familial sleep apnea.

S. Redline, Janice Leitner, Jean L. Arnold, et al.. (1997). American journal of respiratory and critical care medicine. Cited 84 times. https://doi.org/10.1164/AJRCCM.156.1.9610016

Shared genetic basis for obstructive sleep apnea and adiposity measures

Sanjay R. Patel, E. Larkin, Susan Redline. (2008). International Journal of Obesity. Cited 84 times. https://doi.org/10.1038/sj.ijo.0803803

Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.

Xiaofeng Zhu, J. H. Young, Ervin F. Fox, et al.. (2011). Human molecular genetics. Cited 83 times. https://doi.org/10.1093/hmg/ddr113

The association of sudden unexpected infant death with obstructive sleep apnea.

P. Tishler, S. Redline, V. Ferrette, et al.. (1996). American journal of respiratory and critical care medicine. Cited 82 times. https://doi.org/10.1164/AJRCCM.153.6.8665046

Empirical evidence for "syndrome Z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures.

N. Nock, Li Li, E. Larkin, et al.. (2009). Sleep. Cited 78 times. https://doi.org/10.1093/SLEEP/32.5.615

Relationship between obstructive sleep apnea and diurnal leptin rhythms.

Sanjay R. Patel, L. Palmer, E. Larkin, et al.. (2004). Sleep. Cited 78 times. https://doi.org/10.1093/SLEEP/27.2.235

Association of Genetic Loci with Sleep Apnea in European Americans and African-Americans: The Candidate Gene Association Resource (CARe)

Sanjay R. Patel, Robert J. Goodloe, Gourab De, et al.. (2012). PLoS ONE. Cited 77 times. https://doi.org/10.1371/journal.pone.0048836

Correlations between cephalometric and facial photographic measurements of craniofacial form.

Xingzhong Zhang, Mark G. Hans, G. Graham, et al.. (2007). American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. Cited 75 times. https://doi.org/10.1016/J.AJODO.2005.02.033

Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak

E. Larkin, Sanjay R. Patel, S. Redline, et al.. (2006). Genetic Epidemiology. Cited 74 times. https://doi.org/10.1002/gepi.20127

Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland Family Study.

R. Mehra, Fang Xu, D. Babineau, et al.. (2010). American journal of respiratory and critical care medicine. Cited 63 times. https://doi.org/10.1164/rccm.201001-0020OC

APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema

K. M. Burkart, A. Manichaikul, J. Wilk, et al.. (2013). European Respiratory Journal. Cited 54 times. https://doi.org/10.1183/09031936.00147612

GEE‐Based SNP Set Association Test for Continuous and Discrete Traits in Family‐Based Association Studies

Xuefeng Wang, Seunggeun Lee, Xiaofeng Zhu, et al.. (2013). Genetic Epidemiology. Cited 53 times. https://doi.org/10.1002/gepi.21763

The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension.

Sanjay R. Patel, E. Larkin, E. Mignot, et al.. (2007). Sleep. Cited 52 times. https://doi.org/10.1093/SLEEP/30.4.531

Heritability of upper airway dimensions derived using acoustic pharyngometry

Sanjay R. Patel, Jennifer Frame, E. Larkin, et al.. (2008). European Respiratory Journal. Cited 51 times. https://doi.org/10.1183/09031936.00029808

Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project

K. Musunuru, Siôn Romaine, G. Lettre, et al.. (2012). PLoS ONE. Cited 51 times. https://doi.org/10.1371/journal.pone.0036473

Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations

Clara C Elbers, Yiran Guo, V. Tragante, et al.. (2012). PLoS ONE. Cited 51 times. https://doi.org/10.1371/journal.pone.0050198

Novel Loci Associated With PR Interval in a Genome-Wide Association Study of 10 African American Cohorts

Anne M. Butler, Xiaoyan Yin, Daniel S. Evans, et al.. (2012). Circulation: Cardiovascular Genetics. Cited 48 times. https://doi.org/10.1161/CIRCGENETICS.112.963991

Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans

J. Smith, C. Avery, Daniel S. Evans, et al.. (2012). Circulation: Cardiovascular Genetics. Cited 48 times. https://doi.org/10.1161/CIRCGENETICS.112.962787

Common variants in DRD2 are associated with sleep duration: the CARe consortium.

B. Cade, D. Gottlieb, D. Lauderdale, et al.. (2016). Human molecular genetics. Cited 48 times. https://doi.org/10.1093/hmg/ddv434

Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).

C. Wassel, L. Lange, B. Keating, et al.. (2011). Blood. Cited 43 times. https://doi.org/10.1182/blood-2010-06-289546

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium.

C. Wassel, C. Lamina, Vijay Nambi, et al.. (2012). Atherosclerosis. Cited 36 times. https://doi.org/10.1016/j.atherosclerosis.2012.01.039

Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans

Jaclyn W. Ellis, E. Lange, Jin Li, et al.. (2014). Human Genetics. Cited 36 times. https://doi.org/10.1007/s00439-014-1439-z

Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses

Jingjing Liang, B. Cade, Heming Wang, et al.. (2016). Genetic Epidemiology. Cited 33 times. https://doi.org/10.1002/gepi.21957

Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique.

Lamia H Ibrahim, F. Jacono, Sanjay R. Patel, et al.. (2010). Sleep. Cited 32 times. https://doi.org/10.1093/SLEEP/33.5.643

Entropy-Based Measures for Quantifying Sleep-Stage Transition Dynamics: Relationship to Sleep Fragmentation and Daytime Sleepiness

Matthew R. Kirsch, K. Monahan, Jia Weng, et al.. (2012). IEEE Transactions on Biomedical Engineering. Cited 32 times. https://doi.org/10.1109/TBME.2011.2179032

Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations.

Sachiko Yoneyama, Yiran Guo, M. Lanktree, et al.. (2014). Human molecular genetics. Cited 30 times. https://doi.org/10.1093/hmg/ddt626

Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants.

R. Deo, M. Nalls, C. Avery, et al.. (2013). Heart rhythm. Cited 29 times. https://doi.org/10.1016/j.hrthm.2012.11.014

Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts

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Relationship between 24-H blood pressure and sleep disordered breathing in a normotensive community sample.

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Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.

Heming Wang, B. Cade, Han Chen, et al.. (2016). Human molecular genetics. Cited 24 times. https://doi.org/10.1093/hmg/ddw324

Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects

Sampo Sammalisto, T. Hiekkalinna, K. Schwander, et al.. (2009). European Journal of Human Genetics. Cited 23 times. https://doi.org/10.1038/ejhg.2008.152

Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees.

J. Sul, B. Cade, M. Cho, et al.. (2016). American journal of human genetics. Cited 23 times. https://doi.org/10.1016/j.ajhg.2016.08.015

Using Linkage Analysis to Identify Quantitative Trait Loci for Sleep Apnea in Relationship to Body Mass Index

E. Larkin, Sanjay R. Patel, Robert C. Elston, et al.. (2008). Annals of Human Genetics. Cited 22 times. https://doi.org/10.1111/j.1469-1809.2008.00472.x

Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource

Ching-Ti Liu, M. Ng, D. Rybin, et al.. (2012). Diabetologia. Cited 22 times. https://doi.org/10.1007/s00125-012-2656-4

Oropharyngeal dimensions in adults: effect of ethnicity, gender, and sleep apnea.

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A measure of ventilatory variability at wake-sleep transition predicts sleep apnea severity.

Lamia H Ibrahim, Sanjay R. Patel, Mo H. Modarres, et al.. (2008). Chest. Cited 20 times. https://doi.org/10.1378/chest.07-1705

The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function

Ya-Juan Wang, B. Tayo, A. Bandyopadhyay, et al.. (2014). PLoS Genetics. Cited 18 times. https://doi.org/10.1371/journal.pgen.1004641

Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes

Archana Tare, J. Lane, B. Cade, et al.. (2014). Diabetologia. Cited 17 times. https://doi.org/10.1007/s00125-013-3110-y

Study of the relationship between the interleukin-6 gene and obstructive sleep apnea.

E. Larkin, Sanjay R. Patel, Xiaofeng Zhu, et al.. (2010). Clinical and translational science. Cited 16 times.

Entropy-based measures of EEG arousals as biomarkers for sleep dynamics: applications to hypertension.

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Autonomic Markers of Impaired Glucose Metabolism: Effects of Sleep-Disordered Breathing

Wenli Wang, S. Redline, M. Khoo. (2012). Journal of Diabetes Science and Technology. Cited 12 times. https://doi.org/10.1177/193229681200600521

Linkage of serum leptin levels in families with sleep apnea

E. Larkin, R. Elston, S. Patel, et al.. (2005). International Journal of Obesity. Cited 9 times. https://doi.org/10.1038/sj.ijo.0802872

A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups.

L. Weng, Weihong Tang, S. Rich, et al.. (2014). Thrombosis research. Cited 9 times. https://doi.org/10.1016/j.thromres.2014.05.018

Familial aggregation studies with matched proband sampling.

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A Semiparametric Method for Analyzing Matched Case–Control Family Studies with a Continuous Outcome and Proband Sampling

Molin Wang, J. Williamson, S. Redline. (2004). Biometrics. Cited 3 times. https://doi.org/10.1111/j.0006-341X.2004.00213.x