The Genetic Architecture of Smoking and Smoking Cessation

Functional impact of global rare copy number variation in autism spectrum disorders

D. Pinto, A. Pagnamenta, L. Klei, et al.. (2010). Nature. Cited 2,029 times. https://doi.org/10.1038/nature09146

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

S. Saccone, A. Hinrichs, N. Saccone, et al.. (2007). Human molecular genetics. Cited 881 times. https://doi.org/10.1093/HMG/DDL438

Novel genes identified in a high-density genome wide association study for nicotine dependence.

L. Bierut, P. Madden, N. Breslau, et al.. (2007). Human molecular genetics. Cited 657 times. https://doi.org/10.1093/HMG/DDL441

Variants in nicotinic receptors and risk for nicotine dependence.

L. Bierut, J. Stitzel, Jen C. Wang, et al.. (2008). The American journal of psychiatry. Cited 631 times. https://doi.org/10.1176/appi.ajp.2008.07111711

A genome-wide scan for common alleles affecting risk for autism

R. Anney, L. Klei, D. Pinto, et al.. (2010). Human Molecular Genetics. Cited 597 times. https://doi.org/10.1093/hmg/ddq307

Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence.

T. Baker, Megan E. Piper, Danielle E McCarthy, et al.. (2007). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 595 times. https://doi.org/10.1080/14622200701673480

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

C. Elks, J. Perry, P. Sulem, et al.. (2010). Nature Genetics. Cited 507 times. https://doi.org/10.1038/ng.714

A multiple motives approach to tobacco dependence: the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68).

Megan E. Piper, T. Piasecki, E. Federman, et al.. (2004). Journal of consulting and clinical psychology. Cited 485 times. https://doi.org/10.1037/0022-006X.72.2.139

Quality control and quality assurance in genotypic data for genome‐wide association studies

C. Laurie, K. Doheny, D. Mirel, et al.. (2010). Genetic Epidemiology. Cited 473 times. https://doi.org/10.1002/gepi.20516

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

N. Saccone, R. Culverhouse, Tae‐Hwi Schwantes‐An, et al.. (2010). PLoS Genetics. Cited 411 times. https://doi.org/10.1371/journal.pgen.1001053

Meta-analysis of genome-wide association studies for personality

M. D. Moor, P. Costa, A. Terracciano, et al.. (2012). Molecular Psychiatry. Cited 396 times. https://doi.org/10.1038/mp.2010.128

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction

R. Weiss, T. Baker, D. Cannon, et al.. (2008). PLoS Genetics. Cited 286 times. https://doi.org/10.1371/journal.pgen.1000125

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

N. Saccone, Jen C. Wang, N. Breslau, et al.. (2009). Cancer research. Cited 273 times. https://doi.org/10.1158/0008-5472.CAN-09-0786

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

N. Saccone, S. Saccone, A. Hinrichs, et al.. (2009). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Cited 238 times. https://doi.org/10.1002/ajmg.b.30828

A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies.

Megan E. Piper, Stevens S. Smith, Tanya R Schlam, et al.. (2009). Archives of general psychiatry. Cited 232 times. https://doi.org/10.1001/archgenpsychiatry.2009.142

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

Jen C. Wang, Carlos Cruchaga, N. Saccone, et al.. (2009). Human molecular genetics. Cited 211 times. https://doi.org/10.1093/hmg/ddp231

Nicotinic Receptor Gene Variants Influence Susceptibility to Heavy Smoking

V. Stevens, L. Bierut, Jeffrey T. Talbot, et al.. (2008). Cancer Epidemiology Biomarkers & Prevention. Cited 194 times. https://doi.org/10.1158/1055-9965.EPI-08-0585

Development of the Brief Wisconsin Inventory of Smoking Dependence Motives.

Stevens S. Smith, Megan E. Piper, D. Bolt, et al.. (2010). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 190 times. https://doi.org/10.1093/ntr/ntq032

Effects of smoking and smoking cessation on endothelial function: 1-year outcomes from a randomized clinical trial.

H. Johnson, L. Gossett, Megan E. Piper, et al.. (2010). Journal of the American College of Cardiology. Cited 189 times. https://doi.org/10.1016/j.jacc.2010.03.002

Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

H. Lester, C. Xiao, R. Srinivasan, et al.. (2009). The AAPS Journal. Cited 172 times. https://doi.org/10.1208/s12248-009-9090-7

The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions

M. Cornelis, A. Agrawal, J. Cole, et al.. (2010). Genetic Epidemiology. Cited 166 times. https://doi.org/10.1002/gepi.20492

Life before and after quitting smoking: an electronic diary study.

Danielle E McCarthy, T. Piasecki, M. Fiore, et al.. (2006). Journal of abnormal psychology. Cited 163 times. https://doi.org/10.1037/0021-843X.115.3.454

Psychiatric disorders in smokers seeking treatment for tobacco dependence: relations with tobacco dependence and cessation.

Megan E. Piper, Stevens S. Smith, Tanya R Schlam, et al.. (2010). Journal of consulting and clinical psychology. Cited 158 times. https://doi.org/10.1037/a0018065

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with ‘pleasurable buzz’ during early experimentation with smoking

Richard Sherva, K. Wilhelmsen, C. Pomerleau, et al.. (2008). Addiction (Abingdon, England). Cited 152 times. https://doi.org/10.1111/j.1360-0443.2008.02279.x

Assessing dimensions of nicotine dependence: an evaluation of the Nicotine Dependence Syndrome Scale (NDSS) and the Wisconsin Inventory of Smoking Dependence Motives (WISDM).

Megan E. Piper, Danielle E McCarthy, D. Bolt, et al.. (2008). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 147 times. https://doi.org/10.1080/14622200802097563

Comparative effectiveness of 5 smoking cessation pharmacotherapies in primary care clinics.

Stevens S. Smith, Danielle E McCarthy, S. Japuntich, et al.. (2009). Archives of internal medicine. Cited 139 times. https://doi.org/10.1001/archinternmed.2009.426

Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.

T. Baker, R. Weiss, D. Bolt, et al.. (2009). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 138 times. https://doi.org/10.1093/ntr/ntp064

Racial/Ethnic Disparities in the Use of Nicotine Replacement Therapy and Quit Ratios in Lifetime Smokers Ages 25 to 44 Years

S. Fu, M. Kodl, A. Joseph, et al.. (2008). Cancer Epidemiology Biomarkers & Prevention. Cited 135 times. https://doi.org/10.1158/1055-9965.EPI-07-2726

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.

L. Bierut. (2010). Trends in pharmacological sciences. Cited 118 times. https://doi.org/10.1016/j.tips.2009.10.004

Genome-wide association study of conduct disorder symptomatology

D. Dick, F. Aliev, R. Krueger, et al.. (2011). Molecular Psychiatry. Cited 114 times. https://doi.org/10.1038/mp.2010.73

Refining the tobacco dependence phenotype using the Wisconsin Inventory of Smoking Dependence Motives.

Megan E. Piper, D. Bolt, Su-Young Kim, et al.. (2008). Journal of abnormal psychology. Cited 114 times. https://doi.org/10.1037/a0013298

Smoking intensity and lipoprotein abnormalities in active smokers.

L. Gossett, H. Johnson, Megan E. Piper, et al.. (2009). Journal of clinical lipidology. Cited 112 times. https://doi.org/10.1016/j.jacl.2009.10.008

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans

N. Saccone, T.‐H. Schwantes‐An, J. C. Wang, et al.. (2010). Genes. Cited 108 times. https://doi.org/10.1111/j.1601-183X.2010.00608.x

Using mediational models to explore the nature of tobacco motivation and tobacco treatment effects.

Megan E. Piper, E. Federman, Danielle E McCarthy, et al.. (2006). Journal of abnormal psychology. Cited 102 times. https://doi.org/10.1037/0021-843X.117.1.94

Nicotine dependence and genetic variation in the nicotinic receptors.

L. Bierut. (2009). Drug and alcohol dependence. Cited 100 times. https://doi.org/10.1016/j.drugalcdep.2009.06.003

A New Statistic to Evaluate Imputation Reliability

Peng Lin, Sarah M. Hartz, Zhehao Zhang, et al.. (2010). PLoS ONE. Cited 97 times. https://doi.org/10.1371/journal.pone.0009697

Psychological mediators of bupropion sustained-release treatment for smoking cessation.

Danielle E McCarthy, T. Piasecki, Daniel L Lawrence, et al.. (2008). Addiction. Cited 97 times. https://doi.org/10.1111/j.1360-0443.2008.02275.x

A genome-wide association study of alcohol dependence

L. Bierut, A. Agrawal, K. Bucholz, et al.. (2010). Proceedings of the National Academy of Sciences. Cited 89 times. https://doi.org/10.1073/pnas.0911109107

Effects of smoking intensity and cessation on inflammatory markers in a large cohort of active smokers.

Asha Asthana, H. Johnson, Megan E. Piper, et al.. (2010). American heart journal. Cited 82 times. https://doi.org/10.1016/j.ahj.2010.06.006

A randomized controlled clinical trial of bupropion SR and individual smoking cessation counseling.

Danielle E McCarthy, T. Piasecki, Daniel L Lawrence, et al.. (2008). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 80 times. https://doi.org/10.1080/14622200801968343

Efficacy of bupropion alone and in combination with nicotine gum.

Megan E. Piper, E. Federman, Danielle E McCarthy, et al.. (2007). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 76 times. https://doi.org/10.1080/14622200701540820

Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence.

Li-Shiun Chen, Eric O. Johnson, N. Breslau, et al.. (2009). Addiction. Cited 72 times. https://doi.org/10.1111/J.1360-0443.2009.02697.X

Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence

S. Saccone, N. Saccone, G. Swan, et al.. (2008). Bioinformatics. Cited 70 times. https://doi.org/10.1093/bioinformatics/btn315

Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.

Eric O. Johnson, Li-Shiun Chen, N. Breslau, et al.. (2010). Addiction. Cited 66 times. https://doi.org/10.1111/j.1360-0443.2010.03074.x

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5′ upstream polymorphisms

Ryan M. Smith, Houda Alachkar, A. Papp, et al.. (2011). European Journal of Human Genetics. Cited 65 times. https://doi.org/10.1038/ejhg.2010.120

Disruption at the PTCHD1 Locus on Xp22.11 in Autism Spectrum Disorder and Intellectual Disability

A. Noor, Annabel Whibley, C. Marshall, et al.. (2010). Science Translational Medicine. Cited 64 times. https://doi.org/10.1126/scitranslmed.3001267

Race differences in nicotine dependence in the Collaborative Genetic study of Nicotine Dependence (COGEND).

Zhehui Luo, G. F. Alvarado, D. Hatsukami, et al.. (2008). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 59 times. https://doi.org/10.1080/14622200802163266

Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study.

A. Agrawal, M. Pergadia, S. Saccone, et al.. (2008). Addiction. Cited 53 times. https://doi.org/10.1111/j.1360-0443.2008.02236.x

The Wisconsin Predicting Patients' Relapse questionnaire.

D. Bolt, Megan E. Piper, Danielle E McCarthy, et al.. (2009). Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Cited 52 times. https://doi.org/10.1093/ntr/ntp030

Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.

Richard Sherva, J. Rice, R. Neuman, et al.. (2009). Alcoholism, clinical and experimental research. Cited 50 times. https://doi.org/10.1111/j.1530-0277.2009.00904.x

Using Decision Tree Analysis to Identify Risk Factors for Relapse to Smoking

Megan E. Piper, Wei-Yin Loh, Stevens S. Smith, et al.. (2011). Substance Use & Misuse. Cited 50 times. https://doi.org/10.3109/10826081003682222

Analysis of [3',3'-d(2)]-nicotine and [3',3'-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry.

S. Murphy, P. Villalta, S. Ho, et al.. (2007). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. Cited 48 times. https://doi.org/10.1016/J.JCHROMB.2007.06.018

Association of CHRN genes with “dizziness” to tobacco

M. Ehringer, M. McQueen, Nicole R. Hoft, et al.. (2010). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Cited 46 times. https://doi.org/10.1002/ajmg.b.31027

GENETIC STUDY: FULL ARTICLE: Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes

R. Grucza, E. Johnson, R. Krueger, et al.. (2010). Addiction Biology. Cited 42 times. https://doi.org/10.1111/j.1369-1600.2010.00220.x

Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.

Min Wang, H. Vikis, Yian Wang, et al.. (2007). Cancer research. Cited 40 times. https://doi.org/10.1158/0008-5472.can-06-2723

In search of causal variants: refining disease association signals using cross-population contrasts

N. Saccone, S. Saccone, A. Goate, et al.. (2008). BMC Genetics. Cited 36 times. https://doi.org/10.1186/1471-2156-9-58

Supplementing High-Density SNP Microarrays for Additional Coverage of Disease-Related Genes: Addiction as a Paradigm

S. Saccone, L. Bierut, E. Chesler, et al.. (2009). PLoS ONE. Cited 30 times. https://doi.org/10.1371/journal.pone.0005225

Genetic variation that contributes to nicotine dependence.

L. Bierut. (2007). Pharmacogenomics. Cited 27 times. https://doi.org/10.2217/14622416.8.8.881

Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity

J. Wilking, Kirstin G. Hesterberg, E. Crouch, et al.. (2010). Pharmacogenetics and Genomics. Cited 24 times. https://doi.org/10.1097/FPC.0b013e3283369347

Risk factors for subclinical carotid atherosclerosis among current smokers.

H. Johnson, Megan E. Piper, D. Jorenby, et al.. (2010). Preventive cardiology. Cited 23 times. https://doi.org/10.1111/j.1751-7141.2010.00068.x

Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.

A. Agrawal, M. Pergadia, S. Balasubramanian, et al.. (2009). Addiction. Cited 22 times. https://doi.org/10.1111/j.1360-0443.2008.02445.x

Test of measurement invariance of the FTND across demographic groups: assessment, effect size, and prediction of cessation.

Eric O. Johnson, A. Morgan-Lopez, N. Breslau, et al.. (2008). Drug and alcohol dependence. Cited 22 times. https://doi.org/10.1016/J.DRUGALCDEP.2007.10.001

Do smokers know what we're talking about? The construct validity of nicotine dependence questionnaire measures.

S. Japuntich, Megan E. Piper, Tanya R Schlam, et al.. (2009). Psychological assessment. Cited 19 times. https://doi.org/10.1037/a0017312

A Testable Prognostic Model of Nicotine Dependence

R. Ramoni, N. Saccone, D. Hatsukami, et al.. (2009). Journal of Neurogenetics. Cited 13 times. https://doi.org/10.1080/01677060802572911

Variants Weakly Correlated with CHRNA5 D398N Polymorphism Should be Considered in Transcriptional Deregulation at the 15q25 Locus Associated with Lung Cancer Risk

Jen C. Wang, L. Bierut, A. Goate. (2009). Clinical Cancer Research. Cited 10 times. https://doi.org/10.1158/1078-0432.CCR-09-1108

Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence

R. Culverhouse, N. Saccone, J. Stitzel, et al.. (2011). Human Genetics. Cited 8 times. https://doi.org/10.1007/s00439-010-0911-7

A Comparison of Association Statistics between Pooled and Individual Genotypes

J. Knight, S. Saccone, Zhehao Zhang, et al.. (2009). Human Heredity. Cited 6 times. https://doi.org/10.1159/000194975