NHLBI and NIA The New England Centenarian Study (NECS)

Morbidity profiles of centenarians: survivors, delayers, and escapers.

Jessica Evert, Elizabeth V. Lawler, Hazel Bogan, et al.. (2003). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 475 times. https://doi.org/10.1093/GERONA/58.3.M232

Life-long sustained mortality advantage of siblings of centenarians

T. Perls, J. Wilmoth, Robin Levenson, et al.. (2002). Proceedings of the National Academy of Sciences of the United States of America. Cited 372 times. https://doi.org/10.1073/pnas.122587599

The oldest old.

Thomas T Perls. (1995). Scientific American. Cited 336 times. https://doi.org/10.1038/SCIENTIFICAMERICAN0195-70

Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span.

S. Andersen, P. Sebastiani, D. Dworkis, et al.. (2012). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 332 times. https://doi.org/10.1093/gerona/glr223

A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4

A. Puca, M. Daly, S. Brewster, et al.. (2001). Proceedings of the National Academy of Sciences of the United States of America. Cited 310 times. https://doi.org/10.1073/pnas.181337598

Centenarians: the older you get, the healthier you have been

Rachel A. Hitt, Y. Young-Xu, M. Silver, et al.. (1999). The Lancet. Cited 275 times. https://doi.org/10.1016/S0140-6736(99)01987-X

Middle-aged mothers live longer

T. Perls, L. Alpert, R. Fretts. (1997). Nature. Cited 230 times. https://doi.org/10.1038/38148

Imputation of missing genotypes: an empirical evaluation of IMPUTE

Zhenming Zhao, Nadia Timofeev, Stephen W. Hartley, et al.. (2008). BMC Genetics. Cited 208 times. https://doi.org/10.1186/1471-2156-9-85

Siblings of centenarians live longer

T. Perls, E. Bubrick, C. Wager, et al.. (1998). The Lancet. Cited 184 times. https://doi.org/10.1016/S0140-6736(05)61126-9

Lower All‐Cause, Cardiovascular, and Cancer Mortality in Centenarians' Offspring

Dellara F. Terry, Marsha A. Wilcox, M. McCormick, et al.. (2004). Journal of the American Geriatrics Society. Cited 159 times. https://doi.org/10.1111/j.1532-5415.2004.52561.x

Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

Bard J. Geesaman, Erica K. Benson, S. Brewster, et al.. (2003). Proceedings of the National Academy of Sciences of the United States of America. Cited 155 times. https://doi.org/10.1073/pnas.1936249100

Disentangling the roles of disability and morbidity in survival to exceptional old age.

Dellara F. Terry, P. Sebastiani, S. Andersen, et al.. (2008). Archives of internal medicine. Cited 141 times. https://doi.org/10.1001/archinternmed.2007.75

A family longevity selection score: ranking sibships by their longevity, size, and availability for study.

P. Sebastiani, E. Hadley, M. Province, et al.. (2009). American journal of epidemiology. Cited 130 times. https://doi.org/10.1093/aje/kwp309

Exceptional Familial Clustering for Extreme Longevity in Humans

T. Perls, Maureen Shea-Drinkwater, Jennifer Bowen-Flynn, et al.. (2000). Journal of the American Geriatrics Society. Cited 120 times. https://doi.org/10.1111/jgs.2000.48.11.1483

Understanding the Determinants of Exceptional Longevity

T. Perls, Dellara F. Terry. (2003). Annals of Internal Medicine. Cited 114 times. https://doi.org/10.7326/0003-4819-139-5_Part_2-200309021-00013

RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

P. Sebastiani, M. Montano, A. Puca, et al.. (2009). PLoS ONE. Cited 108 times. https://doi.org/10.1371/journal.pone.0008210

The genetics of exceptional human longevity

T. Perls, L. Kunkel, A. Puca. (2002). Journal of Molecular Neuroscience. Cited 103 times. https://doi.org/10.1007/s12031-002-0039-x

The Relationship between Age, Gender and Cognitive Performance in the Very Old: The Effect of Selective Survival

T. Perls, John N. Morris, W. L. Ooi, et al.. (1993). Journal of the American Geriatrics Society. Cited 102 times. https://doi.org/10.1111/j.1532-5415.1993.tb07302.x

Validity of reported age and centenarian prevalence in New England.

Thomas T Perls, K. Bochen, M. Freeman, et al.. (1999). Age and ageing. Cited 96 times. https://doi.org/10.1093/AGEING/28.2.193

Cardiovascular disease delay in centenarian offspring.

Dellara F. Terry, M. Wilcox, M. McCormick, et al.. (2004). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 93 times. https://doi.org/10.1093/GERONA/59.4.M385

Association of longer telomeres with better health in centenarians.

Dellara F. Terry, V. Nolan, S. Andersen, et al.. (2008). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 91 times. https://doi.org/10.1093/GERONA/63.8.809

Centenarian Offspring: Start Healthier and Stay Healthier

Emily R. Adams, V. Nolan, S. Andersen, et al.. (2008). Journal of the American Geriatrics Society. Cited 82 times. https://doi.org/10.1111/j.1532-5415.2008.01949.x

The Genetics of Exceptional Human Longevity

T. Perls, L. Kunkel, A. Puca. (2002). Journal of the American Geriatrics Society. Cited 79 times. https://doi.org/10.1046/j.1532-5415.2002.49283.x

Genetics of exceptional longevity

T. Perls, Dellara F. Terry. (2003). Experimental Gerontology. Cited 77 times. https://doi.org/10.1016/S0531-5565(03)00098-6

Genome‐wide association studies and the genetic dissection of complex traits

P. Sebastiani, Nadia Timofeev, D. Dworkis, et al.. (2009). American Journal of Hematology. Cited 76 times. https://doi.org/10.1002/ajh.21440

Characteristics of 32 Supercentenarians

Emily A. Schoenhofen, D. Wyszynski, S. Andersen, et al.. (2006). Journal of the American Geriatrics Society. Cited 70 times. https://doi.org/10.1111/j.1532-5415.2006.00826.x

Dementia-free centenarians

T. Perls. (2004). Experimental Gerontology. Cited 64 times. https://doi.org/10.1016/j.exger.2004.08.015

Cardiovascular Disease Delay in Centenarian Offspring: Role of Heat Shock Proteins

Dellara F. Terry, M. McCormick, S. Andersen, et al.. (2004). Annals of the New York Academy of Sciences. Cited 63 times. https://doi.org/10.1196/annals.1297.092

Survival of parents and siblings of supercentenarians.

T. Perls, I. Kohler, S. Andersen, et al.. (2007). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 62 times. https://doi.org/10.1093/GERONA/62.9.1028

Whole Genome Sequences of a Male and Female Supercentenarian, Ages Greater than 114 Years

P. Sebastiani, A. Riva, M. Montano, et al.. (2012). Frontiers in Genetics. Cited 61 times. https://doi.org/10.3389/fgene.2011.00090

What does it take to live to 100?

T. Perls, Robin Levenson, M. Regan, et al.. (2002). Mechanisms of Ageing and Development. Cited 58 times. https://doi.org/10.1016/S0047-6374(01)00348-7

Centenarians who avoid dementia

T. Perls. (2004). Trends in Neurosciences. Cited 57 times. https://doi.org/10.1016/j.tins.2004.07.012

The different paths to 100.

T. Perls. (2006). The American journal of clinical nutrition. Cited 55 times. https://doi.org/10.1093/AJCN/83.2.484S

Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals.

G. Rebeck, T. Perls, H. West, et al.. (1994). Neurology. Cited 54 times.

First autopsy study of an Okinawan centenarian: absence of many age-related diseases.

A. Bernstein, B. Willcox, H. Tamaki, et al.. (2004). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 45 times. https://doi.org/10.1093/GERONA/59.11.1195

Human longevity and common variations in the LMNA gene: a meta‐analysis

K. Conneely, Brian C. Capell, M. Erdos, et al.. (2012). Aging Cell. Cited 44 times. https://doi.org/10.1111/j.1474-9726.2012.00808.x

Clustering by genetic ancestry using genome-wide SNP data

N. Solovieff, Stephen W. Hartley, C. Baldwin, et al.. (2010). BMC Genetics. Cited 44 times. https://doi.org/10.1186/1471-2156-11-108

Personality Traits of Centenarians' Offspring

J. Givens, Maureen T. Frederick, Leanne Silverman, et al.. (2009). Journal of the American Geriatrics Society. Cited 41 times. https://doi.org/10.1111/j.1532-5415.2009.02189.x

Cancer in the oldest old

S. Andersen, Dellara F. Terry, M. Wilcox, et al.. (2005). Mechanisms of Ageing and Development. Cited 40 times. https://doi.org/10.1016/j.mad.2004.08.019

Genetic and Environmental Influences on Exceptional Longevity and the AGE Nomogram

T. Perls. (2002). Annals of the New York Academy of Sciences. Cited 39 times. https://doi.org/10.1111/j.1749-6632.2002.tb02077.x

The genetics of aging.

T. Perls, L. Kunkel, A. Puca. (2002). Current opinion in genetics & development. Cited 29 times. https://doi.org/10.1016/S0959-437X(02)00310-6

Genetic and phenotypic markers among centenarians.

T. Perls. (2001). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 19 times.

BRCA1 Gene Sequence Variation in Centenarians

J. Vijg, T. Perls, C. Franceschi, et al.. (2001). Annals of the New York Academy of Sciences. Cited 16 times. https://doi.org/10.1111/j.1749-6632.2001.tb05639.x

A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples

P. Sebastiani, Zhenming Zhao, María M. Abad-Grau, et al.. (2008). BMC Genetics. Cited 13 times. https://doi.org/10.1186/1471-2156-9-6

Genetic Signatures of Exceptional Longevity in Humans

Paola Sebastiani, Nadia Solovieff, Andrew T. DeWan, et al.. (2012). PLoS ONE. Cited 12 times. https://doi.org/10.1371/journal.pone.0029848

The genetics of aging-- implications for pharmacogenomics.

T. Perls, A. Puca. (2002). Pharmacogenomics. Cited 12 times. https://doi.org/10.1517/14622416.3.4.469

The Different Paths to Age One Hundred

T. Perls. (2005). Annals of the New York Academy of Sciences. Cited 8 times. https://doi.org/10.1196/annals.1323.004

Apolipoprotein E and its association with Alzheimer's disease.

T. Perls. (1996). Journal of insurance medicine.