<p>Current findings of the genetic risk of schizophrenia and bipolar disorder emerging from genome wide association studies (GWAS) support a highly polygenic model displaying the full spectrum of causal alleles that includes the extremes of rare, penetrant alleles as well as common alleles of small effect. Lower frequency polymorphism, rare variants and private mutations have eluded measurement by GWAS studies and thus association with disease. In order to create a comprehensive catalogue of low frequency or rare coding variation in individuals with psychiatric disease and to build a foundation for future genetic studies of schizophrenia and bipolar disorder, we have obtained whole exome DNA sequence from a population-based schizophrenia and bipolar disorder Swedish case-control cohort.</p>

Sweden-Schizophrenia Population-Based Case-Control Exome Sequencing

A polygenic burden of rare disruptive mutations in schizophrenia

Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth.

Exome sequencing and the genetic basis of complex traits

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies

Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.