<p>We used massively parallel, paired-end sequencing of expressed transcripts (RNA-seq) to detect novel gene fusions in short-term cultures of glioma stem-like cells freshly isolated from nine patients carrying primary glioblastoma multiforme (GBM). The culture of primary GBM tumors under serum-free conditions selects cells that retain phenotypes and genotypes closely mirroring primary tumor profiles as compared to serum-cultured glioma cell lines that have largely lost their developmental identities.</p>

Gene Fusion Discovery through RNA Sequencing of Human Glioblastoma Stem    Cell Lines

Glioblastoma study with RNA-Seq data on dbGaP (24 participants)

Gene Fusion Discovery through RNA Sequencing of Human Glioblastoma Stem Cell Lines

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