The Longevity Genes Project

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Y. Suh, G. Atzmon, Miook Cho, et al.. (2008). Proceedings of the National Academy of Sciences. Cited 725 times. https://doi.org/10.1073/pnas.0705467105

Unique lipoprotein phenotype and genotype associated with exceptional longevity.

N. Barzilai, G. Atzmon, C. Schechter, et al.. (2003). JAMA. Cited 588 times. https://doi.org/10.1001/JAMA.290.15.2030

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

L. Pawlikowska, D. Hu, S. Huntsman, et al.. (2009). Aging Cell. Cited 351 times. https://doi.org/10.1111/j.1474-9726.2009.00493.x

Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity

D. Arking, G. Atzmon, A. Arking, et al.. (2005). Circulation Research. Cited 287 times. https://doi.org/10.1161/01.RES.0000157171.04054.30

Extreme longevity is associated with increased serum thyrotropin.

G. Atzmon, N. Barzilai, J. Hollowell, et al.. (2009). The Journal of clinical endocrinology and metabolism. Cited 255 times. https://doi.org/10.1210/jc.2008-2325

Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

G. Atzmon, Miook Cho, R. Cawthon, et al.. (2009). Proceedings of the National Academy of Sciences. Cited 254 times. https://doi.org/10.1073/pnas.0906191106

Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans

G. Atzmon, Marielisa Rincon, C. Schechter, et al.. (2006). PLoS Biology. Cited 214 times. https://doi.org/10.1371/journal.pbio.0040113

Clinical Phenotype of Families with Longevity

G. Atzmon, C. Schechter, W. Greiner, et al.. (2004). Journal of the American Geriatrics Society. Cited 189 times. https://doi.org/10.1111/j.1532-5415.2004.52068.x

Plasma HDL levels highly correlate with cognitive function in exceptional longevity.

G. Atzmon, I. Gabriely, W. Greiner, et al.. (2002). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 162 times. https://doi.org/10.1093/GERONA/57.11.M712

Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.

G. Atzmon, N. Barzilai, M. Surks, et al.. (2009). The Journal of clinical endocrinology and metabolism. Cited 160 times. https://doi.org/10.1210/jc.2009-0808

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

E. Kenny, I. Pe’er, A. Karban, et al.. (2012). PLoS Genetics. Cited 157 times. https://doi.org/10.1371/journal.pgen.1002559

Adiponectin levels and genotype: a potential regulator of life span in humans.

G. Atzmon, T. Pollin, J. Crandall, et al.. (2008). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 148 times. https://doi.org/10.1093/GERONA/63.5.447

Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging

A. Bergman, G. Atzmon, Kenny Q. Ye, et al.. (2007). PLoS Computational Biology. Cited 118 times. https://doi.org/10.1371/JOURNAL.PCBI.0030170

Lifestyle Factors of People with Exceptional Longevity

Swapnil N. Rajpathak, Yingheng Liu, O. Ben-David, et al.. (2011). Journal of the American Geriatrics Society. Cited 114 times. https://doi.org/10.1111/j.1532-5415.2011.03498.x

RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

P. Sebastiani, M. Montano, A. Puca, et al.. (2009). PLoS ONE. Cited 108 times. https://doi.org/10.1371/journal.pone.0008210

Biological evidence for inheritance of exceptional longevity

G. Atzmon, Marielisa Rincon, Pegah Rabizadeh, et al.. (2005). Mechanisms of Ageing and Development. Cited 107 times. https://doi.org/10.1016/j.mad.2004.08.026

A genotype of exceptional longevity is associated with preservation of cognitive function

N. Barzilai, G. Atzmon, C. Derby, et al.. (2006). Neurology. Cited 106 times. https://doi.org/10.1212/01.wnl.0000249116.50854.65

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing

S. Gombar, H. Jung, F. Dong, et al.. (2012). BMC Genomics. Cited 72 times. https://doi.org/10.1186/1471-2164-13-353

Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in an Ashkenazi Jewish Population

R. Neuman, J. Wasson, G. Atzmon, et al.. (2010). PLoS ONE. Cited 68 times. https://doi.org/10.1371/journal.pone.0009903

Genetic studies reveal the role of the endocrine and metabolic systems in aging.

N. Barzilai, I. Gabriely, G. Atzmon, et al.. (2010). The Journal of clinical endocrinology and metabolism. Cited 67 times. https://doi.org/10.1210/jc.2010-0859

Serum heat shock protein 70 level as a biomarker of exceptional longevity

Dellara F. Terry, D. Wyszynski, V. Nolan, et al.. (2006). Mechanisms of Ageing and Development. Cited 63 times. https://doi.org/10.1016/j.mad.2006.08.007

Exceptional longevity is associated with decreased reproduction

V. Tabatabaie, G. Atzmon, S. Rajpathak, et al.. (2011). Aging (Albany NY). Cited 59 times. https://doi.org/10.18632/AGING.100415

Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults

J. Walston, Amy M. Matteini, C. Nievergelt, et al.. (2009). Experimental Gerontology. Cited 54 times. https://doi.org/10.1016/j.exger.2009.02.004

Human longevity and common variations in the LMNA gene: a meta‐analysis

K. Conneely, Brian C. Capell, M. Erdos, et al.. (2012). Aging Cell. Cited 44 times. https://doi.org/10.1111/j.1474-9726.2012.00808.x

Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease

Guiqing Cai, G. Atzmon, A. Naj, et al.. (2012). Neurobiology of Aging. Cited 32 times. https://doi.org/10.1016/j.neurobiolaging.2010.03.003

Positive attitude towards life and emotional expression as personality phenotypes for centenarians

Kaori Kato, R. Zweig, N. Barzilai, et al.. (2012). Aging (Albany NY). Cited 30 times. https://doi.org/10.18632/AGING.100456

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.

D. Huffman, J. Deelen, Kenny Q. Ye, et al.. (2012). The journals of gerontology. Series A, Biological sciences and medical sciences. Cited 28 times. https://doi.org/10.1093/gerona/gls103

Ashkenazi Jewish Centenarians Do Not Demonstrate Enrichment in Mitochondrial Haplogroup J

L. Shlush, G. Atzmon, R. Weisshof, et al.. (2008). PLoS ONE. Cited 20 times. https://doi.org/10.1371/journal.pone.0003425

Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.

Nahoko Iwata, Jin Zhang, G. Atzmon, et al.. (2007). Mitochondrion. Cited 17 times. https://doi.org/10.1016/J.MITO.2007.03.001

Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension.

C. Schechter, N. Barzilai, J. Crandall, et al.. (2010). Mayo Clinic proceedings. Cited 16 times. https://doi.org/10.4065/mcp.2009.0594

Family History of Exceptional Longevity Is Associated with Lower Serum Uric Acid Levels in Ashkenazi Jews

J. Lai, G. Atzmon, M. Melamed, et al.. (2012). Journal of the American Geriatrics Society. Cited 11 times. https://doi.org/10.1111/j.1532-5415.2012.03902.x

Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA).

J. Wan, G. Atzmon, David Hwang, et al.. (2013). The Journal of clinical endocrinology and metabolism. Cited 7 times. https://doi.org/10.1210/jc.2012-2375