CIP: Differential Response to Hydroxyurea and Incidence of Stroke in Sickle Cell Disease
Biomarkers (6)
- BL F/F+S - Baseline fetal hemoglobin (HbF) before starting hydroxyurea (%HbF/%HbF+ %HbS)*100 (phv00196904.v2.p1)
- BL F/F+S - Baseline fetal hemoglobin (HbF) before starting hydroxyurea (%HbF/%HbF+ %HbS)*100 (phv00196904.v2.p1)
- DELTA HbF - (MTD F/F+S)-(BL F/F+S), where MTD F/F+S = Fetal hemoglobin (HbF) at the maximum hydroxyurea dose and BL F/F+S = Baseline fetal hemoglobin (HbF) before starting hydroxyurea (%HbF/%HbF+ %HbS)*100. (phv00196906.v2.p1)
- DELTA HbF - (MTD F/F+S)-(BL F/F+S), where MTD F/F+S = Fetal hemoglobin (HbF) at the maximum hydroxyurea dose and BL F/F+S = Baseline fetal hemoglobin (HbF) before starting hydroxyurea (%HbF/%HbF+ %HbS)*100. (phv00196906.v2.p1)
- MTD F/F+S - Fetal hemoglobin (HbF) at the maximum hydroxyurea dose (phv00196905.v2.p1)
- MTD F/F+S - Fetal hemoglobin (HbF) at the maximum hydroxyurea dose (phv00196905.v2.p1)
Demographics (4)
- SEX - Gender of participant (phv00196901.v2.p1)
- SEX - Gender of participant (phv00196901.v2.p1)
- START_AGE - Age they initiated the drug, hydroxyurea, in years (phv00196902.v2.p1)
- START_AGE - Age they initiated the drug, hydroxyurea, in years (phv00196902.v2.p1)
Disease Events (1)
- AFFECTION_STATUS - Case control status of the subject (phv00196895.v2.p1)
Other (16)
- ANALYTE_TYPE - Analyte Type (phv00196909.v2.p1)
- BODY_SITE - Body site where sample was collected (phv00196908.v2.p1)
- CONSENT - Consent group as determined by DAC (phv00196892.v2.p1)
- HU mg/kg - Maximum tolerated daily dose of hydroxyurea in milligrams per kilogram (phv00196903.v1.p1)
- HU mg/kg - Maximum tolerated daily dose of hydroxyurea in milligrams per kilogram (phv00196903.v2.p1)
- SAMP_SOURCE - Source repository where samples originate. HUSTLE=Long Term Effects of Hydroxyurea Therapy in Children with Sickle Cell Disease; SWITCH=Stroke with Transfusions Changing to Hydroxyurea (phv00196898.v2.p1)
- SAMPID - Sample ID (phv00196897.v2.p1)
- SAMPID - De-identified Sample ID (phv00196907.v2.p1)
- SAMPLE_USE - Sample Use (phv00200359.v2.p1)
- SOURCE_SAMPID - Sample ID used in the Source Repository. HUSTLE=Long Term Effects of Hydroxyurea Therapy in Children with Sickle Cell Disease; SWITCH=Stroke with Transfusions Changing to Hydroxyurea (phv00196899.v2.p1)
- SOURCE_SUBJID - Subject ID used in the Source Repository (phv00196894.v2.p1)
- SUBJ_SOURCE - Source repository where subjects originate (phv00196893.v2.p1)
- SUBJID - De-identified Subject ID (phv00196900.v1.p1)
- SUBJID - De-identified Subject ID (phv00196900.v2.p1)
- SUBJID - Subject ID (phv00196891.v2.p1)
- SUBJID - Subject ID (phv00196896.v2.p1)