For the NIH Roadmap Epigenomics project, we applied ChlP-Seq, HTBS and WGBS pipelines to generate comprehensive high-resolution maps of chromatin state and DNA methylation for 100 diverse cell types. Cell types were selected for their biological and medical importance, and for their potential to maximize the comprehensiveness of acquired epigenomic data. They include human ES cells, ES-derived cells, mesenchymal stem cells, reprogrammed stem cells and primary tissues. Comprehensive characterization of epigenetic marks ("the epigenome") is a critical step towards a global understanding of the human genome in health and disease. In this study we provide unprecedented views of the human epigenetic landscape and its variation across cell states, which offer fundamental insight into the functions and interrelationships of epigenetic marks, and provide a framework for future studies of normal and diseased epigenomes. The Roadmap Epigenomics Broad cohort is utilized in the following dbGaP sub-study. To view molecular data and derived variables collected in this sub-study, please click on the following sub-study below or in the "Sub-studies" box located on the right hand side of this top-level study page <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000700">phs000700</a> the Roadmap Epigenomics Broad cohort. <ul> <li><a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000610">phs000610</a> RM_Epigenomics_Broad_Alz</li> </ul>

RoadmapEpigenomics_Broad

The NIH Roadmap Epigenomics Mapping Consortium

Charting a dynamic DNA methylation landscape of the human genome

Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues

Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells

An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.