<p>The OPPERA project has two sub-studies investigating effects of genetic, physiological, psychological and clinical factors on the risk of developing painful temporomandibular disorder (TMD).</p> <ol> <li>OPPERA I baseline case-control study of chronic TMJD (dbGaP study accession <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000762">phs000762</a>). This sub-study uses a case-control study design to investigate characteristics associated with chronic TMD. The parent OPPERA phenotype file contains an indicator variable (<a>PHASE1CASECONTROL</a>) identifying participants in this sub-study. Data users should use the relevant case-classification variable (<a>CHRNONICTMDCASE</a>) and apply statistical methods appropriate for case-control studies when analyzing TMJD in this sub-study.</li> <li>OPPERA I prospective cohort for first onset of TMJD (dbGaP study accession <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000850">phs000850</a>). This sub-study uses a prospective cohort study design to investigate characteristics that predict risk of developing first-onset TMD. The parent OPPERA phenotype file contains an indicator variable (<a>PROSPECTIVECOHORT</a>) identifying participants in this sub-study. Data users should use the relevant case-classification variable (<a>INCIDENTCASE</a>) and the relevant time-in-study variable (<a>FOLLOWUPYEARS</a>) when analyzing TMJD in this sub-study. It is recommended that data users apply statistical methods appropriate for cohort studies of a dynamic population (for example, Cox regression models, where <a>INCIDENTCASE</a> is the censoring variable and <a>FOLLOWUPYEARS</a> is time in study). </li> </ol>

Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA)

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