<p>We profiled the methylation landscape of ~2100 DNA samples (~1100 cases of colorectal cancer and ~1000 controls) from the Ontario Familial Colon Cancer Registry (OFCCR) using the HumanMethylation450 array from Illumina. DNA was extracted from lymphocyte pellets, except for 99 samples for which DNA was extracted from lymphoblastoid cell lines. Samples were genotyped on the Affymetrix Human Mapping 100k and 500k arrays. The aim the study was to evaluate the interplay between genetic variation and methylation, including long-range epigenetic regulation.</p>

OFCCR SNP-CpG

Colorectal Neoplasms study with Methylation (CpG), SNP Genotypes (Array) data on dbGaP (2,402 participants)

OFCCR SNP-CpG

Description

Applying For Access

Summary