<p>The Exome Sequencing Analysis of Cutaneous Squamous Cell Carcinoma (SCC) study is a single-center cohort study. To identify recurrent genomic aberrations that might underlie the development of this malignancy, we performed whole exome sequencing on a series of SCC-normal pairs to distill a list of 336 candidate genes that were subsequently re-sequenced in 100 SCC-normal pairs with an average depth >1200X. This study also included whole-genome copy number analysis on 5 primary SCC with KNSTRN p.Ser24Phe and 5 histologically matched SCC with wild-type KNSTRN.</p>

Sequencing Analysis of Cutaneous Squamous Cell Carcinoma

1 selected publication including "Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous ..." (131 citations)

Sequencing Analysis of Cutaneous Squamous Cell Carcinoma

Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma