<p>Malignant peripheral nerve sheath tumors (MPNSTs) are a group of highly aggressive soft tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1-associated), or after radiotherapy (RT-associated). We utilized comprehensive genomic approaches and identified recurrent loss-of-function somatic alterations in the Polycomb repressive complex 2 (PRC2) core components EED or SUZ12. Genetic loss of either of these two genes results in complete loss of H3K27me3 and aberrant transcriptional programming in the affected tumors.</p>

Oncogenomics of Malignant Peripheral Nerve Sheath Tumors

14 variables across Demographics, Disease Events

Oncogenomics of Malignant Peripheral Nerve Sheath Tumors

Demographics (1)

Disease Events (1)

Other (12)