NHLBI TOPMed: The Cleveland Family Study (CFS)

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

D. Swerdlow, M. Holmes, Karoline B. Kuchenbaecker, et al.. (2012). Lancet (London, England). Cited 993 times. https://doi.org/10.1016/S0140-6736(12)60110-X

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Michael V. Holmes, C. Dale, L. Zuccolo, et al.. (2014). The BMJ. Cited 632 times. https://doi.org/10.1136/bmj.g4164

Racial differences in sleep-disordered breathing in African-Americans and Caucasians.

S. Redline, P. Tishler, M. Hans, et al.. (1997). American journal of respiratory and critical care medicine. Cited 613 times. https://doi.org/10.1164/AJRCCM.155.1.9001310

Sleep duration and biomarkers of inflammation.

Sanjay R. Patel, X. Zhu, A. Storfer‐Isser, et al.. (2009). Sleep. Cited 572 times. https://doi.org/10.1093/SLEEP/32.2.200

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Z. Dastani, M. Hivert, N. Timpson, et al.. (2012). PLoS Genetics. Cited 518 times. https://doi.org/10.1371/journal.pgen.1002607

Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing.

P. Tishler, E. Larkin, M. Schluchter, et al.. (2003). JAMA. Cited 517 times. https://doi.org/10.1001/JAMA.289.17.2230

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

B. Keating, Sam Tischfield, S. Murray, et al.. (2008). PLoS ONE. Cited 431 times. https://doi.org/10.1371/journal.pone.0003583

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

G. Lettre, Cameron D. Palmer, Taylor R. Young, et al.. (2011). PLoS Genetics. Cited 335 times. https://doi.org/10.1371/journal.pgen.1001300

The landscape of recombination in African Americans

A. Hinch, Arti Tandon, N. Patterson, et al.. (2011). Nature. Cited 334 times. https://doi.org/10.1038/nature10336

The familial aggregation of obstructive sleep apnea.

S. Redline, P. Tishler, T. Tosteson, et al.. (1995). American journal of respiratory and critical care medicine. Cited 289 times. https://doi.org/10.1164/ajrccm.151.3.7881656

A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry

K. Monda, K. Monda, Gary K. Chen, et al.. (2013). Nature genetics. Cited 255 times. https://doi.org/10.1038/ng.2608

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

N. Franceschini, Ervin F. Fox, Zhaogong Zhang, et al.. (2013). American journal of human genetics. Cited 189 times. https://doi.org/10.1016/j.ajhg.2013.07.010

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

E. Fox, J. H. Young, Yali Li, et al.. (2011). Human Molecular Genetics. Cited 189 times. https://doi.org/10.1093/hmg/ddr092

Whole genome scan for obstructive sleep apnea and obesity in African-American families.

L. Palmer, Sarah G Buxbaum, E. Larkin, et al.. (2004). American journal of respiratory and critical care medicine. Cited 165 times. https://doi.org/10.1164/RCCM.200304-493OC

Candidate Gene Association Resource (CARe): Design, Methods, and Proof of Concept

K. Musunuru, G. Lettre, Taylor R. Young, et al.. (2010). Circulation: Cardiovascular Genetics. Cited 149 times. https://doi.org/10.1161/CIRCGENETICS.109.882696

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

S. Ganesh, V. Tragante, Wei Guo, et al.. (2013). Human molecular genetics. Cited 145 times. https://doi.org/10.1093/hmg/dds555

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

M. Lanktree, Yiran Guo, Muhammed Murtaza, et al.. (2011). American journal of human genetics. Cited 142 times. https://doi.org/10.1016/j.ajhg.2010.11.007

Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

M. Sabater-Lleal, Jie Huang, D. Chasman, et al.. (2013). Circulation. Cited 141 times. https://doi.org/10.1161/CIRCULATIONAHA.113.002251

Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis

Sarah G Buxbaum, R. Elston, P. Tishler, et al.. (2002). Genetic Epidemiology. Cited 141 times. https://doi.org/10.1002/gepi.0170

A candidate gene study of obstructive sleep apnea in European Americans and African Americans.

E. Larkin, Sanjay R. Patel, Robert J. Goodloe, et al.. (2010). American journal of respiratory and critical care medicine. Cited 121 times. https://doi.org/10.1164/rccm.201002-0192OC

Genome-Wide Association Studies of the PR Interval in African Americans

J. Smith, J. Magnani, Cameron D. Palmer, et al.. (2011). PLoS Genetics. Cited 108 times. https://doi.org/10.1371/journal.pgen.1001304

Genome-wide meta-analyses of smoking behaviors in African Americans

S. David, S. David, S. David, et al.. (2012). Translational Psychiatry. Cited 103 times. https://doi.org/10.1038/tp.2012.41

Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

A. N’Diaye, Gary K. Chen, Cameron D. Palmer, et al.. (2011). PLoS Genetics. Cited 98 times. https://doi.org/10.1371/journal.pgen.1002298

Obstructive sleep apnea is associated with increased urinary albumin excretion.

Michael D. Faulx, A. Storfer‐Isser, H. Kirchner, et al.. (2007). Sleep. Cited 96 times. https://doi.org/10.1093/SLEEP/30.7.923

Shared genetic basis for obstructive sleep apnea and adiposity measures

Sanjay R. Patel, E. Larkin, Susan Redline. (2008). International Journal of Obesity. Cited 84 times. https://doi.org/10.1038/sj.ijo.0803803

Ventilatory-control abnormalities in familial sleep apnea.

S. Redline, Janice Leitner, Jean L. Arnold, et al.. (1997). American journal of respiratory and critical care medicine. Cited 84 times. https://doi.org/10.1164/AJRCCM.156.1.9610016

Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.

Xiaofeng Zhu, J. H. Young, Ervin F. Fox, et al.. (2011). Human molecular genetics. Cited 83 times. https://doi.org/10.1093/hmg/ddr113

The association of sudden unexpected infant death with obstructive sleep apnea.

P. Tishler, S. Redline, V. Ferrette, et al.. (1996). American journal of respiratory and critical care medicine. Cited 82 times. https://doi.org/10.1164/AJRCCM.153.6.8665046

Empirical evidence for "syndrome Z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures.

N. Nock, Li Li, E. Larkin, et al.. (2009). Sleep. Cited 78 times. https://doi.org/10.1093/SLEEP/32.5.615

Association of Genetic Loci with Sleep Apnea in European Americans and African-Americans: The Candidate Gene Association Resource (CARe)

Sanjay R. Patel, Robert J. Goodloe, Gourab De, et al.. (2012). PLoS ONE. Cited 77 times. https://doi.org/10.1371/journal.pone.0048836

Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak

E. Larkin, Sanjay R. Patel, S. Redline, et al.. (2006). Genetic Epidemiology. Cited 74 times. https://doi.org/10.1002/gepi.20127

Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland Family Study.

R. Mehra, Fang Xu, D. Babineau, et al.. (2010). American journal of respiratory and critical care medicine. Cited 63 times. https://doi.org/10.1164/rccm.201001-0020OC

GEE‐Based SNP Set Association Test for Continuous and Discrete Traits in Family‐Based Association Studies

Xuefeng Wang, Seunggeun Lee, Xiaofeng Zhu, et al.. (2013). Genetic Epidemiology. Cited 53 times. https://doi.org/10.1002/gepi.21763

The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension.

Sanjay R. Patel, E. Larkin, E. Mignot, et al.. (2007). Sleep. Cited 52 times. https://doi.org/10.1093/SLEEP/30.4.531

Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project

K. Musunuru, Siôn Romaine, G. Lettre, et al.. (2012). PLoS ONE. Cited 51 times. https://doi.org/10.1371/journal.pone.0036473

Heritability of upper airway dimensions derived using acoustic pharyngometry

Sanjay R. Patel, Jennifer Frame, E. Larkin, et al.. (2008). European Respiratory Journal. Cited 51 times. https://doi.org/10.1183/09031936.00029808

Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans

J. Smith, C. Avery, Daniel S. Evans, et al.. (2012). Circulation: Cardiovascular Genetics. Cited 48 times. https://doi.org/10.1161/CIRCGENETICS.112.962787

Novel Loci Associated With PR Interval in a Genome-Wide Association Study of 10 African American Cohorts

Anne M. Butler, Xiaoyan Yin, Daniel S. Evans, et al.. (2012). Circulation: Cardiovascular Genetics. Cited 48 times. https://doi.org/10.1161/CIRCGENETICS.112.963991

Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).

C. Wassel, L. Lange, B. Keating, et al.. (2011). Blood. Cited 43 times. https://doi.org/10.1182/blood-2010-06-289546

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium.

C. Wassel, C. Lamina, Vijay Nambi, et al.. (2012). Atherosclerosis. Cited 36 times. https://doi.org/10.1016/j.atherosclerosis.2012.01.039

Systems Biology Analyses of Gene Expression and Genome Wide Association Study Data in Obstructive Sleep Apnea

Yu Liu, Sanjay R. Patel, Rod K. Nibbe, et al.. (2011). Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. Cited 31 times. https://doi.org/10.1142/9789814335058_0003

Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants.

R. Deo, M. Nalls, C. Avery, et al.. (2013). Heart rhythm. Cited 29 times. https://doi.org/10.1016/j.hrthm.2012.11.014

Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts

E. Oelsner, T. Pottinger, K. M. Burkart, et al.. (2013). Biomarkers. Cited 27 times. https://doi.org/10.3109/1354750X.2012.762805

Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource

Ching-Ti Liu, M. Ng, D. Rybin, et al.. (2012). Diabetologia. Cited 22 times. https://doi.org/10.1007/s00125-012-2656-4

Using Linkage Analysis to Identify Quantitative Trait Loci for Sleep Apnea in Relationship to Body Mass Index

E. Larkin, Sanjay R. Patel, Robert C. Elston, et al.. (2008). Annals of Human Genetics. Cited 22 times. https://doi.org/10.1111/j.1469-1809.2008.00472.x

Study of the relationship between the interleukin-6 gene and obstructive sleep apnea.

E. Larkin, Sanjay R. Patel, Xiaofeng Zhu, et al.. (2010). Clinical and translational science. Cited 16 times.

Linkage of serum leptin levels in families with sleep apnea

E. Larkin, R. Elston, S. Patel, et al.. (2005). International Journal of Obesity. Cited 9 times. https://doi.org/10.1038/sj.ijo.0802872