NHLBI TOPMed: The Genetic Epidemiology of Asthma in Costa Rica

Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations

D. Torgerson, E. Ampleford, Grace Y. Chiu, et al.. (2011). Nature genetics. Cited 821 times. https://doi.org/10.1038/ng.888

A Common Genetic Variant Is Associated with Adult and Childhood Obesity

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Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.

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Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

B. Himes, G. M. Hunninghake, J. Baurley, et al.. (2009). American journal of human genetics. Cited 310 times. https://doi.org/10.1016/j.ajhg.2009.04.006

Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

D. Verlaan, Soizik Berlivet, G. M. Hunninghake, et al.. (2009). American journal of human genetics. Cited 287 times. https://doi.org/10.1016/j.ajhg.2009.08.007

MMP12, lung function, and COPD in high-risk populations.

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Asthma and ethnic minorities: socioeconomic status and beyond

E. Forno, J. Celedón. (2009). Current Opinion in Allergy and Clinical Immunology. Cited 185 times. https://doi.org/10.1097/ACI.0b013e3283292207

Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy.

M. Pistiner, D. Gold, H. Abdulkerim, et al.. (2008). The Journal of allergy and clinical immunology. Cited 179 times. https://doi.org/10.1016/j.jaci.2008.05.007

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

H. Lyon, H. Lyon, H. Lyon, et al.. (2007). PLoS Genetics. Cited 163 times. https://doi.org/10.1371/journal.pgen.0030061

Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica.

G. M. Hunninghake, M. Soto-Quiros, L. Avila, et al.. (2007). The Journal of allergy and clinical immunology. Cited 160 times. https://doi.org/10.1016/J.JACI.2006.12.609

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children.

S. Bunyavanich, S. Rifas-Shiman, T. Platts-Mills, et al.. (2014). The Journal of allergy and clinical immunology. Cited 140 times. https://doi.org/10.1016/j.jaci.2013.11.040

On the replication of genetic associations: timing can be everything!

J. Lasky-Su, H. Lyon, V. Emilsson, et al.. (2008). American journal of human genetics. Cited 133 times. https://doi.org/10.1016/j.ajhg.2008.01.018

TSLP polymorphisms are associated with asthma in a sex‐specific fashion

G. M. Hunninghake, G. M. Hunninghake, M. Soto-Quiros, et al.. (2010). Allergy. Cited 131 times. https://doi.org/10.1111/j.1398-9995.2010.02415.x

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications.

J. Howrylak, A. Fuhlbrigge, R. Strunk, et al.. (2014). The Journal of allergy and clinical immunology. Cited 121 times. https://doi.org/10.1016/J.JACI.2014.02.006

Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood.

G. M. Hunninghake, M. Soto-Quiros, L. Avila, et al.. (2007). The Journal of allergy and clinical immunology. Cited 120 times. https://doi.org/10.1016/J.JACI.2007.04.032

A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.

Sunita Sharma, K. Tantisira, V. Carey, et al.. (2010). American journal of respiratory and critical care medicine. Cited 106 times. https://doi.org/10.1164/rccm.200907-1009OC

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study.

V. Ortega, G. Hawkins, W. Moore, et al.. (2014). The Lancet. Respiratory medicine. Cited 103 times. https://doi.org/10.1016/S2213-2600(13)70289-3

Comprehensive testing of positionally cloned asthma genes in two populations.

C. Hersh, B. Raby, M. Soto-Quiros, et al.. (2007). American journal of respiratory and critical care medicine. Cited 101 times. https://doi.org/10.1164/RCCM.200704-592OC

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.

Heung-Woo Park, A. Dahlin, S. Tse, et al.. (2014). The Journal of allergy and clinical immunology. Cited 88 times. https://doi.org/10.1016/j.jaci.2013.12.1042

Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.

G. M. Hunninghake, J. Lasky-Su, M. Soto-Quiros, et al.. (2008). American journal of respiratory and critical care medicine. Cited 84 times. https://doi.org/10.1164/rccm.200711-1697OC

Genome‐wide association study of body mass index in 23 000 individuals with and without asthma

Erik Melén, Erik Melén, Erik Melén, et al.. (2013). Clinical & Experimental Allergy. Cited 77 times. https://doi.org/10.1111/cea.12054

PRKCA: a positional candidate gene for body mass index and asthma.

A. Murphy, K. Tantisira, M. Soto-Quiros, et al.. (2009). American journal of human genetics. Cited 77 times. https://doi.org/10.1016/j.ajhg.2009.06.011

Risk factors and predictive clinical scores for asthma exacerbations in childhood.

E. Forno, A. Fuhlbrigge, M. Soto-Quiros, et al.. (2010). Chest. Cited 75 times. https://doi.org/10.1378/chest.09-2426

Genome-wide interaction studies reveal sex-specific asthma risk alleles.

R. Myers, Nicole M. Scott, W. Gauderman, et al.. (2014). Human molecular genetics. Cited 71 times. https://doi.org/10.1093/hmg/ddu222

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis

S. Bunyavanich, E. Schadt, B. Himes, et al.. (2014). BMC Medical Genomics. Cited 67 times. https://doi.org/10.1186/1755-8794-7-48

Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.

Sunita Sharma, B. Raby, G. M. Hunninghake, et al.. (2009). American journal of respiratory and critical care medicine. Cited 66 times. https://doi.org/10.1164/rccm.200808-1268OC

Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.

G. M. Hunninghake, M. Soto-Quiros, J. Lasky-Su, et al.. (2008). The Journal of allergy and clinical immunology. Cited 63 times. https://doi.org/10.1016/j.jaci.2008.03.015

Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.

R. Du, A. Litonjua, K. Tantisira, et al.. (2012). The Journal of allergy and clinical immunology. Cited 59 times. https://doi.org/10.1016/j.jaci.2011.09.034

Genome-wide association study of the age of onset of childhood asthma.

E. Forno, J. Lasky-Su, B. Himes, et al.. (2012). The Journal of allergy and clinical immunology. Cited 58 times. https://doi.org/10.1016/j.jaci.2012.03.020

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.

PhD Albert M. Levin, ScD Rasika A. Mathias, Mph Lili Huang, et al.. (2013). The Journal of allergy and clinical immunology. Cited 58 times. https://doi.org/10.1016/j.jaci.2012.10.002

Genome-wide association analysis of circulating vitamin D levels in children with asthma

J. Lasky-Su, Nancy E. Lange, John M. Brehm, et al.. (2012). Human Genetics. Cited 56 times. https://doi.org/10.1007/s00439-012-1185-z

A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.

Sunita Sharma, Xiaobo Zhou, Derek M Thibault, et al.. (2014). The Journal of allergy and clinical immunology. Cited 56 times. https://doi.org/10.1016/j.jaci.2014.04.011

A genome-wide association study of bronchodilator response in asthmatics

Q. Duan, J. Lasky-Su, B. Himes, et al.. (2013). The pharmacogenomics journal. Cited 52 times. https://doi.org/10.1038/tpj.2013.5

Genetics of asthma: potential implications for reducing asthma disparities.

C. Scirica, J. Celedón. (2007). Chest. Cited 37 times. https://doi.org/10.1378/CHEST.07-1905

Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes

Nancy E. Lange, Xiaobo Zhou, J. Lasky-Su, et al.. (2011). BMC Medical Genetics. Cited 35 times. https://doi.org/10.1186/1471-2350-12-26

Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness

Sunita Sharma, A. Murphy, M. Soto-Quiros, et al.. (2009). European Respiratory Journal. Cited 34 times. https://doi.org/10.1183/09031936.00113008

Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica.

B. Raby, M. Soto-Quiros, L. Avila, et al.. (2007). Human molecular genetics. Cited 32 times. https://doi.org/10.1093/HMG/DDL447

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.

R. Myers, B. Himes, Christopher R. Gignoux, et al.. (2012). The Journal of allergy and clinical immunology. Cited 32 times. https://doi.org/10.1016/j.jaci.2012.07.054

Risk factors for allergic rhinitis in Costa Rican children with asthma

S. Bunyavanich, M. Soto-Quiros, L. Avila, et al.. (2010). Allergy. Cited 30 times. https://doi.org/10.1111/j.1398-9995.2009.02159.x

Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica.

N. Ly, M. Soto-Quiros, L. Avila, et al.. (2008). Chest. Cited 29 times. https://doi.org/10.1378/CHEST.07-2130

Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica

J. Celedón, M. Soto-Quiros, L. Avila, et al.. (2006). Human Genetics. Cited 27 times. https://doi.org/10.1007/s00439-006-0255-5

Asthma-susceptibility variants identified using probands in case-control and family-based analyses

B. Himes, J. Lasky-Su, A. Wu, et al.. (2010). BMC Medical Genetics. Cited 24 times. https://doi.org/10.1186/1471-2350-11-122

Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.

A. Wu, B. Himes, J. Lasky-Su, et al.. (2014). The Journal of allergy and clinical immunology. Cited 22 times. https://doi.org/10.1016/j.jaci.2013.09.037

Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica

C. Hersh, M. Soto-Quiros, L. Avila, et al.. (2006). Thorax. Cited 19 times. https://doi.org/10.1136/thx.2006.067934

Association of SERPINE2 with asthma.

B. Himes, B. Klanderman, J. Ziniti, et al.. (2011). Chest. Cited 19 times. https://doi.org/10.1378/chest.10-2973

Statin-induced changes in gene expression in EBV-transformed and native B-cells.

Eugene Bolotin, Angela D Armendáriz, Kyungpil Kim, et al.. (2014). Human molecular genetics. Cited 19 times. https://doi.org/10.1093/hmg/ddt512

Family history, environmental exposures in early life, and childhood asthma.

N. Ly, J. Celedón. (2007). The Journal of allergy and clinical immunology. Cited 12 times. https://doi.org/10.1016/J.JACI.2007.05.045

Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases

Michael J. McGeachie, George L. Clemmer, J. Lasky-Su, et al.. (2014). Genomics Data. Cited 9 times. https://doi.org/10.1016/j.gdata.2014.04.004