<p>The transcriptome of pulmonary arterial endothelial cells from healthy lungs and from lungs of patients with idiopathic pulmonary arterial hypertension have been analyzed and specific differences in disease-relevant pathways were identified. The genes identified as altered in these patients have direct effects on pulmonary arterial endothelial cell function. This finding may underlie the inability of the pulmonary vasculature to respond to and repair the damage observed in pulmonary hypertension. </p>

Transcriptome Profile of Endothelial Cells in PAH Patients vs Controls

2 selected publications including "Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that ..." (191 citations)

Transcriptome Profile of Endothelial Cells in PAH Patients vs Controls

Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.

The Ying-yang of RAR and AP-1: cancer treatment without overt toxicity