<p>Acute Myeloid Leukemia (AML) remains a clinical challenge since most patients diagnosed with AML will die from the disease. Some patients harbor treatment-refractory disease and many others relapse with disease that in many cases is resistant to treatments. Our study was designed to understand the molecular basis of disease progression in AML through assessing genomics signatures in patient specimens collected through an international collaboration which assembled samples from 138 AML patients which experienced disease relapse and normal hematopoietic cells (n=15).</p> <p>It is hoped that this resource will help researchers understand mechanisms of disease relapse in AML and contribute to the general pool of data available for analyses for this disease and general research use.</p>

Epigenomics Studies in Acute Myeloid Leukemia (AML)

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence.

Dynamic evolution of clonal epialleles revealed by methclone

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia