Population Genetics Analysis Program: Immunity to Vaccines/Infections (NIAID/NIH)

Systems biology approaches to new vaccine development.

A. Oberg, R. Kennedy, Peter W. Li, et al.. (2011). Current opinion in immunology. Cited 113 times. https://doi.org/10.1016/j.coi.2011.04.005

The immunology of smallpox vaccines

R. Kennedy, I. Ovsyannikova, R. Jacobson, et al.. (2009). Current Opinion in Immunology. Cited 100 times. https://doi.org/10.1016/j.coi.2009.04.004

Genome-wide association study of antibody response to smallpox vaccine.

I. Ovsyannikova, R. Kennedy, M. O’byrne, et al.. (2012). Vaccine. Cited 83 times. https://doi.org/10.1016/j.vaccine.2012.04.055

Gender effects on humoral immune responses to smallpox vaccine.

R. Kennedy, I. Ovsyannikova, V. Pankratz, et al.. (2009). Vaccine. Cited 83 times. https://doi.org/10.1016/j.vaccine.2009.01.086

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients

R. Kennedy, I. Ovsyannikova, bullet V Shane, et al.. (2012). Human Genetics. Cited 77 times. https://doi.org/10.1007/s00439-012-1174-2

Smallpox vaccines for biodefense.

R. Kennedy, I. Ovsyannikova, G. Poland. (2009). Vaccine. Cited 62 times. https://doi.org/10.1016/j.vaccine.2009.07.103

Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals.

I. Haralambieva, I. Ovsyannikova, R. Kennedy, et al.. (2013). Human immunology. Cited 46 times. https://doi.org/10.1016/j.humimm.2013.06.031

Discovery of naturally processed and HLA-presented class I peptides from vaccinia virus infection using mass spectrometry for vaccine development.

K. L. Johnson, I. Ovsyannikova, C. J. Mason, et al.. (2009). Vaccine. Cited 45 times. https://doi.org/10.1016/j.vaccine.2009.09.126

Genome-wide genetic associations with IFNγ response to smallpox vaccine

R. Kennedy, I. Ovsyannikova, bullet V Shane, et al.. (2012). Human Genetics. Cited 43 times. https://doi.org/10.1007/s00439-012-1179-x

Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans.

I. Haralambieva, I. Ovsyannikova, N. Dhiman, et al.. (2011). The Journal of infectious diseases. Cited 37 times. https://doi.org/10.1093/infdis/jir268

Transcriptomic Profiles of High and Low Antibody Responders to Smallpox Vaccine

R. Kennedy, A. Oberg, I. Ovsyannikova, et al.. (2013). Genes and immunity. Cited 34 times. https://doi.org/10.1038/gene.2013.14

Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.

I. Ovsyannikova, I. Haralambieva, R. Kennedy, et al.. (2012). Gene. Cited 34 times. https://doi.org/10.1016/j.gene.2012.08.021

ReliefSeq: A Gene-Wise Adaptive-K Nearest-Neighbor Feature Selection Tool for Finding Gene-Gene Interactions and Main Effects in mRNA-Seq Gene Expression Data

B. McKinney, Bill C. White, D. Grill, et al.. (2013). PLoS ONE. Cited 33 times. https://doi.org/10.1371/journal.pone.0081527

Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine.

I. Ovsyannikova, R. Vierkant, V. Pankratz, et al.. (2011). The Journal of infectious diseases. Cited 33 times. https://doi.org/10.1093/infdis/jir167

HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study

I. Ovsyannikova, V. Pankratz, Hannah M. Salk, et al.. (2014). Human Genetics. Cited 27 times. https://doi.org/10.1007/s00439-014-1449-x

The identification of HLA class II-restricted T cell epitopes to vaccinia virus membrane proteins

R. Kennedy, G. Poland. (2010). Virology. Cited 25 times. https://doi.org/10.1016/j.virol.2010.09.013

High-dimensional gene expression profiling studies in high and low responders to primary smallpox vaccination.

I. Haralambieva, A. Oberg, N. Dhiman, et al.. (2012). The Journal of infectious diseases. Cited 23 times. https://doi.org/10.1093/infdis/jis546

The personal touch: strategies toward personalized vaccines and predicting immune responses to them

R. Kennedy, I. Ovsyannikova, N. Lambert, et al.. (2014). Expert Review of Vaccines. Cited 21 times. https://doi.org/10.1586/14760584.2014.905744

Genetic variation in IL18R1 and IL18 genes and Inteferon γ ELISPOT response to smallpox vaccination: an unexpected relationship.

I. Ovsyannikova, I. Haralambieva, R. Kennedy, et al.. (2013). The Journal of infectious diseases. Cited 19 times. https://doi.org/10.1093/infdis/jit341

Statistical Approach To Estimate Vaccinia-Specific Neutralizing Antibody Titers Using a High-Throughput Assay

R. Kennedy, V. Pankratz, E. Swanson, et al.. (2009). Clinical and Vaccine Immunology. Cited 19 times. https://doi.org/10.1128/CVI.00109-09

Cytokine production associated with smallpox vaccine responses.

Whitney L. Simon, Hannah M. Salk, I. Ovsyannikova, et al.. (2014). Immunotherapy. Cited 18 times. https://doi.org/10.2217/imt.14.72

Correlations Between Vaccinia-Specific Immune Responses Within a Cohort of Armed Forces Members

Benjamin J. Umlauf, I. Ovsyannikova, I. Haralambieva, et al.. (2011). Viral Immunology. Cited 16 times. https://doi.org/10.1089/vim.2011.0029

Soft truncation thresholding for gene set analysis of RNA-seq data: Application to a vaccine study

B. Fridley, G. Jenkins, D. Grill, et al.. (2013). Scientific Reports. Cited 15 times. https://doi.org/10.1038/srep02898

Detection of vaccinia virus-specific IFNγ and IL-10 secretion from human PBMCs and CD8⁺ T cells by ELISPOT.

Benjamin J. Umlauf, N. A. Pinsky, I. Ovsyannikova, et al.. (2012). Methods in molecular biology. Cited 15 times. https://doi.org/10.1007/978-1-61779-325-7_16

Optimizing high dimensional gene expression studies for immune response following smallpox vaccination using Taqman® low density immune arrays.

A. Oberg, N. Dhiman, D. Grill, et al.. (2011). Journal of immunological methods. Cited 7 times. https://doi.org/10.1016/j.jim.2011.01.011

Response surface methodology to determine optimal measles-specific cytokine responses in human peripheral blood mononuclear cells.

Matthew J Taylor, I. Haralambieva, R. Vierkant, et al.. (2012). Journal of immunological methods. Cited 2 times. https://doi.org/10.1016/j.jim.2012.06.004