<p>PD-1 is an important immune checkpoint inhibitor that shows great promise in the clinic, particularly for melanoma and lung cancers. Since PD-1 is also expressed on infiltrating CD4+ Treg and Teffector cells in glioblastoma, we sought to better understand the role of PD-1 on these infiltrating CD4+ Treg and Teffector cells. To this end, we performed functional and transcriptional profiling using CD4+ Treg and Teffector cells isolated from healthy donors and glioblastoma patients (from both tumors and blood).</p>

PD-1+ and PD-1- CD4+ Teff and Treg cells in Glioblastoma and Health

Glioblastoma study with RNA-Seq data on dbGaP (10 participants)

PD-1+ and PD-1- CD4+ Teff and Treg cells in Glioblastoma and Health

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