<p>This study compares DNA mutations detected in matched primary and metastatic colorectal cancer samples from 18 individuals across 1,321 genes. We found many more mutations were shared between tumor pairs (avg. 33.3 mutations/tumor) than were discordant (avg. 2.3 mutations / tumor). Nearly all tumors showed at least one discordance, and these were observed in genes known to be involved in colorectal cancer progression. Therefore, although primary and metastatic colorectal tumors are highly genetically concordant, evidence exists for discordance, which has clinical implications especially in situations of chemotherapy resistance or insensitivity.</p>

Differential Mutations in Matched Primary and Metastatic Colorectal    Cancers

1 selected publication including "Co-Evolution of Somatic Variation in Primary and Metastatic Colorectal..." (39 citations)

Differential Mutations in Matched Primary and Metastatic Colorectal Cancers

Co-Evolution of Somatic Variation in Primary and Metastatic Colorectal Cancer May Expand Biopsy Indications in the Molecular Era