<p>Asthma is a complex disease where the interplay between genetic factors and environmental exposures influences susceptibility and disease prognosis. Asthmatics of African descent tend to have more severe asthma and more severe clinical symptoms than individuals of European ancestry. Advances in genetic and genomic technologies have revolutionized gene discovery for several complex diseases, but going to the next step in gene discovery for asthma among populations of African descent requires considering unique characteristics of this ethnic group, including adequate sample sizes and population stratification due to (European and African) admixture. Thus far, coverage of common genetic markers both in public databases and commercially available SNP chips has been inadequate to detect and measure genetic associations among African admixed populations. The aim of this study was therefore to catalog genetic diversity in populations of African descent, especially those whose ancestry reflects the African Diaspora in the Americas.</p>

Consortium on Asthma among African-ancestry Populations in the Americas

Assembly of a pan-genome from deep sequencing of 910 humans of African descent

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome