NHLBI TOPMed: Genetic Study of Atherosclerosis Risk (GeneSTAR)

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Heritability of Platelet Responsiveness to Aspirin in Activation Pathways Directly and Indirectly Related to Cyclooxygenase-1

N. Faraday, L. Yanek, R. Mathias, et al. (2007). Circulation. Cited 152 times. https://doi.org/10.1161/CIRCULATIONAHA.106.667584

Heritability of platelet function in families with premature coronary artery disease

P. Bray, R. Mathias, N. Faraday, et al. (2007). Journal of Thrombosis and Haemostasis. Cited 106 times. https://doi.org/10.1111/j.1538-7836.2007.02618.x

A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans

R. Qayyum, B. Snively, E. Ziv, et al. (2012). PLoS Genetics. Cited 106 times. https://doi.org/10.1371/journal.pgen.1002491

A Novel Variant in the Platelet Endothelial Aggregation Receptor-1 Gene Is Associated With Increased Platelet Aggregability

J. Herrera-Galeano, D. Becker, Alexander F. Wilson, et al. (2008). Arteriosclerosis, Thrombosis, and Vascular Biology. Cited 105 times. https://doi.org/10.1161/ATVBAHA.108.168971

Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.

N. Faraday, L. Yanek, X. P. Yang, et al. (2011). Blood. Cited 105 times. https://doi.org/10.1182/blood-2010-11-320788

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.

J. Eicher, Nathalie Chami, T. Kacprowski, et al. (2016). American journal of human genetics. Cited 89 times. https://doi.org/10.1016/j.ajhg.2016.05.005

Effect of obesity on platelet reactivity and response to low-dose aspirin.

B. Bordeaux, R. Qayyum, L. Yanek, et al. (2010). Preventive cardiology. Cited 80 times. https://doi.org/10.1111/j.1751-7141.2009.00058.x

Association of Single Nucleotide Polymorphisms on Chromosome 9p21.3 With Platelet Reactivity: A Potential Mechanism for Increased Vascular Disease

K. Musunuru, W. Post, W. Herzog, et al. (2010). Circulation: Cardiovascular Genetics. Cited 77 times. https://doi.org/10.1161/CIRCGENETICS.109.923508

Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population.

N. Faraday, D. Becker, L. Yanek, et al. (2006). The American journal of cardiology. Cited 67 times. https://doi.org/10.1016/J.AMJCARD.2006.04.015

Efficient Generation of Megakaryocytes From Human Induced Pluripotent Stem Cells Using Food and Drug Administration‐Approved Pharmacological Reagents

Yanfeng Liu, Ying Wang, Yongxing Gao, et al. (2015). STEM CELLS Translational Medicine. Cited 66 times. https://doi.org/10.5966/sctm.2014-0183

Genome-wide association study of platelet aggregation in African Americans

R. Qayyum, L. Becker, D. Becker, et al. (2015). BMC Genetics. Cited 58 times. https://doi.org/10.1186/s12863-015-0217-9

Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular disease.

R. Qayyum, D. Becker, L. Yanek, et al. (2008). The American journal of cardiology. Cited 53 times. https://doi.org/10.1016/j.amjcard.2007.12.038

Casual chocolate consumption and inhibition of platelet function.

B. Bordeaux, L. Yanek, T. Moy, et al. (2007). Preventive cardiology. Cited 46 times. https://doi.org/10.1111/J.1520-037X.2007.06693.X

Pharmacogenomics of platelet responsiveness to aspirin.

N. Faraday, D. Becker, L. Becker. (2007). Pharmacogenomics. Cited 33 times. https://doi.org/10.2217/14622416.8.10.1413

Targeted Deep Resequencing Identifies Coding Variants in the PEAR1 Gene That Play a Role in Platelet Aggregation

Yoonhee Kim, B. Suktitipat, L. Yanek, et al. (2013). PLoS ONE. Cited 31 times. https://doi.org/10.1371/journal.pone.0064179

Genetic Regulation of Platelet Receptor Expression and Function: Application in Clinical Practice and Drug Development

Marlene S. Williams, Ethan J. Weiss, M. Sabatine, et al. (2010). Arteriosclerosis, Thrombosis, and Vascular Biology. Cited 24 times. https://doi.org/10.1161/ATVBAHA.110.218131

Leukocyte count is associated with increased platelet reactivity and diminished response to aspirin in healthy individuals with a family history of coronary artery disease.

N. Faraday, L. Yanek, Dhananjay Vaidya, et al. (2009). Thrombosis research. Cited 23 times. https://doi.org/10.1016/j.thromres.2008.12.031

Targeted deep sequencing of the PEAR1 locus for platelet aggregation in European and African American families

A. Keramati, L. Yanek, K. Iyer, et al. (2019). Platelets. Cited 18 times. https://doi.org/10.1080/09537104.2018.1447659

A common variant in the Von Willebrand factor gene is associated with multiple functional consequences

Dhananjay Vaidya, L. Yanek, J. Herrera-Galeano, et al. (2010). American Journal of Hematology. Cited 17 times. https://doi.org/10.1002/ajh.21859

Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation

Ming-Huei Chen, L. Yanek, J. Backman, et al. (2019). Platelets. Cited 15 times. https://doi.org/10.1080/09537104.2017.1384538

Native Platelet Aggregation and Response to Aspirin in Persons With the Metabolic Syndrome and Its Components

Dhananjay Vaidya, L. Yanek, N. Faraday, et al. (2009). Metabolic Syndrome and Related Disorders. Cited 14 times. https://doi.org/10.1089/met.2008.0083

Greater Collagen‐Induced Platelet Aggregation Following Cyclooxygenase 1 Inhibition Predicts Incident Acute Coronary Syndromes

R. Qayyum, D. Becker, L. Yanek, et al. (2015). Clinical and Translational Science. Cited 14 times. https://doi.org/10.1111/cts.12195

Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation

J. Eicher, Ming-Huei Chen, A. Pitsillides, et al. (2017). Thrombosis and Haemostasis. Cited 11 times. https://doi.org/10.1160/TH16-09-0677

Diabetes and Platelet Response to Low-Dose Aspirin

Mohammed E. Al-Sofiani, L. Yanek, N. Faraday, et al. (2018). The Journal of Clinical Endocrinology & Metabolism. Cited 10 times. https://doi.org/10.1210/jc.2018-01254

Integrity of Induced Pluripotent Stem Cell (iPSC) Derived Megakaryocytes as Assessed by Genetic and Transcriptomic Analysis

K. Kammers, M. Taub, I. Ruczinski, et al. (2017). PLoS ONE. Cited 8 times. https://doi.org/10.1371/journal.pone.0167794