NHLBI TOPMed: HyperGEN - Genetics of Left Ventricular (LV) Hypertrophy

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension.

Xiaofeng Zhu, Tao Feng, Tao Feng, et al.. (2015). American journal of human genetics. Cited 367 times. https://doi.org/10.1016/j.ajhg.2014.11.011

Normal limits in relation to age, body size and gender of two-dimensional echocardiographic aortic root dimensions in persons ≥15 years of age.

R. Devereux, G. de Simone, D. Arnett, et al.. (2012). The American journal of cardiology. Cited 365 times. https://doi.org/10.1016/j.amjcard.2012.05.063

Effect of Type 2 Diabetes Mellitus on Left Ventricular Geometry and Systolic Function in Hypertensive Subjects: Hypertension Genetic Epidemiology Network (HyperGEN) Study

V. Palmieri, J. Bella, D. Arnett, et al.. (2001). Circulation: Journal of the American Heart Association. Cited 355 times. https://doi.org/10.1161/01.CIR.103.1.102

A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry

K. Monda, K. Monda, Gary K. Chen, et al.. (2013). Nature genetics. Cited 255 times. https://doi.org/10.1038/ng.2608

Differences in Left Ventricular Structure Between Black and White Hypertensive Adults: The Hypertension Genetic Epidemiology Network Study

J. Kizer, D. Arnett, J. Bella, et al.. (2004). Hypertension: Journal of the American Heart Association. Cited 218 times. https://doi.org/10.1161/01.HYP.0000128738.94190.9f

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

M. Mangino, Shih-Jen Hwang, T. Spector, et al.. (2012). Human Molecular Genetics. Cited 217 times. https://doi.org/10.1093/hmg/dds382

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

N. Franceschini, Ervin F. Fox, Zhaogong Zhang, et al.. (2013). American journal of human genetics. Cited 189 times. https://doi.org/10.1016/j.ajhg.2013.07.010

Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study

G. de Simone, V. Palmieri, J. Bella, et al.. (2002). Journal of Hypertension. Cited 177 times. https://doi.org/10.1097/00004872-200202000-00024

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

Ching‐Ti Liu, K. Monda, K. Taylor, et al.. (2013). PLoS Genetics. Cited 142 times. https://doi.org/10.1371/journal.pgen.1003681

Aortic Root Dilatation at Sinuses of Valsalva and Aortic Regurgitation in Hypertensive and Normotensive Subjects: The Hypertension Genetic Epidemiology Network Study

V. Palmieri, J. Bella, D. Arnett, et al.. (2001). Hypertension: Journal of the American Heart Association. Cited 142 times. https://doi.org/10.1161/01.HYP.37.5.1229

Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study).

V. Palmieri, G. Simone, Donna K. Arnett, et al.. (2001). The American journal of cardiology. Cited 127 times. https://doi.org/10.1016/S0002-9149(01)02054-9

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Ying Wu, L. Waite, A. Jackson, et al.. (2013). PLoS Genetics. Cited 121 times. https://doi.org/10.1371/journal.pgen.1003379

Definition of phenotype.

M. Wojczynski, H. Tiwari. (2008). Advances in genetics. Cited 116 times. https://doi.org/10.1016/S0065-2660(07)00404-X

Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study.

G. de Simone, D. Kitzman, M. Chinali, et al.. (2005). European heart journal. Cited 113 times. https://doi.org/10.1093/EURHEARTJ/EHI019

Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.

B. Freedman, P. Hicks, Meredith A. Bostrom, et al.. (2009). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. Cited 108 times. https://doi.org/10.1093/ndt/gfp316

A genome scan for renal function among hypertensives: the HyperGEN study.

Andrew T. DeWan, Donna K. Arnett, Larry D. Atwood, et al.. (2001). American journal of human genetics. Cited 84 times. https://doi.org/10.1086/316927

Sibling correlation of left ventricular mass and geometry in hypertensive African Americans and whites: the HyperGEN study. Hypertension Genetic Epidemiology Network.

Donna K. Arnett, Yuling Hong, J. Bella, et al.. (2001). American journal of hypertension. Cited 80 times. https://doi.org/10.1016/S0895-7061(01)02200-2

DCAF4, a novel gene associated with leucocyte telomere length

M. Mangino, L. Christiansen, Rivka C. Stone, et al.. (2015). Journal of Medical Genetics. Cited 75 times. https://doi.org/10.1136/jmedgenet-2014-102681

Polymorphisms in the Nonmuscle Myosin Heavy Chain 9 Gene (MYH9) Are Associated with Albuminuria in Hypertensive African Americans: The HyperGEN Study

B. Freedman, J. Kopp, C. Winkler, et al.. (2009). American Journal of Nephrology. Cited 75 times. https://doi.org/10.1159/000194791

Gender difference in diastolic function in hypertension (the HyperGEN study).

J. Bella, V. Palmieri, D. Kitzman, et al.. (2002). The American journal of cardiology. Cited 69 times. https://doi.org/10.1016/S0002-9149(02)02274-9

Association of inappropriate left ventricular mass with systolic and diastolic dysfunction: the HyperGEN study.

G. de Simone, D. Kitzman, V. Palmieri, et al.. (2004). American journal of hypertension. Cited 64 times. https://doi.org/10.1016/J.AMJHYPER.2004.04.008

Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults: The HyperGEN Study

R. Devereux, J. Bella, V. Palmieri, et al.. (2001). Hypertension: Journal of the American Heart Association. Cited 63 times. https://doi.org/10.1161/01.HYP.38.3.417

Review and Evaluation of Methods Correcting for Population Stratification with a Focus on Underlying Statistical Principles

H. Tiwari, J. Barnholtz-Sloan, N. Wineinger, et al.. (2008). Human Heredity. Cited 62 times. https://doi.org/10.1159/000119107

Genome-Wide Association Study of Cardiac Structure and Systolic Function in African Americans: The Candidate Gene Association Resource (CARe) Study

E. Fox, S. Musani, M. Barbalić, et al.. (2013). Circulation: Cardiovascular Genetics. Cited 59 times. https://doi.org/10.1161/CIRCGENETICS.111.962365

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Ching‐Ti Liu, S. Raghavan, S. Raghavan, et al.. (2016). American journal of human genetics. Cited 57 times. https://doi.org/10.1016/j.ajhg.2016.05.006

Genetic Variation in NCAM1 Contributes to Left Ventricular Wall Thickness in Hypertensive Families

D. Arnett, K. Meyers, R. Devereux, et al.. (2011). Circulation Research. Cited 57 times. https://doi.org/10.1161/CIRCRESAHA.110.239210

An Empirical Comparison of Meta‐analysis and Mega‐analysis of Individual Participant Data for Identifying Gene‐Environment Interactions

Y. Sung, K. Schwander, D. Arnett, et al.. (2014). Genetic Epidemiology. Cited 52 times. https://doi.org/10.1002/gepi.21800

Relationship Between Left Ventricular Diastolic Relaxation and Systolic Function in Hypertension: The Hypertension Genetic Epidemiology Network (HyperGEN) Study

J. Bella, V. Palmieri, Jennifer E Liu, et al.. (2001). Hypertension: Journal of the American Heart Association. Cited 51 times. https://doi.org/10.1161/01.HYP.38.3.424

Genome-Wide Detection of Allele Specific Copy Number Variation Associated with Insulin Resistance in African Americans from the HyperGEN Study

M. Irvin, N. Wineinger, T. Rice, et al.. (2011). PLoS ONE. Cited 50 times. https://doi.org/10.1371/journal.pone.0024052

Between Candidate Genes and Whole Genomes: Time for Alternative Approaches in Blood Pressure Genetics

Jacob J Basson, Jeannette Simino, D. Rao. (2012). Current Hypertension Reports. Cited 49 times. https://doi.org/10.1007/s11906-011-0241-8

Body composition and fat distribution influence systemic hemodynamics in the absence of obesity: the HyperGEN Study.

G. Simone, R. Devereux, J. Kizer, et al.. (2005). The American journal of clinical nutrition. Cited 49 times. https://doi.org/10.1093/AJCN/81.4.757

Associations between angiotensinogen gene variants and left ventricular mass and function in the HyperGEN study.

Weihong Tang, R. Devereux, D. Rao, et al.. (2002). American heart journal. Cited 45 times. https://doi.org/10.1067/MHJ.2002.121926

Interarm differences in seated systolic and diastolic blood pressure: the Hypertension Genetic Epidemiology Network study

Donna K. Arnett, Weihong Tang, M. Province, et al.. (2005). Journal of Hypertension. Cited 43 times. https://doi.org/10.1097/01.hjh.0000170376.23461.f7

Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans

Emily Olfson, N. Saccone, Eric O Johnson, et al.. (2015). Molecular Psychiatry. Cited 41 times. https://doi.org/10.1038/mp.2015.105

Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network study

Felizen S. Agno, M. Chinali, J. Bella, et al.. (2005). Journal of Hypertension. Cited 41 times. https://doi.org/10.1097/01.hjh.0000163157.14493.c7

Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study

D. Arnett, R. Devereux, D. Rao, et al.. (2009). Journal of Hypertension. Cited 38 times. https://doi.org/10.1097/HJH.0b013e32832be612

Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study.

Joanlise M. Leon, B. Freedman, Michael B. Miller, et al.. (2007). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. Cited 38 times. https://doi.org/10.1093/NDT/GFL674

A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction

Jacquelyn Y. Taylor, K. Schwander, S. Kardia, et al.. (2016). Scientific Reports. Cited 34 times. https://doi.org/10.1038/srep18812

Gene-Environment Interaction for Hypertension Among African American Women Across Generations

Jacquelyn Y. Taylor, Yan V. Sun, S. Hunt, et al.. (2010). Biological Research For Nursing. Cited 32 times. https://doi.org/10.1177/1099800410371225

Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy.

Weihong Tang, D. Arnett, R. Devereux, et al.. (2005). American heart journal. Cited 32 times. https://doi.org/10.1016/J.AHJ.2004.12.004

Statistical issues in the analysis of DNA Copy Number Variations

N. Wineinger, Richard E. Kennedy, Stephen Erickson, et al.. (2008). International journal of computational biology and drug design. Cited 30 times. https://doi.org/10.1504/IJCBDD.2008.022208

Genome-Wide Linkage Mapping for Valve Calcification Susceptibility Loci in Hypertensive Sibships: The Hypertension Genetic Epidemiology Network Study

J. Bella, Weihong Tang, A. Kraja, et al.. (2007). Hypertension. Cited 30 times. https://doi.org/10.1161/01.HYP.0000256957.10242.75

PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

N. Tran, S. Aslibekyan, H. Tiwari, et al.. (2015). Frontiers in Genetics. Cited 28 times. https://doi.org/10.3389/fgene.2015.00136

Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) Study.

M. Chinali, G. de Simone, Jennifer E Liu, et al.. (2005). American journal of hypertension. Cited 28 times. https://doi.org/10.1016/J.AMJHYPER.2005.01.005

Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study.

V. Palmieri, D. Arnett, M. Roman, et al.. (2002). The American journal of medicine. Cited 28 times. https://doi.org/10.1016/S1062-1458(02)00934-0

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study

G. de Simone, M. Roman, M. De Marco, et al.. (2015). Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. Cited 27 times. https://doi.org/10.1161/JAHA.115.002309

Relation of albuminuria to left ventricular mass (from the HyperGEN Study).

L. Djoussé, J. Kochar, S. Hunt, et al.. (2008). The American journal of cardiology. Cited 27 times. https://doi.org/10.1016/j.amjcard.2007.07.065

Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: the HyperGEN study.

R. Devereux, G. de Simone, V. Palmieri, et al.. (2002). American journal of hypertension. Cited 27 times. https://doi.org/10.1016/S0895-7061(02)03080-7

Alcohol consumption and plasma atrial natriuretic peptide (from the HyperGEN study).

L. Djoussé, S. Hunt, J. Eckfeldt, et al.. (2006). The American journal of cardiology. Cited 25 times. https://doi.org/10.1016/J.AMJCARD.2006.03.041

Associations of aortic and mitral regurgitation with body composition and myocardial energy expenditure in adults with hypertension: the Hypertension Genetic Epidemiology Network study.

V. Palmieri, J. Bella, D. Arnett, et al.. (2003). American heart journal. Cited 24 times. https://doi.org/10.1016/S0002-8703(03)00099-1

Whole-exome Sequencing and an iPSC-Derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy

Degui Zhi, M. Irvin, C. Gu, et al.. (2012). Frontiers in Genetics. Cited 21 times. https://doi.org/10.3389/fgene.2012.00092

Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study

N. Wineinger, A. Patki, Kristin J Meyers, et al.. (2011). BMC Medical Genomics. Cited 19 times. https://doi.org/10.1186/1755-8794-4-4

Copy number variations associated with obesity related traits in African Americans: a joint analysis between GENOA and HyperGEN

Wei Zhao, N. Wineinger, H. Tiwari, et al.. (2012). Obesity (Silver Spring, Md.). Cited 18 times. https://doi.org/10.1038/oby.2012.162

Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: The HyperGEN Study

Amy I. Lynch, Weihong Tang, Gang Shi, et al.. (2011). Journal of human hypertension. Cited 18 times. https://doi.org/10.1038/jhh.2010.131

A Population Association Study of Angiotensinogen Polymorphisms and Haplotypes With Left Ventricular Phenotypes

L. Rasmussen‐Torvik, K. North, C. Gu, et al.. (2005). Hypertension. Cited 18 times. https://doi.org/10.1161/01.HYP.0000192653.17209.84

The role of SNP-loop diuretic interactions in hypertension across ethnic groups in HyperGEN

L. de las Fuentes, Y. Sung, K. Schwander, et al.. (2013). Frontiers in Genetics. Cited 17 times. https://doi.org/10.3389/fgene.2013.00304

Variants on chromosome 6p22.3 associated with blood pressure in the HyperGEN study: follow-up of FBPP quantitative trait loci.

Jeannette Simino, Gang Shi, D. Arnett, et al.. (2011). American journal of hypertension. Cited 17 times. https://doi.org/10.1038/ajh.2011.140

Meta-analysis of genome-wide linkage scans for renal function traits.

M. Rao, A. Mottl, S. Cole, et al.. (2012). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. Cited 17 times. https://doi.org/10.1093/ndt/gfr255

Sibling Resemblance for Left Ventricular Structure, Contractility, and Diastolic Filling

Weihong Tang, D. Arnett, R. Devereux, et al.. (2002). Hypertension: Journal of the American Heart Association. Cited 17 times. https://doi.org/10.1161/01.HYP.0000028487.62501.12

Refined mapping of suggestive linkage to renal function in African Americans: the HyperGEN study.

A. Dewan, D. Arnett, Michael B. Miller, et al.. (2002). American journal of human genetics. Cited 17 times. https://doi.org/10.1086/340730

Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study

G. de Simone, Weihong Tang, R. Devereux, et al.. (2007). Journal of Hypertension. Cited 16 times. https://doi.org/10.1097/HJH.0b013e328126851e

Linkage of left ventricular early diastolic peak filling velocity to chromosome 5 in hypertensive African Americans: the HyperGEN echocardiography study.

Weihong Tang, D. Arnett, R. Devereux, et al.. (2002). American journal of hypertension. Cited 16 times. https://doi.org/10.1016/S0895-7061(02)02943-6

Genotype Imputation for African Americans Using Data From HapMap Phase II Versus 1000 Genomes Projects

Y. Sung, C. Gu, H. Tiwari, et al.. (2012). Genetic Epidemiology. Cited 15 times. https://doi.org/10.1002/gepi.21647

Racial differences in the association of coronary calcified plaque with left ventricular hypertrophy: the National Heart, Lung, and Blood Institute Family Heart Study and Hypertension Genetic Epidemiology Network.

Weihong Tang, D. Arnett, M. Province, et al.. (2006). The American journal of cardiology. Cited 14 times. https://doi.org/10.1016/J.AMJCARD.2005.11.076

The Role of Rare Variants in Systolic Blood Pressure: Analysis of ExomeChip Data in HyperGEN African Americans

Y. Sung, Jacob J Basson, Nuo Cheng, et al.. (2015). Human Heredity. Cited 11 times. https://doi.org/10.1159/000375373

Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.

Jeannette Simino, Rezart Kume, A. Kraja, et al.. (2014). Atherosclerosis. Cited 11 times. https://doi.org/10.1016/j.atherosclerosis.2014.04.008

Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes

J. Wessel, A. Schork, H. Tiwari, et al.. (2007). Genetic Epidemiology. Cited 11 times. https://doi.org/10.1002/gepi.20241

The Arg16Gly polymorphism of the beta2-adrenergic receptor and left ventricular systolic function.

Weihong Tang, R. Devereux, D. Kitzman, et al.. (2003). American journal of hypertension. Cited 11 times.

Hemodynamic and echocardiographic profiles in African American compared with White offspring of hypertensive parents: the HyperGEN study.

S. Glasser, Amy I. Lynch, R. Devereux, et al.. (2014). American journal of hypertension. Cited 10 times. https://doi.org/10.1093/ajh/hpt178

Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study

N. Wineinger, N. Pajewski, Richard E Kennedy, et al.. (2011). European Journal of Human Genetics. Cited 10 times. https://doi.org/10.1038/ejhg.2011.115

Influence of fat-free mass on detection of appropriateness of left ventricular mass: the HyperGEN Study

G. Simone, R. B. Devereux, V. Palmieri, et al.. (2003). Journal of Hypertension. Cited 10 times. https://doi.org/10.1097/00004872-200309000-00025

Genome‐wide survey in African Americans demonstrates potential epistasis of fitness in the human genome

Heming Wang, Yoonha Choi, B. Tayo, et al.. (2017). Genetic Epidemiology. Cited 9 times. https://doi.org/10.1002/gepi.22026

Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study

Amy I. Lynch, D. Arnett, J. Pankow, et al.. (2007). Human Genetics. Cited 9 times. https://doi.org/10.1007/s00439-007-0370-y

Enhanced genetic maps from family-based disease studies: population-specific comparisons

Chunsheng He, D. Weeks, S. Buyske, et al.. (2011). BMC Medical Genetics. Cited 8 times. https://doi.org/10.1186/1471-2350-12-15

Subclinical, hemodynamic, and echocardiographic abnormalities of high pulse pressure in hypertensive and non-hypertensive adults.

S. Glasser, Tatiana Krasikov, R. Devereux, et al.. (2012). American journal of cardiovascular disease. Cited 6 times.

Partial normalization of components of metabolic syndrome does not influence prevalent echocardiographic abnormalities: the HyperGEN study.

G. Simone, D. Arnett, M. Chinali, et al.. (2013). Nutrition, metabolism, and cardiovascular diseases : NMCD. Cited 4 times. https://doi.org/10.1016/j.numecd.2011.02.004

A genome scan for linkage with aortic root diameter in hypertensive African Americans and whites in the Hypertension Genetic Epidemiology Network (HyperGEN) study.

Amy I. Lynch, D. Arnett, L. Atwood, et al.. (2005). American journal of hypertension. Cited 4 times. https://doi.org/10.1016/J.AMJHYPER.2004.11.029

Adducin 1 (alpha) Gly460Trp variant is associated with left ventricular geometry in Caucasians and African Americans: The HyperGEN Study.

K. Chauhan, R. Devereux, D. Rao, et al.. (2010). International journal of molecular epidemiology and genetics. Cited 1 times.