<p>Psoriasis is a common immune-mediate disease identified through scaly patches of the skin. In this study we collected genotype information on 5,067 samples of European ancestry as a follow-up study of our initial GWAS (<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=19169254">Nair et al. 2009</a>). We designed an Illumina iSelect custom genotyping array with 2,269 tagging SNPs in the eight known psoriasis susceptibility regions (<a href="https://www.ncbi.nlm.nih.gov/gene/3107">MHC</a>, <a href="https://www.ncbi.nlm.nih.gov/gene/3593">IL12B</a>, <a href="https://www.ncbi.nlm.nih.gov/gene/149233">IL23R</a>, <a href="https://www.ncbi.nlm.nih.gov/gene/51561">IL23A</a>, <a href="https://www.ncbi.nlm.nih.gov/gene/7128">TNFAIP3</a>, <a href="https://www.ncbi.nlm.nih.gov/gene/3596">IL13</a>, <a href="https://www.ncbi.nlm.nih.gov/gene/55905">RNF114</a>, and <a href="https://www.ncbi.nlm.nih.gov/gene/10318">TNIP1</a>). The custom array also included 5,463 SNPs outside the eight known susceptibility regions, which were selected based on their association p-values in a meta-analysis of HapMap-imputed genotypes of two published GWAS-CASP (<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=19169254">Nair et al. 2009</a>) and (<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=20953188">Ellinghaus et al. 2010</a>). After quality control we analyzed 4,806 samples (2,699 cases and 2,107 controls). </p> <p>Please note: The accession number for this dbGaP study was incorrectly listed in the relevant publication (<a href="https://www.ncbi.nlm.nih.gov/pubmed/25182136">Das et al.</a>, 2015, Eur. J. Hum. Genet 23:844-853) as phs000019.v1.p1.</p>

Fine Mapping of Eight Psoriasis Susceptibility Loci

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