NHLBI TOPMed: GOLDN Epigenetic Determinants of Lipid Response to Dietary Fat and Fenofibrate

Mixed linear model approach adapted for genome-wide association studies

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CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids.

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Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference

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APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations.

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Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study

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SNPs located at CpG sites modulate genome-epigenome interaction

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The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study.

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A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.

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Enrichment of statistical power for genome-wide association studies

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Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study

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Nutrigenomics in Cardiovascular Medicine

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Effect of influenza vaccine on markers of inflammation and lipid profile.

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Association between the APOA2 promoter polymorphism and body-weight in Mediterranean and Asian populations. Replication of a gene-saturated fat interaction

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Profiling Circulating and Urinary Bile Acids in Patients with Biliary Obstruction before and after Biliary Stenting

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Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population)

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ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study

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Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

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High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an interventional study

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Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.

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Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.

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Saturated fat intake modulates the association between an obesity genetic risk score and body mass index in two US populations.

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Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention.

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Impact of genetic and environmental factors on hsCRP concentrations and response to therapeutic agents.

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A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.

Yu-Chi Lee, Chao-Qiang Lai, J. Ordovás, et al.. (2011). Journal of data mining in genomics & proteomics. Cited 73 times. https://doi.org/10.4172/2153-0602.1000106

Methylation at CPT1A locus is associated with lipoprotein subfraction profiles[S]

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Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study

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Nutrition in the genomics era: cardiovascular disease risk and the Mediterranean diet.

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Genotype–Phenotype Associations: Modulation by Diet and Obesity

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Erythrocyte fatty acid composition and the metabolic syndrome: a National Heart, Lung, and Blood Institute GOLDN study.

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Profile of serum bile acids in non-cholestatic volunteers: gender-related differences in response to fenofibrate

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Review and Evaluation of Methods Correcting for Population Stratification with a Focus on Underlying Statistical Principles

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A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network

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The PLIN4 Variant rs8887 Modulates Obesity Related Phenotypes in Humans through Creation of a Novel miR-522 Seed Site

K. Richardson, Qiong Louie-Gao, D. Arnett, et al.. (2011). PLoS ONE. Cited 61 times. https://doi.org/10.1371/journal.pone.0017944

CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American

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Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia.

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Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits

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Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants and response to fenofibrate

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Why study gene–environment interactions?

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Comparison of ultracentrifugation and nuclear magnetic resonance spectroscopy in the quantification of triglyceride-rich lipoproteins after an oral fat load.

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Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.

P. Pérez-Martínez, D. Corella, Jian Shen, et al.. (2009). The American journal of clinical nutrition. Cited 48 times. https://doi.org/10.3945/ajcn.2008.26363

REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.

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The PPAR Alpha gene is associated with triglyceride, low-density cholesterol, and inflammation marker response to fenofibrate intervention: The GOLDN Study

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Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the Genetics of Lipid-Lowering Drugs and Diet Network study

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Genome-Wide Contribution of Genotype by Environment Interaction to Variation of Diabetes-Related Traits

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Genetic Analysis of 16 NMR-Lipoprotein Fractions in Humans, the GOLDN Study

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Association of Common C-Reactive Protein (CRP) Gene Polymorphisms With Baseline Plasma CRP Levels and Fenofibrate Response

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Apolipoprotein E Polymorphisms and Postprandial Triglyceridemia Before and After Fenofibrate Treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study

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Clinical significance of apolipoprotein A5

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Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.

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The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter.

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Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study

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Fenofibrate and metabolic syndrome.

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Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge

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Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study.

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Smoking, inflammatory patterns and postprandial hypertriglyceridemia.

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Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.

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Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity

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Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study[S]

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Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate

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The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions

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Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN).

M. Wojczynski, L. Parnell, T. Pollin, et al.. (2015). Metabolism: clinical and experimental. Cited 35 times. https://doi.org/10.1016/j.metabol.2015.07.001

ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study.

M. Junyent, L. Parnell, C-Q Lai, et al.. (2010). Nutrition, metabolism, and cardiovascular diseases : NMCD. Cited 35 times. https://doi.org/10.1016/j.numecd.2009.06.011

Clustering by Plasma Lipoprotein Profile Reveals Two Distinct Subgroups with Positive Lipid Response to Fenofibrate Therapy

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WDTC1, the Ortholog of Drosophila Adipose Gene, Associates With Human Obesity, Modulated by MUFA Intake

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A Powerful Test of Parent-of-Origin Effects for Quantitative Traits Using Haplotypes

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The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment

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Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis

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Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations.

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Dietary Patterns, Genes, and Health: Challenges and Obstacles to be Overcome

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Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations.

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Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.

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Modulation by Dietary Fat and Carbohydrate of IRS1 Association With Type 2 Diabetes Traits in Two Populations of Different Ancestries

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Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.

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Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome.

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Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36[S]

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Assessment of postprandial triglycerides in clinical practice: Validation in a general population and coronary heart disease patients.

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Epigenetics Lights Up the Obesity Field

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Genomics of Post-Prandial Lipidomic Phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study

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Clinical applications of epigenetics in cardiovascular disease: the long road ahead.

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Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

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Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet Network.

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Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature.

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A clustering analysis of lipoprotein diameters in the metabolic syndrome

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Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women.

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Determination of Fenofibric Acid Concentrations by HPLC After Anion Exchange Solid-Phase Extraction From Human Serum

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Lipid changes due to fenofibrate treatment are not associated with changes in DNA methylation patterns in the GOLDN study

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Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance.

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Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.

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Cholesterol, Inflammasomes, and Atherogenesis

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Opportunities for Using Lipoprotein Subclass Profile by Nuclear Magnetic Resonance Spectroscopy in Assessing Insulin Resistance and Diabetes Prediction

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A data‐driven method for identifying rare variants with heterogeneous trait effects

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Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects

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The Effect of CYP7A1 Polymorphisms on Lipid Responses to Fenofibrate

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