<p>Serial whole exome sequencing of samples collected from 21 patients at multiple time points during progression from early to late chronic lymphocytic leukemia (CLL) and one matching non-tumor tissue sample from each patient. Additional whole genome sequencing of samples from 3 selected patients.</p> <p>Genome-wide B cell methylation compared between 5 healthy donors from the same age group as patients, 20 patients with monoclonal B cell lymphocytosis and in serial CLL samples with matching whole exome sequencing. Moreover, genome-wide single-cell RRBS-profiling of B cells from one healthy donor and from one patient with CLL was performed using a protocol newly developed by the A. Meissner group.</p>

Whole Exome and Whole Genome Profiling as well Genome-Wide Methylation    Profiling from Early to Advanced Chronic Lymphocytic leukemia (CLL),    Genome-Wide Methylation Profiling in Monoclonal B Cell Lymphocytosis    (MBL)

14 variables across Demographics, Race and Ethnicity

Variables — phs001431 — Whole Exome and Whole Genome Profiling as well Genome-Wide Methylation    Profiling from Early to Advanced Chronic Lymphocytic leukemia (CLL),    Genome-Wide Methylation Profiling in Monoclonal B Cell Lymphocytosis    (MBL)

Whole Exome and Whole Genome Profiling as well Genome-Wide Methylation Profiling from Early to Advanced Chronic Lymphocytic leukemia (CLL), Genome-Wide Methylation Profiling in Monoclonal B Cell Lymphocytosis (MBL)

Demographics (2)

Race and Ethnicity (1)

Other (11)