Deep Sequencing Studies for Cannabis and Stimulant Dependence

GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation

Dongjun Chung, Can Yang, Cong Li, et al.. (2014). PLoS Genetics. Cited 210 times. https://doi.org/10.1371/journal.pgen.1004787

The genetics of addiction—a translational perspective

A. Agrawal, K. Verweij, K. Verweij, et al.. (2012). Translational Psychiatry. Cited 185 times. https://doi.org/10.1038/tp.2012.54

Variant Callers for Next-Generation Sequencing Data: A Comparison Study

Xiangtao Liu, Shizhong Han, Zuoheng Wang, et al.. (2013). PLoS ONE. Cited 171 times. https://doi.org/10.1371/journal.pone.0075619

An informatics approach to analyzing the incidentalome

J. Berg, Michael C. Adams, Nassib Nassar, et al.. (2012). Genetics in Medicine. Cited 169 times. https://doi.org/10.1038/gim.2012.112

Measuring historical trauma in an American Indian community sample: contributions of substance dependence, affective disorder, conduct disorder and PTSD.

C. Ehlers, I. Gizer, D. Gilder, et al.. (2013). Drug and alcohol dependence. Cited 108 times. https://doi.org/10.1016/j.drugalcdep.2013.05.011

Association of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use Disorder

Dawei Li, Arvis Sulovari, Chao Cheng, et al.. (2014). Neuropsychopharmacology. Cited 88 times. https://doi.org/10.1038/npp.2013.291

Improving genetic risk prediction by leveraging pleiotropy

Cong Li, Can Yang, J. Gelernter, et al.. (2013). Human Genetics. Cited 79 times. https://doi.org/10.1007/s00439-013-1401-5

A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans

K. Jensen, E. DeVito, A. Herman, et al.. (2015). Neuropsychopharmacology. Cited 72 times. https://doi.org/10.1038/npp.2015.131

Evidence for the role of EPHX2 gene variants in anorexia nervosa

A. S. Zeeland, C. Bloss, R. Tewhey, et al.. (2013). Molecular Psychiatry. Cited 71 times. https://doi.org/10.1038/mp.2013.91

Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS

Qian Wang, Can Yang, J. Gelernter, et al.. (2015). Human Genetics. Cited 70 times. https://doi.org/10.1007/s00439-015-1596-8

Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD.

C. Ehlers, I. Gizer, D. Gilder, et al.. (2013). Journal of psychiatric research. Cited 69 times. https://doi.org/10.1016/j.jpsychires.2012.10.002

Evidence for a genetic component for substance dependence in Native Americans.

C. Ehlers, I. Gizer. (2013). The American journal of psychiatry. Cited 67 times. https://doi.org/10.1176/appi.ajp.2012.12010113

Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence

Pingxing Xie, H. Kranzler, M. Krauthammer, et al.. (2011). Biological Psychiatry. Cited 67 times. https://doi.org/10.1016/j.biopsych.2011.04.017

Omics Pipe: a community-based framework for reproducible multi-omics data analysis

K. Fisch, T. Meissner, Louis Gioia, et al.. (2015). Bioinformatics. Cited 65 times. https://doi.org/10.1093/bioinformatics/btv061

ADH and ALDH Polymorphisms and Alcohol Dependence in Mexican and Native Americans

C. Ehlers, Tiebing Liang, I. Gizer. (2012). The American Journal of Drug and Alcohol Abuse. Cited 62 times. https://doi.org/10.3109/00952990.2012.694526

Whole Genome Sequences of a Male and Female Supercentenarian, Ages Greater than 114 Years

P. Sebastiani, A. Riva, M. Montano, et al.. (2012). Frontiers in Genetics. Cited 61 times. https://doi.org/10.3389/fgene.2011.00090

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans

Trygve E Bakken, J. Roddey, S. Djurovic, et al.. (2012). Proceedings of the National Academy of Sciences. Cited 55 times. https://doi.org/10.1073/pnas.1105829109

Multi-Cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder

Jian Cao, J. Hudziak, Dawei Li. (2013). Neuropsychopharmacology. Cited 49 times. https://doi.org/10.1038/npp.2013.73

Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans

Shizhong Han, Bao-Zhu Yang, H. Kranzler, et al.. (2012). Biological Psychiatry. Cited 42 times. https://doi.org/10.1016/j.biopsych.2012.02.038

Variant calling in low-coverage whole genome sequencing of a Native American population sample

C. Bizon, M. Spiegel, S. Chasse, et al.. (2014). BMC Genomics. Cited 38 times. https://doi.org/10.1186/1471-2164-15-85

High Diagnostic Yield of Whole Exome Sequencing in Participants With Retinal Dystrophies in a Clinical Ophthalmology Setting.

Kristy Lee, J. Berg, Laura V. Milko, et al.. (2015). American journal of ophthalmology. Cited 37 times. https://doi.org/10.1016/j.ajo.2015.04.026

Assessing group differences in biodiversity by simultaneously testing a user‐defined selection of diversity indices

Philip Pallmann, F. Schaarschmidt, L. Hothorn, et al.. (2012). Molecular Ecology Resources. Cited 37 times. https://doi.org/10.1111/1755-0998.12004

Multi-view singular value decomposition for disease subtyping and genetic associations

Jiangwen Sun, J. Bi, H. Kranzler. (2014). BMC Genetics. Cited 34 times. https://doi.org/10.1186/1471-2156-15-73

A Weighted Polygenic Risk Score Using 14 Known Susceptibility Variants to Estimate Risk and Age Onset of Psoriasis in Han Chinese

X. Yin, Hui Cheng, Yan Lin, et al.. (2015). PLoS ONE. Cited 28 times. https://doi.org/10.1371/journal.pone.0125369

Empirically derived subtypes of opioid use and related behaviors.

G. Chan, J. Gelernter, D. Oslin, et al.. (2011). Addiction. Cited 27 times. https://doi.org/10.1111/j.1360-0443.2011.03390.x

Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.

Whitney E. Melroy-Greif, K. Wilhelmsen, C. Ehlers. (2016). Drug and alcohol dependence. Cited 26 times. https://doi.org/10.1016/j.drugalcdep.2016.06.021

Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol‐related phenotypes in a Native American community sample

Qian Peng, I. Gizer, Ondrej Libiger, et al.. (2014). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Cited 26 times. https://doi.org/10.1002/ajmg.b.32272

Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study.

I. Gizer, C. Ehlers, C. Vieten, et al.. (2011). Drug and alcohol dependence. Cited 25 times. https://doi.org/10.1016/j.drugalcdep.2010.07.017

Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence

Pingxing Xie, H. Kranzler, J. Krystal, et al.. (2014). Addiction Biology. Cited 24 times. https://doi.org/10.1111/adb.12072

Item response theory analysis of binge drinking and its relationship to lifetime alcohol use disorder symptom severity in an American Indian community sample.

D. Gilder, I. Gizer, C. Ehlers. (2011). Alcoholism, clinical and experimental research. Cited 24 times. https://doi.org/10.1111/j.1530-0277.2010.01429.x

The clinical course of DSM-5 alcohol use disorders in young adult native and Mexican Americans.

C. Ehlers, Gina M. Stouffer, L. Corey, et al.. (2015). The American journal on addictions. Cited 23 times. https://doi.org/10.1111/ajad.12290

ReQON: a Bioconductor package for recalibrating quality scores from next-generation sequencing data

Christopher R. Cabanski, Keary Cavin, C. Bizon, et al.. (2012). BMC Bioinformatics. Cited 23 times. https://doi.org/10.1186/1471-2105-13-221

Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population.

X. Yin, Nathan E. Wineinger, W. Yue, et al.. (2016). Journal of psychiatry & neuroscience : JPN. Cited 22 times. https://doi.org/10.1503/JPN.150210

DISSCO: direct imputation of summary statistics allowing covariates

Zheng Xu, Qing Duan, Song Yan, et al.. (2015). Bioinformatics. Cited 21 times. https://doi.org/10.1093/bioinformatics/btv168

Depression symptoms associated with cannabis dependence in an adolescent American Indian community sample.

D. Gilder, C. Ehlers. (2012). The American journal on addictions. Cited 21 times. https://doi.org/10.1111/j.1521-0391.2012.00281.x

Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants

Can Yang, Cong Li, H. Kranzler, et al.. (2014). Human Genetics. Cited 20 times. https://doi.org/10.1007/s00439-013-1399-8

Linkage analyses of stimulant dependence, craving, and heavy use in American Indians

C. Ehlers, I. Gizer, D. Gilder, et al.. (2011). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Cited 19 times. https://doi.org/10.1002/ajmg.b.31218

Conservation of Distinct Genetically-Mediated Human Cortical Pattern

Qian Peng, A. Schork, H. Bartsch, et al.. (2016). PLoS Genetics. Cited 18 times. https://doi.org/10.1371/journal.pgen.1006143

FKBP5 variation is associated with the acute and chronic effects of nicotine

Kevin P. Jensen, A. Herman, M. Morean, et al.. (2014). The Pharmacogenomics Journal. Cited 18 times. https://doi.org/10.1038/tpj.2014.76

Associations between a history of binge drinking during adolescence and self-reported responses to alcohol in young adult Native and Mexican Americans.

C. Ehlers, Gina M. Stouffer, D. Gilder. (2014). Alcoholism, clinical and experimental research. Cited 18 times. https://doi.org/10.1111/acer.12466

Correlation analysis of genetic admixture and social identification with body mass index in a Native American Community

Trina M. Norden-Krichmar, I. Gizer, Ondrej Libiger, et al.. (2014). American Journal of Human Biology. Cited 18 times. https://doi.org/10.1002/ajhb.22521

Genome-Wide Association Study of Post-Traumatic Stress Disorder in Two High-Risk Populations

Whitney E. Melroy-Greif, K. Wilhelmsen, R. Yehuda, et al.. (2017). Twin Research and Human Genetics. Cited 17 times. https://doi.org/10.1017/thg.2017.12

Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions

Qian Wang, R. Polimanti, H. Kranzler, et al.. (2016). Human Genetics. Cited 17 times. https://doi.org/10.1007/s00439-016-1737-8

Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans

Shizhong Han, J. Gelernter, H. Kranzler, et al.. (2013). Human Genetics. Cited 17 times. https://doi.org/10.1007/s00439-012-1255-2

Single nucleotide polymorphisms in the REG‐CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample

C. Ehlers, I. Gizer, C. Bizon, et al.. (2016). Genes. Cited 16 times. https://doi.org/10.1111/gbb.12297

Protective variant associated with alcohol dependence in a Mexican American cohort

Trina M. Norden-Krichmar, I. Gizer, K. Wilhelmsen, et al.. (2014). BMC Medical Genetics. Cited 15 times. https://doi.org/10.1186/s12881-014-0136-z

Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population.

Jacqueline M. Otto, I. Gizer, C. Bizon, et al.. (2016). Drug and alcohol dependence. Cited 14 times. https://doi.org/10.1016/j.drugalcdep.2016.07.029

A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke

K. Jensen, Andrew H Smith, A. Herman, et al.. (2017). Molecular Psychiatry. Cited 14 times. https://doi.org/10.1038/mp.2016.43

Can Genetic Analysis of Putative Blood Alzheimer’s Disease Biomarkers Lead to Identification of Susceptibility Loci?

R. Barber, N. Phillips, J. Tilson, et al.. (2015). PLoS ONE. Cited 13 times. https://doi.org/10.1371/journal.pone.0142360

CHRNA5 and CHRNA3 Variants and Level of Neuroticism in Young Adult Mexican American Men and Women

J. Criado, I. Gizer, H. Edenberg, et al.. (2014). Twin Research and Human Genetics. Cited 13 times. https://doi.org/10.1017/thg.2014.11

Item response theory analyses of DSM-IV and DSM-5 stimulant use disorder criteria in an American Indian community sample.

D. Gilder, I. Gizer, Philip Lau, et al.. (2014). Drug and alcohol dependence. Cited 13 times. https://doi.org/10.1016/j.drugalcdep.2013.10.010

Group-based variant calling leveraging next-generation supercomputing for large-scale whole-genome sequencing studies

K. Standish, Tristan M. Carland, Glenn K. Lockwood, et al.. (2015). BMC Bioinformatics. Cited 12 times. https://doi.org/10.1186/s12859-015-0736-4

Chip-based direct genotyping of coding variants in genome wide association studies: utility, issues and prospects.

C. Nievergelt, N. Wineinger, Ondrej Libiger, et al.. (2014). Gene. Cited 12 times. https://doi.org/10.1016/j.gene.2014.01.069

A New Framework and Prototype Solution for Clinical Decision Support and Research in Genomics and Other Data-intensive Fields of Medicine

J. Evans, K. Wilhelmsen, J. Berg, et al.. (2016). eGEMs. Cited 10 times. https://doi.org/10.13063/2327-9214.1198

Contributions of ethnicity to differential item functioning of cannabis abuse and dependence symptoms.

I. Gizer, D. Gilder, Philip Lau, et al.. (2013). Journal of studies on alcohol and drugs. Cited 10 times. https://doi.org/10.15288/JSAD.2013.74.320

Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample.

D. Gilder, Gina M. Stouffer, Philip Lau, et al.. (2016). Drug and alcohol dependence. Cited 9 times. https://doi.org/10.1016/j.drugalcdep.2016.02.006

Obesity in American Indian and Mexican American Men and Women: Associations with Blood Pressure and Cardiovascular Autonomic Control

J. Criado, D. Gilder, M. Kalafut, et al.. (2013). Cardiovascular Psychiatry and Neurology. Cited 9 times. https://doi.org/10.1155/2013/680687

Stimulant Dependence and Stimulant-Associated Psychosis: Clinical Characteristics and Age of Onset in a Native American Community Sample

D. Gilder, I. Gizer, Philip Lau, et al.. (2014). Journal of Addiction Medicine. Cited 8 times. https://doi.org/10.1097/ADM.0000000000000039

Partial Least Squares Regression Can Aid in Detecting Differential Abundance of Multiple Features in Sets of Metagenomic Samples

Ondrej Libiger, N. Schork. (2015). Frontiers in Genetics. Cited 7 times. https://doi.org/10.3389/fgene.2015.00350

Molecular genetic approaches to understanding the comorbidity of psychiatric disorders

I. Gizer. (2016). Development and Psychopathology. Cited 6 times. https://doi.org/10.1017/S0954579416000717

Refining multivariate disease phenotypes for high chip heritability

Jiangwen Sun, H. Kranzler, J. Bi. (2015). BMC Medical Genomics. Cited 6 times. https://doi.org/10.1186/1755-8794-8-S3-S3

Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study

I. Gizer, C. Ehlers, C. Vieten, et al.. (2012). Psychiatric Genetics. Cited 6 times. https://doi.org/10.1097/YPG.0b013e328353fb77

Event-related oscillations to affective stimuli: heritability, linkage and relationship to externalizing disorders.

J. Criado, I. Gizer, W. Slutske, et al.. (2012). Journal of psychiatric research. Cited 5 times. https://doi.org/10.1016/j.jpsychires.2011.10.017

Whole genome sequence association and ancestry‐informed polygenic profile of EEG alpha in a Native American population

Qian Peng, N. Schork, K. Wilhelmsen, et al.. (2017). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Cited 4 times. https://doi.org/10.1002/ajmg.b.32533

Association Studies with Imputed Variants Using Expectation-Maximization Likelihood-Ratio Tests

(2014). PLoS ONE. Cited 3 times. https://doi.org/10.1371/journal.pone.0110679

Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort

Trina M. Norden-Krichmar, I. Gizer, E. Phillips, et al.. (2015). Twin Research and Human Genetics. Cited 2 times. https://doi.org/10.1017/thg.2015.77