Studies
Somatic Mutations and Cell Lineage in the Human Brain
Somatic Mutations and Cell Lineage in the Human Brain
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Overview
Selected Publications (12)
Aging and neurodegeneration are associated with increased mutations in single human neurons
Michael A. Lodato, Rachel E. Rodin, Craig L. Bohrson, et al.. (2017). Science. Cited 566 times.
https://doi.org/10.1126/science.aao4426
Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain
Gilad D. Evrony, Xuyu Cai, E. Lee, et al.. (2012). Cell. Cited 529 times.
https://doi.org/10.1016/j.cell.2012.09.035
Somatic mutation in single human neurons tracks developmental and transcriptional history
Michael A. Lodato, Mollie B. Woodworth, Semin Lee, et al.. (2015). Science. Cited 521 times.
https://doi.org/10.1126/science.aab1785
Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain
Xuyu Cai, Gilad D. Evrony, Hillel S. Lehmann, et al.. (2014). Cell reports. Cited 265 times.
https://doi.org/10.1016/j.celrep.2014.07.043
Building a lineage from single cells: genetic techniques for cell lineage tracking
Mollie B. Woodworth, Kelly M. Girskis, C. Walsh. (2017). Nature Reviews Genetics. Cited 230 times.
https://doi.org/10.1038/nrg.2016.159
Resolving rates of mutation in the brain using single-neuron genomics
Gilad D. Evrony, E. Lee, P. Park, et al.. (2016). eLife. Cited 153 times.
https://doi.org/10.7554/eLife.12966
Landmarks of human embryonic development inscribed in somatic mutations
S. Bizzotto, Yanmei Dou, J. Ganz, et al.. (2021). Science. Cited 93 times.
https://doi.org/10.1126/science.abe1544
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
Lovelace J. Luquette, Michael B. Miller, Zinan Zhou, et al.. (2022). Nature Genetics. Cited 72 times.
https://doi.org/10.1038/s41588-022-01180-2
Accurate detection of mosaic variants in sequencing data without matched controls
Yanmei Dou, Minseok Kwon, Rachel E. Rodin, et al.. (2019). Nature biotechnology. Cited 67 times.
https://doi.org/10.1038/s41587-019-0368-8
Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms.
Michael A. Lodato, C. Walsh. (2019). Human molecular genetics. Cited 39 times.
https://doi.org/10.1093/hmg/ddz191
Somatic Mutation in Pediatric Neurological Diseases.
Rachel E. Rodin, C. Walsh. (2018). Pediatric neurology. Cited 19 times.
https://doi.org/10.1016/j.pediatrneurol.2018.08.008
PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation
Maxwell A. Sherman, Alison R. Barton, Michael A. Lodato, et al.. (2017). Nucleic Acids Research. Cited 12 times.
https://doi.org/10.1101/166637
