This is a study of the biological risk factors for children enrolled in <a href="https://hhd.psu.edu/nutrition/insight-study">the INSIGHT (Intervention Nurses Start Infants Growing on Healthy Trajectories) study</a>. INSIGHT is a randomized, controlled trial testing a responsive parenting intervention designed for the primary prevention of childhood obesity against a safety control. These first-born children were deeply studied in this time period with data collected on a wide variety of variables including mode of delivery, gender, weight and height (collected at 7 time points), medication usage, diet information, and maternal health information (gestational weight gain, gestational diabetes, smoking during pregnancy). This study includes a survey of the oral and gut microbiota from 226 mother-child dyads. It was designed to investigate the relationship between a cross-sectional view of the child's microbiome (at two years of age) and the patterns of growth between birth and 2 years. Microbiome samples from children (buccal swab and stool sample) and their mothers (buccal swab) are collected at the children's 2-year clinical research visit. Stool metabolites have also been assayed for a subset of the 226 children using 1H-NMR. Additionally, we genotyped the same individuals for SNPs across the genome. For a subset of 48 individuals we have added second-born siblings. For these additional 48 children, we characterized the methylation pattern across the genome using cord blood and placenta samples.

INSIGHT (Intervention Nurses Start Infants Growing on Healthy Trajectories) Cohort

The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study

Child Weight Gain Trajectories Linked To Oral Microbiota Composition

Metabolomic profiling of stool of two‐year old children from the INSIGHT study reveals links between butyrate and child weight outcomes

Constructing a polygenic risk score for childhood obesity using functional data analysis

Methylation profiles at birth linked to early childhood obesity