NHLBI TOPMed: Genetics of Asthma in Latino Americans (GALA)

Request Access

An integrated map of genetic variation from 1,092 human genomes

Gil A. David M. Richard M. Gonçalo R. David R. Aravind McVean Altshuler (Co-Chair) Durbin (Co-Chair) Abec, Gil A. McVean, David M. Richard M. Gonçalo R. David R. Aravinda Andrew Altshuler (Co-Chair) Durbin (Co-Chair) Abecasis Be, et al.. (2012). Nature. Cited 7,953 times. https://doi.org/10.1038/nature11632

Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations

D. Torgerson, E. Ampleford, Grace Y. Chiu, et al.. (2011). Nature genetics. Cited 821 times. https://doi.org/10.1038/ng.888

The genetics of Mexico recapitulates Native American substructure and affects biomedical traits

A. Moreno-Estrada, Christopher R. Gignoux, J. Fernández-López, et al.. (2014). Science. Cited 481 times. https://doi.org/10.1126/science.1251688

ORMDL3 gene is associated with asthma in three ethnically diverse populations.

J. Galanter, S. Choudhry, C. Eng, et al.. (2008). American journal of respiratory and critical care medicine. Cited 260 times. https://doi.org/10.1164/rccm.200711-1644OC

Population stratification confounds genetic association studies among Latinos

S. Choudhry, N. Coyle, Hua Tang, et al.. (2005). Human Genetics. Cited 238 times. https://doi.org/10.1007/s00439-005-0071-3

Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas

J. Galanter, J. Fernández-López, Christopher R. Gignoux, et al.. (2012). PLoS Genetics. Cited 237 times. https://doi.org/10.1371/journal.pgen.1002554

Genetic ancestry in lung-function predictions.

R. Kumar, M. Seibold, M. Aldrich, et al.. (2010). The New England journal of medicine. Cited 235 times. https://doi.org/10.1056/NEJMoa0907897

Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.

S. Choudhry, N. Ung, P. Avila, et al.. (2005). American journal of respiratory and critical care medicine. Cited 233 times. https://doi.org/10.1164/RCCM.200409-1286OC

Fast and accurate inference of local ancestry in Latino populations

Yael Baran, Bogdan Pasaniuc, S. Sankararaman, et al.. (2012). Bioinformatics. Cited 229 times. https://doi.org/10.1093/bioinformatics/bts144

Genetic admixture and asthma‐related phenotypes in Mexican American and Puerto Rican asthmatics

K. Salari, S. Choudhry, Hua Tang, et al.. (2005). Genetic Epidemiology. Cited 190 times. https://doi.org/10.1002/GEPI.20079

Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma.

E. Burchard, P. Avila, S. Nazario, et al.. (2004). American journal of respiratory and critical care medicine. Cited 180 times. https://doi.org/10.1164/RCCM.200309-1293OC

Recent genetic selection in the ancestral admixture of Puerto Ricans.

Hua Tang, S. Choudhry, R. Mei, et al.. (2007). American journal of human genetics. Cited 176 times. https://doi.org/10.1086/520769

Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children

D. Hancock, I. Romieu, M. Shi, et al.. (2009). PLoS Genetics. Cited 158 times. https://doi.org/10.1371/journal.pgen.1000623

ADAM33 is not associated with asthma in Puerto Rican or Mexican populations.

D. Lind, S. Choudhry, N. Ung, et al.. (2003). American journal of respiratory and critical care medicine. Cited 143 times. https://doi.org/10.1164/RCCM.200306-877OC

Genome-wide association analysis identifies six new loci associated with forced vital capacity

D. Loth, M. Artigas, S. Gharib, et al.. (2014). Nature Genetics. Cited 143 times. https://doi.org/10.1038/ng.3011

Genetic ancestry and risk of breast cancer among U.S. Latinas.

L. Fejerman, E. John, S. Huntsman, et al.. (2008). Cancer research. Cited 122 times. https://doi.org/10.1158/0008-5472.CAN-08-2039

CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma.

S. Choudhry, P. Avila, S. Nazario, et al.. (2005). American journal of respiratory and critical care medicine. Cited 112 times. https://doi.org/10.1164/RCCM.200409-1232OC

A genome-wide association study of bronchodilator response in Latinos implicates rare variants.

Katherine A. Drake, D. Torgerson, Christopher R. Gignoux, et al.. (2014). The Journal of allergy and clinical immunology. Cited 109 times. https://doi.org/10.1016/j.jaci.2013.06.043

Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations

H. Tsai, S. Choudhry, M. Naqvi, et al.. (2005). Human Genetics. Cited 106 times. https://doi.org/10.1007/s00439-005-0067-z

Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.

M. Seibold, Samantha M. Donnelly, M. Solon, et al.. (2008). The Journal of allergy and clinical immunology. Cited 102 times. https://doi.org/10.1016/j.jaci.2008.08.023

Ethnic-Specific Differences in Bronchodilator Responsiveness Among African Americans, Puerto Ricans, and Mexicans with Asthma

M. Naqvi, J. Rodriguez-Santana. (2007). Journal of Asthma. Cited 78 times. https://doi.org/10.1080/02770900701554441

Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region

S. Choudhry, M. Taub, R. Mei, et al.. (2008). Human Genetics. Cited 77 times. https://doi.org/10.1007/s00439-008-0495-7

Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthma.

M. Naqvi, S. Choudhry, H. Tsai, et al.. (2007). The Journal of allergy and clinical immunology. Cited 73 times. https://doi.org/10.1016/J.JACI.2007.02.045

Ancestry-environment interactions and asthma risk among Puerto Ricans.

S. Choudhry, E. Burchard, L. Borrell, et al.. (2006). American journal of respiratory and critical care medicine. Cited 70 times. https://doi.org/10.1164/RCCM.200605-596OC

Race, ethnicity and social class and the complex etiologies of asthma.

Katherine A. Drake, J. Galanter, E. Burchard. (2008). Pharmacogenomics. Cited 70 times. https://doi.org/10.2217/14622416.9.4.453

Differences in allergic sensitization by self-reported race and genetic ancestry.

James J. Yang, E. Burchard, S. Choudhry, et al.. (2008). The Journal of allergy and clinical immunology. Cited 63 times. https://doi.org/10.1016/j.jaci.2008.07.044

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos.

M. Pino-Yanes, M. Pino-Yanes, Christopher R. Gignoux, et al.. (2015). The Journal of allergy and clinical immunology. Cited 57 times. https://doi.org/10.1016/j.jaci.2014.10.033

GSNO reductase and β2-adrenergic receptor gene–gene interaction: bronchodilator responsiveness to albuterol

S. Choudhry, L. Que, Zhonghui Yang, et al.. (2010). Pharmacogenetics and Genomics. Cited 55 times. https://doi.org/10.1097/FPC.0b013e328337f992

Case-control admixture mapping in Latino populations enriches for known asthma-associated genes.

D. Torgerson, Christopher R. Gignoux, J. Galanter, et al.. (2012). The Journal of allergy and clinical immunology. Cited 55 times. https://doi.org/10.1016/j.jaci.2012.02.040

Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations

Hui-Ju Tsai, Hui-Ju Tsai, Jennifer Kho, et al.. (2005). Human Genetics. Cited 49 times. https://doi.org/10.1007/s00439-005-0080-2

Relationship between recent short-acting beta-agonist use and subsequent asthma exacerbations.

J. Paris, E. Peterson, K. Wells, et al.. (2008). Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. Cited 49 times. https://doi.org/10.1016/S1081-1206(10)60286-4

Genetic ancestry modifies pharmacogenetic gene–gene interaction for asthma

H. Corvol, Anthony F. De Giacomo, C. Eng, et al.. (2009). Pharmacogenetics and Genomics. Cited 46 times. https://doi.org/10.1097/FPC.0b013e32832c440e

Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation

Bogdan Pasaniuc, S. Sankararaman, D. Torgerson, et al.. (2013). Bioinformatics. Cited 42 times. https://doi.org/10.1093/bioinformatics/btt166

Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients.

Ying Jin, Ying Jin, D. Hu, et al.. (2010). The Journal of allergy and clinical immunology. Cited 38 times. https://doi.org/10.1016/j.jaci.2010.06.007

Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations.

J. Galanter, D. Torgerson, Christopher R. Gignoux, et al.. (2011). The Journal of allergy and clinical immunology. Cited 35 times. https://doi.org/10.1016/j.jaci.2011.03.050

The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos

Marc Via, A. D. Giacomo, H. Corvol, et al.. (2010). Clinical & Experimental Allergy. Cited 34 times. https://doi.org/10.1111/j.1365-2222.2009.03438.x

Inhaled corticosteroids and augmented bronchodilator responsiveness in Latino and African American asthmatic patients.

M. Naqvi, H. Tcheurekdjian, Julie A. DeBoard, et al.. (2008). Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. Cited 32 times. https://doi.org/10.1016/S1081-1206(10)60055-5

Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene

Blanca E. Himes, Blanca E. Himes, Keith S. Sheppard, et al.. (2013). PLoS ONE. Cited 32 times. https://doi.org/10.1371/journal.pone.0056179

Latino populations: a unique opportunity for epidemiological research of asthma.

K. Salari, E. Burchard. (2007). Paediatric and perinatal epidemiology. Cited 29 times. https://doi.org/10.1111/J.1365-3016.2007.00880.X

A genome-wide association study of asthma symptoms in Latin American children

Gustavo N. O. Costa, F. Dudbridge, R. Fiaccone, et al.. (2015). BMC Genetics. Cited 29 times. https://doi.org/10.1186/s12863-015-0296-7

The PTGDR gene is not associated with asthma in 3 ethnically diverse populations.

Y. Tsai, S. Choudhry, Jennifer Kho, et al.. (2006). The Journal of allergy and clinical immunology. Cited 27 times. https://doi.org/10.1016/J.JACI.2006.07.045

Pharmacogenetic response to albuterol among asthmatics.

H. Corvol, E. Burchard. (2008). Pharmacogenomics. Cited 22 times. https://doi.org/10.2217/14622416.9.5.505

Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population

M. Arjomandi, J. Galanter, S. Choudhry, et al.. (2011). Pediatric Allergy, Immunology, and Pulmonology. Cited 21 times. https://doi.org/10.1089/ped.2011.0095

Ethnic Variability in Persistent Asthma After In Utero Tobacco Exposure

Kwei Akuete, Sam S. Oh, S. Thyne, et al.. (2011). Pediatrics. Cited 18 times. https://doi.org/10.1542/peds.2011-0640

ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.

H. Tcheurekdjian, M. Via, Anthony F. De Giacomo, et al.. (2010). The Journal of allergy and clinical immunology. Cited 17 times. https://doi.org/10.1016/j.jaci.2010.06.048

Augmentation of bronchodilator responsiveness by leukotriene modifiers in Puerto Rican and Mexican children.

H. Tcheurekdjian, S. Thyne, L. Williams, et al.. (2009). Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. Cited 9 times. https://doi.org/10.1016/S1081-1206(10)60126-3

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent.

M. Acosta-Herrera, M. Pino-Yanes, Shwu-Fan Ma, et al.. (2015). The Journal of allergy and clinical immunology. Cited 8 times. https://doi.org/10.1016/j.jaci.2015.04.025

[Immunoscintigraphy with radionuclide-labeled monoclonal antibodies for tumor diagnosis and in benign diseases].

R. Baum, A. Hertel, G. Hör. (1989). Immunitat und Infektion.
NCPI Dataset Catalog
Feedback & Support
v0.9.0-d9e5747