<p>The overall goal for this study was to determine the genetic factors associated with extreme phenotypes of subclinical atherosclerosis (protective and deleterious). Study participants were selected from the Northern Manhattan Study (NOMAS), a population based cohort study investigating stroke and stroke risk factors in Northern Manhattan. Cases and controls were individuals at the extreme ends of the distribution for carotid intima-media thickness and carotid plaque, with cases defined as individuals with subclinical atherosclerosis that could not be explained by traditional vascular risk factors (USAth) and controls defined as individuals with unexplained protection against atherosclerosis (UPAth).</p>

Novel Genetic Factors for Subclinical Carotid Atherosclerosis

Carotid plaque, a subclinical precursor of vascular events

Homocysteine and the Risk of Ischemic Stroke in a Triethnic Cohort: The Northern Manhattan Study

Traditional Cardiovascular Risk Factors Explain the Minority of the Variability in Carotid Plaque

Traditional Risk Factors Are Not Major Contributors to the Variance in Carotid Intima-Media Thickness