NHLBI TOPMed: Outcome Modifying Genes in Sickle Cell Disease (OMG)

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Anthropometry (2)

cm_height - Height (phv00421704.v1.p1)
kg_weight - Weight (phv00421703.v1.p1)

Biomarkers (18)

bp_diastol - Diastolic blood pressure (phv00421706.v1.p1)
bp_systol - Systolic blood pressure (phv00421705.v1.p1)
c_hct_ave - Current hematocrit - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421711.v1.p1)
c_hgb_ave - Current hemoglobin level - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421710.v1.p1)
c_mch_ave - Current mean corpuscular hemoglobin - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421716.v1.p1)
c_mchc_ave - Current mean corpuscular hemoglobin concentration - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421717.v1.p1)
c_mcv_ave - Current mean corpuscular volume - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421715.v1.p1)
c_platelets_ave - Current platelet count - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421714.v1.p1)
c_rbc_ave - Current red blood cell count - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421712.v1.p1)
c_wbc_ave - Current white blood cell count - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421713.v1.p1)
p_hct_ave - Pre-hydroxyurea hematocrit (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421720.v1.p1)
p_hgb_ave - Pre-hydroxyurea hemoglobin level (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421719.v1.p1)
p_mch_ave - Pre-hydroxyurea mean corpuscular hemoglobin (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421725.v1.p1)
p_mchc_ave - Pre-hydroxyurea mean corpuscular hemoglobin concentration (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421726.v1.p1)
p_mcv_ave - Pre-hydroxyurea mean corpuscular volume (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421724.v1.p1)
p_platelets_ave - Pre-hydroxyurea platelet count (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421723.v1.p1)
p_rbc_ave - Pre-hydroxyurea red blood cell count (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421721.v1.p1)
p_wbc_ave - Pre-hydroxyurea white blood cell count (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421722.v1.p1)

Demographics (2)

age - Age (phv00421709.v1.p1)
sex - Sex (phv00421702.v1.p1)

Medications (23)

antibiotics - Chronic use of antibiotics (phv00493793.v1.p1)
antidepressants - Chronic use of anti-depressants (phv00493803.v1.p1)
bld_prs_meds - Chronic use of blood pressure medications (phv00493796.v1.p1)
bronchodilators - Chronic use of bronchodilators (phv00493804.v1.p1)
demerol - Daily Demerol use at home for pain (phv00493790.v1.p1)
desferol - Chronic use of Desferol (phv00493795.v1.p1)
dilaudid - Daily Dilaudid use at home for pain (phv00493789.v1.p1)
diuretics - Chronic use of diuretics (phv00493797.v1.p1)
erythropoietin - Chronic use of Erythropoietin (phv00493792.v1.p1)
fent_patch - Daily Fentanyl patch at home for pain (phv00493785.v1.p1)
heart_meds - Chronic use of heart medications (phv00493799.v1.p1)
hormones - Chronic use of hormones (phv00493801.v1.p1)
insulin - Chronic use of insulin (phv00493798.v1.p1)
methadone - Daily Methadone use at home for pain (phv00493784.v1.p1)
migraine_meds - Chronic use of migraine medications (phv00493800.v1.p1)
morphine - Daily Morphine use at home for pain (phv00493791.v1.p1)
ms_contin - Daily MS Contin use at home for pain (phv00493782.v1.p1)
oxycodone - Daily Oxycodone use at home for pain (phv00493788.v1.p1)
oxycontin - Daily Oxycontin use at home for pain (phv00493783.v1.p1)
percocet - Daily Percocet at home for pain (phv00493787.v1.p1)
tylenol - Daily Tylenol with codeine at home for pain (phv00493786.v1.p1)
ulcer_meds - Chronic use of ulcer medications (phv00493802.v1.p1)
vitamins - Chronic use of vitamins (including folate) (phv00493794.v1.p1)

Other (20)

ANALYTE_TYPE - Analyte Type (phv00421730.v1.p1)
BODY_SITE - Body site where sample was collected (phv00421729.v1.p1)
c_retic_ave - Current reticulocyte percentage - average of up to 3 baseline values; patient had not been transfused for 3 months prior (phv00421718.v1.p1)
CONSENT - Consent group as determined by DAC (phv00421698.v1.p1)
Funding_Source - Project funding source (phv00421734.v1.p1)
hb_diagnosis - Hemoglobin diagnosis (phv00421707.v1.p1)
HISTOLOGICAL_TYPE - Cell or tissue type or subtype of sample (phv00421732.v1.p1)
hu - Current Hydroxyurea use (phv00421708.v1.p1)
IS_TUMOR - Tumor status (phv00421731.v1.p1)
p_retic_ave - Pre-hydroxyurea reticulocyte percentage (for those currently on HU) - average of up to 3 baseline values; patient had not been transfused for 3 months (phv00421727.v1.p1)
SAMPLE_ID - Sample ID (phv00421728.v1.p1)
SAMPLE_ID - Sample ID (phv00421700.v1.p1)
SEQUENCING_CENTER - Name of the center which conducted sequencing (phv00421733.v1.p1)
Study_Name - TOPMed-assigned short study name (1:1 with TOPMed phs number) (phv00421737.v1.p1)
SUBJECT_ID - De-identified subject ID (phv00421701.v1.p1)
SUBJECT_ID - De-identified subject ID (phv00493781.v1.p1)
SUBJECT_ID - Subject ID (phv00421697.v1.p1)
SUBJECT_ID - Subject ID (phv00421699.v1.p1)
TOPMed_Phase - TOPMed Phase (phv00421735.v1.p1)
TOPMed_Project - TOPMed Project that funded sequencing (phv00421736.v1.p1)