<p>Genetic risks underlying respiratory diseases (e.g. COPD and asthma) are carefully studied by large genome-wide association studies (GWAS), where many loci were identified. In the post-GWAS era, the main challenge is to find the causal genes and pathways in GWAS-nominated chromosomal regions and to characterize etiology mechanism. The Lung eQTL Consortium is an international effort to systematically capture the genetic architecture of gene expression regulation in human lung. By studying lung specimens from 1,103 individuals of mostly European ancestry, we report a large number of genetic variants affecting gene expression in the lung, or lung expression quantitative trait loci (eQTL). These lung eQTLs will serve as an important resource to aid in the understanding of the molecular underpinnings of lung biology and its disruption in disease.</p>

Human Lung Tissue eQTL Study

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD

Molecular mechanisms underlying variations in lung function: a systems genetics analysis.

Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations

Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction