<p>Neoantigen-specific T cell responses were characterized in 4 patients with non-small cell lung cancer. Candidate neoantigens were identified by sequencing tumor and normal DNA from each patient, and ranking single nucleotide variants by expression. Multiple T cell responses were isolated, and in two patients with lung adenocarcinoma, CD4+ T cell responses to recurrent oncogenic mutations in KRAS and Her2 were identified.</p>

Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer, including    KRAS and Her2

1 selected publication including "Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients,..." (80 citations)

Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer, including KRAS and Her2

Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations