<p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems and varies in severity across different populations. To examine the clinical heterogeneity of SLE, we sought to identify different lupus subtypes within our multi-ethnic cohort using a clustering approach. Additionally, with genome-wide methylation and genotype data generated for our cohort, we applied integrative methods to investigate genetic and epigenetic risk factors. This integrative and computational approach revealed molecular differences associated with phenotypic clusters. </p>

Systemic Lupus Erythematosus Subtypes in a Multi-Ethnic Cohort

Lupus Erythematosus, Systemic study with Methylation (CpG), SNP Genotypes (Array) data on dbGaP (333 participants)