<p>These clinical specimens represent solid tumors and matched blood controls that were collected as part of patients' routine care at Memorial Sloan Kettering Cancer Center. They were sequenced on the targeted platform MSK-IMPACT. Here, we performed germline variant calling on the normal blood specimens and assessed their zygosity in the concomitant tumor specimens for comprehensive exploration of the landscape of pathogenic germline variants in patients with advanced cancer.</p>

Germline Variants of Clinical Cancer Specimens

1 selected publication including "Tumour lineage shapes BRCA-mediated phenotypes" (338 citations)